Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 63 - 63
Опубликована: Янв. 5, 2025
Self-emulsifying
drug
delivery
systems
(SEDDS)
represent
an
innovative
approach
to
improving
the
solubility
and
bioavailability
of
poorly
water-soluble
drugs,
addressing
significant
challenges
associated
with
oral
delivery.
This
review
highlights
advancements
applications
SEDDS,
including
their
transition
from
liquid
solid
forms,
while
formulation
strategies,
characterization
techniques,
future
prospects
in
pharmaceutical
sciences.
The
systematically
analyzes
existing
studies
on
focusing
classification
into
forms
preparation
methods,
spray
drying,
hot-melt
extrusion,
adsorption
onto
carriers.
Characterization
techniques
such
as
droplet
size
analysis,
dissolution
studies,
solid-state
evaluations
are
detailed.
Additionally,
emerging
trends,
3D
printing,
hybrid
systems,
supersaturable
SEDDS
(Su-SEDDS),
explored.
Liquid
(L-SEDDS)
enhance
absorption
by
forming
emulsions
upon
contact
gastrointestinal
fluids.
However,
they
suffer
stability
leakage
issues.
Transitioning
(S-SEDDS)
has
resolved
these
limitations,
offering
enhanced
stability,
scalability,
patient
compliance.
Innovations
personalized
3D-printed
biologics
delivery,
targeted
demonstrate
potential
for
diverse
therapeutic
applications.
Computational
modeling
silico
approaches
further
accelerate
optimization.
have
revolutionized
enabling
precise,
patient-centric
therapies.
While
scalability
excipient
toxicity
persist,
technologies
multidisciplinary
collaborations
paving
way
next-generation
SEDDS.
Their
adaptability
medicine
solidify
role
a
cornerstone
modern
development.
Язык: Английский
Design and development of Dasatinib nanoemulsions for ocular delivery: In vitro characterization, biocompatibility, and Ex vivo ocular irritation study
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125504 - 125504
Опубликована: Март 1, 2025
Язык: Английский
Nanoemulsion for enhanced absorption and anti-tumor activity of dasatinib
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106870 - 106870
Опубликована: Март 1, 2025
Язык: Английский
Green One-Pot Synthesis of Thiazole Scaffolds Catalyzed by Reusable NiFe2O4 Nanoparticles: In Silico Binding Affinity and In Vitro Anticancer Activity Studies
Satish Gudala,
Archi Sharma,
Aruna Lankada
и другие.
ACS Omega,
Год журнала:
2024,
Номер
9(36), С. 38262 - 38271
Опубликована: Авг. 29, 2024
A
facile,
green,
one-pot
multicomponent
synthesis
strategy
was
employed
to
fabricate
novel
thiazole
scaffolds
incorporating
phthalazine,
pyridazine,
and
pyrido-pyridazine
derivatives
(4a–4o).
This
synthetic
route
entailed
the
reaction
of
an
α-halo
carbonyl
compound
(1)
with
thiosemicarbazide
(2)
various
anhydrides
(3a–3o),
utilizing
NiFe2O4
nanoparticles
as
a
reusable
catalyst
in
ethanol:water
(1:1)
solvent
system.
The
cytotoxicity
synthesized
compounds
meticulously
assessed
against
three
cancer
cell
lines,
A375,
HeLa,
MCF-7,
employing
IC50
values
(μM)
benchmark,
compared
reference
drug
erlotinib.
Compound
4n
displayed
remarkable
efficacy
A375
(0.87
±
0.31
μM),
HeLa
(1.38
1.24
MCF-7
(1.13
0.96
μM)
significantly
surpassing
erlotinib's
values.
Additionally,
4k,
4l,
4m,
4o
demonstrated
notable
across
all
tested
indicating
their
potential
effective
anticancer
agents.
In
silico
docking
studies
Hsp82
Hsp90
proteins
indicated
that
ligands
4c,
4j,
4o,
4l
had
superior
binding
affinities
ADME
analysis
showed
4n,
favorable
pharmacokinetic
profiles,
including
nontoxicity,
high
human
intestinal
absorption,
low
CYP
inhibitory
promiscuity.
Structure–activity
relationship
revealed
cyano
benzylidene
substitutions
enhanced
activity.
Overall,
compounds,
particularly
efficacy,
interactions,
promising
making
them
strong
candidates
for
further
development
Язык: Английский