Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Дек. 18, 2024
ACE2 and TMPRSS2 represent the major gateways for SARS-CoV-2 cell entry. The presence of functional genetic polymorphisms that affect gene expression may risk severe form COVID-19 its fatal outcome.
Язык: Английский
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Янв. 29, 2024
Abstract The constant emergence of SARS-CoV-2 variants continues to impair the efficacy existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved epitope targeted by broad-spectrum antibody BA7535, demonstrates high neutralization potency against not only previous variants, such as Alpha, Beta, Gamma, Delta Omicron BA.1-BA.5, but also more recently emerged subvariants, including BF.7, CH.1.1, XBB.1, XBB.1.5, XBB.1.9.1, EG.5. Structural analysis Spike trimer with BA7535-Fab using cryo-EM indicates that BA7535 recognizes cryptic receptor-binding domain (RBD) epitope, avoiding most mutational hot spots in RBD. Furthermore, structural simulation based on interaction BA7535-Fab/RBD complexes dissects broadly effect latest variants. Therapeutic prophylactic treatment alone or combination BA7208 protected female mice from circulating BA.5 XBB.1 variant infection, suggesting serves potential target for developing potent therapeutic antibodies vaccines.
Язык: Английский
Процитировано
18
The Lancet Infectious Diseases, Год журнала: 2023, Номер 23(10), С. e391 - e392
Опубликована: Сен. 13, 2023
Язык: Английский
Процитировано
33
Vaccines, Год журнала: 2023, Номер 11(9), С. 1502 - 1502
Опубликована: Сен. 19, 2023
The COVID-19 pandemic has been met with an unprecedented response from the scientific community, leading to development, investigation, and authorization of vaccines antivirals, ultimately reducing impact SARS-CoV-2 on global public health. However, is far being eradicated, continues evolve, causes substantial health economic burdens. In this narrative review, we posit essential points its responsible management during transition acute phase pandemic. As discussed, despite Omicron (sub)variant(s) causing clinically milder infections, a negligible pathogen. It requires continued genomic surveillance, particularly if one considers that future (sub)lineages do not necessarily have be milder. Antivirals remain elements in management. former could benefit further development improvements dosing, while seasonal administration latter simplification increase interest tackle vaccine hesitancy. also ensure accessibility pharmaceuticals low-income countries improve understanding their use context long-term goals Regardless location, primary role awareness education must played by healthcare workers, who directly communicate patients serve as models for healthy behaviors.
Язык: Английский
Процитировано
20
The Lancet Regional Health - Europe, Год журнала: 2023, Номер 35, С. 100755 - 100755
Опубликована: Окт. 26, 2023
Since the first emergence of Omicron BA.1 in England November 2021, numerous sub-lineages have evolved. In September 2022, BA.5 dominated. The prevalence BQ.1 increased from October, while CH.1.1 and XBB.1.5 December 2022 January 2023, respectively. Little is known about effectiveness vaccines against hospitalisation with these sub-lineages, nor relative severity, so we here used national-level electronic health records to estimate vaccine variant severity.
Язык: Английский
Процитировано
20
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 5, 2024
Abstract The growing occurrence of novel recombinants, such as XBB.1.16, has emerged and become predominant, raising concerns about the impact genomic recombination on evolution severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigated molecular epidemiological trends Omicron XBB.1.16 epidemic in Bangkok between December 2022 August 2023. Partial spike complete genome sequencing SARS-CoV-2 samples collected from collaborating hospitals were performed. analysis 491 partial sequences identified 15 distinct lineages, with dominating lineages beginning March Phylogenetic revealed at least four suggesting multiple independent introductions into Bangkok. estimated emergence occurred approximately January 2022, an evolutionary rate 0.79 × 10 –3 substitutions per site year. Monitoring epidemiology is vital for early detection new strains or emerging variants, which may guide vaccine design inclusion strains.
Язык: Английский
Процитировано
6
Vaccines, Год журнала: 2024, Номер 12(8), С. 887 - 887
Опубликована: Авг. 5, 2024
Beginning in 2022, following widespread infection and vaccination among the global population, SARS-CoV-2 virus mainly evolved to evade immunity derived from vaccines past infections. This review covers convergent evolution of structural, nonstructural, accessory proteins SARS-CoV-2, with a specific look at common mutations found long-lasting infections that hint potentially reverting an enteric sarbecovirus type.
Язык: Английский
Процитировано
5
Frontiers in Public Health, Год журнала: 2025, Номер 13
Опубликована: Фев. 27, 2025
The emergence of new SARS-CoV-2 variants makes it difficult to forecast potential epidemiological changes. This study investigates Saudi citizens' perceptions COVID-19 during the Omicron wave. We conducted a cross-sectional using an online survey and convenience sample 746 participants. included questions about demographics, anxiety levels, perception Our findings revealed that 27.3% participants believed cases would decrease, while 30.2% increase; remaining 42.5% were uncertain. When asked primary reasons for expecting rise in cases, two most frequently cited causes non-adherence prevention measures (74.7%) high transmissibility virus (66.7%). Conversely, when decrease availability free vaccines (60.3%), government (59.9%), compliance with preventive (57.4%), health awareness programs (44.1%). Multivariate logistic regression analysis indicated (AOR = 1.23, 95% CI: 1.15-1.32) education level 1.58, 1.11-2.25) significant predictors respondents' expectations increases or decreases (p < 0.05). Around 46.2% moderately highly worried reinstatement lockdowns, 36.2% reported moderate levels related COVID-19. Ordinal showed respondents who higher worry lockdowns 1.28 times more likely experience A few hesitant adhere because they had already been vaccinated was not real severe. hesitancy raises public concerns, suggesting some individuals may underestimate risks associated future pandemics. provides valuable insights into how citizens perceived Understanding these can guide development policies, optimize resource allocation, help control transmission viral variants, enhance preparedness
Язык: Английский
Процитировано
0
Archives of Virology, Год журнала: 2025, Номер 170(4)
Опубликована: Март 18, 2025
Язык: Английский
Процитировано
0
The Journal of Infectious Diseases, Год журнала: 2024, Номер 230(5), С. 1197 - 1201
Опубликована: Июль 18, 2024
Abstract Within a multistate viral genomic surveillance program, we evaluated whether proportions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections attributed to the JN.1 variant and XBB-lineage variants (including HV.1 EG.5) differed between inpatient outpatient care settings during periods cocirculation. Both were less likely than EG.5 account for among inpatients versus outpatients (adjusted odds ratio [aOR], 0.60 [95% confidence interval (CI), .43–.84; P = .003] 0.35 [.21–.58; < .001], respectively). may be associated with lower risk illness. The severity disease 2019 have attenuated as predominant circulating SARS-CoV-2 lineages shifted from JN.1.
Язык: Английский
Процитировано
2
International Journal of Infectious Diseases, Год журнала: 2024, Номер 146, С. 107121 - 107121
Опубликована: Май 31, 2024
Язык: Английский
Процитировано
1