Exploring the complex interplay: gut microbiome, stress, and leptospirosis

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Фев. 27, 2024

Leptospirosis, a re-emerging zoonotic disease, remains significant global health concern, especially amid floods and disasters such as the Kakhovka Dam destruction. As is known, stress that occurs in conditions of military conflicts among civilian personnel significantly affects susceptibility to infectious diseases possibly even influences their course. This review aims explore how gut microbiome mediators (such catecholamines corticosteroids) might impact leptospirosis disease The opens new horizons for research by elucidating connections between microbiome, stress, leptospirosis.

Язык: Английский

---

Characterizing of dropouts in the mental health of refugees and asylum seekers (MEHIRA) study examining the effects of a stepped and collaborative care model – a multicentered rater-blinded randomized controlled trial

Psychological Medicine, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Янв. 8, 2025

Abstract Background Dropout from healthcare interventions can negatively affect patients and providers through impaired trust in the system ineffective use of resources. Research on this topic is still largely missing refugees asylum seekers. The current study aimed to characterize predictors for dropout Mental Health Refugees Asylum Seekers (MEHIRA) study, one largest multicentered controlled trials investigating effectiveness cost-effectiveness a nationwide stepped collaborative care model. Methods Predictors were multiply imputed selected descriptive modelling using backward elimination. final variable set was entered into logistic regression. Results overall rate 41,7%. higher participants group therapy ( p = 0.001; OR 10.7), with larger satisfaction social relationships 0.017; 1.87), difficulties maintaining personal 0.005; 4.27), depressive symptoms 0.029; 1.05). Participants living refugee accommodation 0.040; 0.45), change status 0.008; 0.67) conduct 0.020; 0.24) emotional problems 0.013; 0.31) significantly less likely drop out treatment. Conclusion Overall, outcomes suggest that assessing relationships, status, conditions should be considered as topics psychological treatment increase adherence future research studies (including type).

Язык: Английский

---

The phenomenon of neurological components prevalence in influencing the quality of life of patients with the atopic dermatitis and allergic contact dermatitis overlap syndrome in modern realities

INTERNATIONAL NEUROLOGICAL JOURNAL, Год журнала: 2025, Номер 20(8), С. 422 - 426

Опубликована: Янв. 16, 2025

Background. Over the last decade, incidence of atopic dermatitis (AD) has increased significantly and reaches from 5 to 20 % in different countries, which is obviously related improvement diagnostic algorithm. According modern data, course AD worsened despite comprehensive treatment methods. To a certain extent, this may be due presence comorbid condition, or overlap syndrome, allergic contact (ACD). The purpose was develop scale for assessing quality life patients with ACD syndrome based on an integrated questionnaire evaluate neurological component disease. Materials Based analysis world publications over past years, authors developed that considers main components + its designation, they proposed Latin abbreviation QLI-OS-AD/ACD-2024 (Quality Life Index Overlap-Syndrome Atopic Dermatitis/Allergic Contact Dermatitis-2024). It results score: 0–7 — does not affect life, 8–14 affects 15–20 worsens life. Results. From selected cohort, 16 (29.1 %) patients, according survey, received total score 1 7 points characterized impact disease their as significant, 32 (58.2 assessed substantial, having 8 14 points. (12.7 who 15 found greatest influence panel exerted by sleep cognitive functions: negative noted 42 (76.4 participants, 31 (56.4 sometimes 11 (20.0 always; deterioration memory attention recorded 43 (78.2 cases, 35 (63.6 (14.5 always. Conclusions. makes it possible assess degree dermatological detection prevalence phenomenon allows referred neurologist timely manner adequate approach syndrome.

