Phylodynamic analysis revealed that human mobility and vaccination were correlated to the local spread of SARS-CoV-2 in Republic of Korea

Emerging Microbes & Infections, Год журнала: 2023, Номер 12(2)

Опубликована: Июнь 24, 2023

Following the global emergence of SARS-CoV-2 Alpha variant concern (VOC) in 2020, Delta triggered another wave 2021. The AY.69 lineage, a VOC, was particularly prevalent Republic Korea (South Korea) from May 2021 to January 2022, despite synchronized implementation vaccination programmes and non-pharmaceutical interventions (NPIs) such as social distancing. In this study, we used phylogeographic analysis combined with generalized linear model (GLM) examine impact human movement on viral transmission. Our findings indicated that transmission primarily originated South Korea's metropolitan areas, positive correlation observed between total mobility (tracked by GPS mobile phones estimated through credit card consumption) spread. phylodynamic further revealed non-vaccinated individuals were primary transmitters virus during study period, even though had commenced three months prior outbreak. emphasizes need focus controlling regions among unvaccinated populations. Furthermore, data dissemination could contribute development more accurate predictive models for local spread pandemics.

Язык: Английский

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Clinical features of COVID-19 among patients with end-stage renal disease on hemodialysis in the context of high vaccination coverage during the omicron surge period: a retrospective cohort study

BMC Nephrology, Год журнала: 2023, Номер 24(1)

Опубликована: Июнь 27, 2023

Abstract Background We determined the clinical presentation and outcomes of Omicron variant severe acute respiratory syndrome coronavirus 2 infection in hemodialysis patients identified risk factors for disease (COVID-19) mortality context high vaccination coverage. Methods This was a retrospective cohort study involving who were vaccinated against COVID-19 during March–September 2022, when predominant, rate high. The proportion people with or evaluated using univariate logistic regression. Results Eighty-three (78.3%) had asymptomatic/mild symptoms, 10 (9.4%) moderate 13 (12.3%) symptoms. Six (5.7%) required intensive care admission, two (1.9%) mechanical ventilation, one (0.9%) kept on high-flow nasal cannula. Of five (4.7%) cases, directly attributed to four pre-existing comorbidities. Risk both advanced age; number comorbidities; cardiovascular diseases; increased levels aspartate transaminase, lactate dehydrogenase, blood urea nitrogen/creatinine ratio, brain natriuretic peptide, red cell distribution; decreased hematocrit albumin. Moreover, vaccinations wasa protective factor mortality. Conclusions Clinical features surge coverage significant low similar those pre-Omicron period

Язык: Английский

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Factors Influencing the Trajectory of COVID-19 Evolution: A Longitudinal Study of 12 Asian Countries

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 21, 2023

Summary Background The effectiveness of different strategies in addressing the COVID-19 pandemic has been assessed, but there is still not enough evidence Asian countries. This study aims to examine factors influencing trajectory evolution Asia, provide insights for optimizing public health policies. Methods In this longitudinal analysis, we combined cases and vaccination percentages from Our Word Data with policy stringency index Oxford Government Response Tracker 12 countries between January 1, 2021, September 30, 2022. An agglomerative hierarchical cluster analysis (HCA) was conducted identify similar trajectories. We also investigated potential impact seasonal variations on virus’ trajectory. relationship level response, coverage, explored using Generalized Additive Models (GAMs). Findings There were noticeable differences among grouped into two clusters based evolutionary similarities. Cluster 1 consisted West (Azerbaijan, Turkey, Bahrain, Israel Lebanon); while 2 included Japan, South Korea, Singapore, Malaysia, Thailand, Cambodia Indonesia. revealed that coverage associated a statistically significant (both P values < 0·0001) ( adj R =0·54). dose-response relationships demonstrated continuous high levels (≥87·6) or (≥ 42·0%) have led decrease infection rates. early increased 0·93 all Furthermore, 0·86 0·90 respectively. All GAMs models significantly improved compared null model <0·0001). Interpretation By strengthening ahead susceptible seasons enhancing personal self-protection measures, transmission population can be reduced even during highly infectious Omicron era. Funding Senior Talent Startup Fund Nanchang University

Язык: Английский

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No Association between SARS-CoV-2 Infection and the Polymorphism of the Toll-like Receptor 7 (TLR7) Gene in Female Population

Diagnostics, Год журнала: 2023, Номер 13(23), С. 3510 - 3510

Опубликована: Ноя. 23, 2023

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded RNA virus. Toll-like receptor 7 (TLR7) recognizes viruses. The TLR7 gene plays critical role in the human innate and adaptive immune response to SARS-CoV-2 infections. Genetic factors probably affect infection susceptibility. In current study, our aim was search for genetic variations associated with COVID-19 patients of Korean population. We designed five gene-specific primers cover coding region gene. Using amplicon sequencing, we screened polymorphisms healthy controls. genotype frequencies, allele Hardy–Weinberg equilibrium (HWE) were examined. identified low-frequency synonymous single nucleotide polymorphism (SNP) (rs864058) There no significant differences or frequencies rs864058 between female controls (p = 1.0). conclusion, low frequency populations not infection.

Язык: Английский

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Long-Term Particulate Matter Exposure and Mortality in Hospitalized Patients with COVID-19 in South Korea

Annals of the American Thoracic Society, Год журнала: 2024, Номер 21(5), С. 759 - 766

Опубликована: Фев. 8, 2024

Rationale: Particulate matter (PM) exposure exacerbates health outcomes by causing lung damage. Objective: To investigate whether prior to PM10 and PM2.5 was associated with clinical among patients coronavirus disease (COVID-19). Methods: Data from the nationwide registration database of National Health Insurance Korea Disease Control Prevention Agency in South were used. The study included adult who admitted monitoring centers or hospitals between October 8, 2020, December 31, 2021, after COVID-19 confirmation. AirKorea database, which compiles air pollutant data 642 stations 162 cities counties across Korea, used extract on PM levels. Average values monthly previous year hospital admission due date confirmation calculated define exposures COVID-19. Results: In total, 322,289 included, 4,633 (1.4%) died during hospitalization. After adjusting for covariates, a 1 mcg/m3 increase 4% (odds ratio [OR]: 1.04, 95% confidence interval [CI]: 1.03–1.05; P<0.001) 6% (OR: 1.06, CI: 1.04–1.07; risk in-hospital mortality, respectively. Additionally, 5% 1.05, P < 0.001) 8% 1.08, 1.06–1.10; risks requiring intensive care unit (ICU) mechanical ventilation, Conclusions: increased mortality need ICU ventilation Korea.

Язык: Английский

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