Advances and Challenges in Modeling Autosomal Dominant Polycystic Kidney Disease: A Focus on Kidney Organoids

Biomedicines, Год журнала: 2025, Номер 13(2), С. 523 - 523

Опубликована: Фев. 19, 2025

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent hereditary disorder characterized by distinct phenotypic variability that has posed challenges for advancing in-depth research. Recent advancements in organoid construction technologies have enabled researchers to simulate development and create simplified vitro experimental environments, allowing more direct observation of how genetic mutations drive pathological phenotypes disrupt physiological functions. Emerging technologies, such as microfluidic bioreactor culture systems single-cell transcriptomics, further supported the complex ADPKD organoids, offering robust models exploring mechanisms facilitating drug discovery. Nevertheless, significant remain constructing accurate models. This review will summarize recent advances construction, focusing on limitations current techniques critical issues need be addressed future breakthroughs. New Noteworthy: presents particularly iPSC-derived models, new insights into It focuses limited vascularization maturity, proposing potential solutions through emerging technologies. The ongoing optimization expected enhance understanding breakthroughs targeted therapy development.

Язык: Английский

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Do Overweight Status and Obesity Affect Progression to ESKD in Autosomal Dominant Polycystic Kidney Disease?

Clinical Journal of the American Society of Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Division of Nephrology, University Health Network, Toronto, Ontario, Canada Correspondence: Dr. York Pei, email: [email protected] See related article, "Overweight Status, Obesity, and Progression to ESKD in Patients with Autosomal Dominant Polycystic Kidney Disease," on pages 520–528.

Язык: Английский

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Genetic and protein structure prediction analyses identify a rare pathogenic PKD1 variant causing autosomal dominant polycystic kidney disease

CEN Case Reports, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

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Diagnosis of Autosomal Dominant Polycystic Kidney Disease in a 66-Year-Old Patient With a Genotype-Phenotype Mismatch

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Язык: Английский

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Spontaneous Forearm Hemorrhage in a Patient With Polycystic Kidney Disease: A Case Report

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Язык: Английский

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Genetic categorization of congenital genitourinary abnormalities from an embryological perspective

Gene Reports, Год журнала: 2025, Номер unknown, С. 102229 - 102229

Опубликована: Апрель 1, 2025

Язык: Английский

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Metabolic reprogramming in polycystic kidney disease and other renal ciliopathies

EMBO Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

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