Язык: Английский

---

Українська адаптація шкали для оцінки генералізованого тривожного розладу GAD-7: досвід діагностики в умовах воєнного стану

Insight the psychological dimensions of society, Год журнала: 2024, Номер 11, С. 77 - 103

Опубликована: Май 1, 2024

Мета дослідження – розробити україномовну адаптацію методики оцінки генералізованого тривожного розладу GAD-7 та перевірити її психометричні властивості. Методи. Прямий і зворотній переклад здійснювався незалежно декількома фахівцями, що мають фахову підготовку з англійської філології психології, після чого підлягав експертній перевірці узгодженості. Збір даних відбувався онлайн проходив у два етапи (грудень 2023 р., січень 2024 р.). Вибірку склали цивільні українці віком 17–75 років, які проживали в різних областях країни або перебували вимушеній міграції за кордоном (786 315 осіб відповідно), серед них переважали жінки вищою освітою. Результати переконують високій психометричній компетентності адаптованого інструменту. Підтверджено відмінні показники внутрішньої узгодженості й дискримінативності пунктів, показано ретестову надійність критеріальну валідність шкали (кореляції показниками опитувальників “Психічне здоров’я дорослих” Шкали позитивного ментального здоров’я). Факторна структура відповідає оригінальній одновимірній моделі. Показник достатньо точно прогнозує необхідність звернення психологічною допомогою, має міцні прямі кореляції діагностичними змінними, вимірюють тривожність депресію, негативно корелює оцінками психологічного здоров’я. Водночас емпіричні вибірці розподілені анормально: більше 40.0% респондентів отримали оцінку 10 балів, вияву патологічної симптоматики. Такі не рекомендовано однозначно інтерпретувати як свідчення розладу, оскільки вони можуть відображати закономірний вплив тривалої воєнної агресії на психоемоційний стан українців (неадаптивна реакція хронічний стрес, психологічне травмування тощо). Обидва статуси свідчать про порушення психічного потребують відповідних втручань, проте шляхи засоби цієї допомоги різняться. Середній показник тривоги жінок значимо перевищує такий чоловіків (9.70 6.93 природним особливостям цього стану. Висновки. Адаптована україномовна версія є ефективним інструментом для скринінгу симптомів психологічній практиці наукових дослідженнях, тому числі екстремальних умовах існування. У ситуації воєнного стану слід відрізняти клінічні розлади, пов’язані тривогою, від ситуативно-обумовленої реакції об’єктивну небезпеку, потребує додаткових досліджень.

---

Associations between mental health symptoms, trauma, quality of life and coping in adults living in Ukraine: A cross-sectional study a year after the 2022 Russian invasion

Psychiatry Research, Год журнала: 2024, Номер 339, С. 116056 - 116056

Опубликована: Июнь 26, 2024

We aimed to assess the mental health of adults living in Ukraine one year after onset Russo-Ukrainian war, along with quality life and coping strategies. Quota sampling was used collect online survey data from 2364 aged 18-79 years April 5, 2023 May 15, 2023. Among Ukraine, 14.4 % had probable post-traumatic stress disorder (PTSD), another 8.9 complex PTSD (CPTSD), 44.2 depressive disorder, 23.1 anxiety 38.6 showed significant loneliness. In adjusted models, number trauma events experienced during war a dose-response association PTSD/CPTSD associated disorder. Quality domains, particularly physical life, were negatively PTSD/CPTSD, events. Maladaptive positively All domains using adaptive Mental disorders are highly prevalent into war. Policy services can promote strategies improve for increased resilience

Язык: Английский

---

Well-being of mental health workers during the Russian-Ukrainian War

Mental Health Global Challenges Journal, Год журнала: 2024, Номер 7(1), С. 41 - 49

Опубликована: Март 24, 2024

Introduction: While the detrimental impact of Russian-Ukrainian War on mental health Ukrainian population has been well-documented, less attention given to workers (MHWs) providing support services amid war. Purpose: To examine levels domain-specific well-being in MHWs; identify and quantify relative importance factors associated with well-being; interactions risk protective relation each domain. Methodology: A convenience sample 178 MHWs completed a survey that assessed their well-being, sociodemographic, war-related, health, psychosocial characteristics. Results: Lower difficulties such as anxiety posttraumatic stress symptoms, higher optimism, gratitude, presence search for meaning were well-being. high more likely report even difficulties. Conclusions: Results this study provide insight into correlates multiple domains among ongoing war. They further suggest interventions mitigate bolster may help promote

Язык: Английский

---

Communicable diseases in Ukraine during the period of 2018–2023: Impact of the COVID-19 pandemic and war

Travel Medicine and Infectious Disease, Год журнала: 2024, Номер 60, С. 102733 - 102733

Опубликована: Июнь 26, 2024

By examining 2018-2023 data, this study explored the intricate impact of Russian invasion, ongoing COVID-19 pandemic, and environmental disruptions on communicable diseases in Ukraine. This conflict exacerbates challenges disease surveillance healthcare, compounding stress among population.

