Serum Spike Protein Persistence Post COVID Is Not Associated with ME/CFS

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1086 - 1086

Опубликована: Фев. 8, 2025

Background/Objectives: According to the World Health Organization (WHO) and Centers for Disease Control Prevention (CDC), an estimated 3–6% of people suffer from post-COVID condition or syndrome (PCS). A subset meets diagnostic criteria myalgic encephalomyelitis/chronic fatigue (ME/CFS). Studies have reported that SARS-CoV-2 proteins RNA can persist after acute infection in serum tissues, but their role PCS is unclear. Methods: Here, spike protein was analyzed 121 patients with predominant exertional intolerance, whom 72 met ME/CFS, 37 recovered healthy controls, 32 pre-pandemic controls. Results: Spike detected 11% 2% patients, 14% ME/CFS between 4 31 months infection, not samples. The occurrence concentration did correlate vaccination timepoints. In presence associated severity symptoms functional disability. 5 out 22 who under-went immunoglobulin depletion, levels were reduced undetectable treatment, indicating binding immunoglobulins. Conclusions: summary, this study identified a found no association ME/CFS.

Язык: Английский

A Machine-Learning Approach to Finding Gene Target Treatment Options for Long COVID

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Abstract Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), encompasses a range symptoms persisting for weeks or months after the acute phase COVID-19. These symptoms, affecting multiple organ systems, significantly impact quality life. This study employs machine-learning approach to identify gene targets treating COVID. Using datasets GSE275334, GSE270045, and GSE157103, Recursive Ensemble Feature Selection (REFS) was applied key genes associated with The highlights therapeutic potential targeting such PPP2CB, SOCS3, ARG1, IL6R, ECHS1. Clinical trials pharmacological interventions, including dual antiplatelet therapy anticoagulants, are explored their efficacy in managing COVID-19-related complications. findings suggest that machine learning can effectively biomarkers targets, offering promising avenue personalized treatment strategies COVID patients.

Язык: Английский

Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients

Brain Behavior and Immunity, Год журнала: 2024, Номер 124, С. 97 - 114

Опубликована: Ноя. 29, 2024

Язык: Английский