Язык: Английский

---

Prevalence of post-traumatic stress disorder and depressive symptoms among civilians residing in armed conflict-affected regions: a systematic review and meta-analysis

General Psychiatry, Год журнала: 2024, Номер 37(3), С. e101438 - e101438

Опубликована: Июнь 1, 2024

Background Globally, populations afflicted by armed conflict are known to have high rates of mental health disorders. Aims This meta-analysis aims estimate the prevalence post-traumatic stress disorder (PTSD) and depressive symptoms among civilians residing in conflict-affected regions. Methods was conducted accordance with Preferred Reporting Items for Systematic Reviews Meta-Analyses. A literature search employing MEDLINE(R), Embase Classic+Embase, APA PsycINFO, Ovid Healthstar, Journal@Ovid Full Text, Cochrane, PTSDpubs CINAHL from inception until 19 March 2024 identify relevant studies. Quality assessment performed using Joanna Briggs Institute Critical Appraisal Checklist Prevalence Studies, a Comprehensive Meta-Analysis used conduct statistical analysis. Results The yielded 38 595 articles, which 57 were considered eligible inclusion. included studies comprised data 64 596 participants. We estimated 23.70% (95% CI 19.50% 28.40%) PTSD 25.60% 20.70% 31.10%) features war-afflicted civilians. subgroup analysis based on time since war country’s economic status revealed highest both present during years low/middle-income countries. Conclusions results this study provide conclusive evidence detrimental impacts outcomes. Hence, it is crucial emphasise significance physical aftermath take appropriate humanistic measures overcome challenges management psychiatric illnesses. PROSPERO registration number CRD42023416096.

Язык: Английский

---

Resilience of Primary Health Care in Ukraine: Challenges of the Pandemic and War

Health Systems & Reform, Год журнала: 2024, Номер 10(1)

Опубликована: Июнь 14, 2024

This commentary examines the resilience of primary health care in Ukraine amidst ongoing war, drawing a few reflections relevant for other fragile and conflict-affected situations. Using personal observations various published unpublished reports, this article outlines five on strengths, challenges, necessary adaptations Primary Health Care (PHC) Ukraine. It underscores concerted efforts government to maintain public financing PHC, thereby averting system collapse. The research also highlights role strategic during COVID-19 pandemic fostering including widespread use digital communication skills training. emphasizes managerial financial autonomy facilitating quick efficient organizational response crisis. recognizes emerging better access PHC services among internally displaced persons, shifting patient profiles service needs, challenges related reliance local financing. Finally, authors advocate coordinated approach humanitarian response, recovery efforts, development programs ensure sustainability effectiveness

Язык: Английский

---

Online control of educational results of the unit “Electricity” in the conditions of blended learning

Journal of Physics Conference Series, Год журнала: 2024, Номер 2871(1), С. 012013 - 012013

Опубликована: Окт. 1, 2024

Abstract The article describes the technology of online control educational results unit “Electricity” in conditions blended learning. It was determined that during stages studying “Electricity”, reverse communication is an urgent issue when receiving information a distance format, and designed to support organization modern training session. Three topics have been singled out unit, context which it appropriate develop measures. Topic I “Electric Field Vacuum” focuses on study electric field strength, potential, relationship between strength dipole, circulation flow field. II Substance” involves dielectrics conductors III Current” includes general laws current, circuit, current circuit with capacitor, work power. There are outlined different types tests: graphical, calculation, animated, audio form means unit. developed provides for organic combination presentation materials research methodology involved analysis synthesis scientific, pedagogical, methodological sources empirical methods, as well obtained results. Before introduction after completion experimental work, conducted, included quality knowledge specified topic. before experiment were tested using Pearson statistical test χ 2 .

Язык: Английский

---