Trends in Immunology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Journal of Infection and Public Health, Год журнала: 2025, Номер 18(3), С. 102652 - 102652
Опубликована: Янв. 5, 2025
With the outbreak of COVID-19 in China, a large number patients are at risk long COVID after recovery. The purpose our research is to systematically review existing clinical studies understand current prevalence and related factors China. protocol this systematic was registered on PROSPERO (CRD42024519375). We searched six electronic databases from 1st January 2020-1st March 2024. Literature screening, data extraction, bias assessment were independently carried out by two reviewers. Quality included evaluated AHRQ NOS. meta-analysis performed R software 4.2.3 derive factors. Overall, 50 with 65880 participants included. results showed that (with least one symptom) among approximately % (95 %Confidence Interval (CI) 42-58 %) Although we conducted meta-regression subgroup analysis, heterogeneity study high. But Omicron BA.2 variant had statistically significant effect (P = 0.0004). three most common symptoms fatigue (0.33, 95 %CI 0.28-0.39), cognitive decline (0.30, 0.14-0.46) shortness breath (0.29, 0.15-0.43). Patients severe acute phase (Odds Ratio (OR) 1.57, CI 1.39-1.77), combined 2 comorbidities (OR 1.80, 1.40-2.32), 3 2.13, 1.64-2.77), advanced age 1.02, 1.01-1.04), female 1.58, 1.44-1.73) for prevalence. Current found nearly half may suffering Establishing recovery-support platform regular follow-up would help long-term monitor manage patients, especially those high-risk population.
Язык: Английский
Процитировано
1
The Lancet Infectious Diseases, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
The Lancet Regional Health - Western Pacific, Год журнала: 2025, Номер 55, С. 101474 - 101474
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Microbiome, Год журнала: 2025, Номер 13(1)
Опубликована: Март 11, 2025
The responses of the infant gut microbiota to infection significantly disrupt natural intrahost evolutionary processes microbiome. Here, we collected a 16-month longitudinal cohort microbiomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Then, developed multicriteria approach identify core interaction network driving community dynamics under environmental disturbances, which termed Conserved Variated Interaction Group (CVIgroup). CVIgroup showed significant advantages on pinpointing sparse set associated with as validated both our own and publicly available datasets. Leveraging Oxford Nanopore Technology, found this group facilitates ecosystem's adaptation disruptions enhancing mobility mobile genetic elements, including reinforcement twin-arginine translocation pathway in response increased virulence factors. Furthermore, serves an effective indicator ecosystem health. timescale for microbiota's extends beyond 10 months. Members CVIgroup, such Bacteroides thetaiotaomicron Faecalibacterium, exhibit varying degrees genomic structural variants, contribute guiding toward new stable state rather than returning its original configuration. Collectively, offers snapshot adaptive disturbances. disruption subsequent infants after COVID-19 underscores necessity re-evaluating reference standards context post-pandemic era.
Язык: Английский
Процитировано
0
Infectious Diseases & Immunity, Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Abstract Although the coronavirus disease 2019 (COVID-19) pandemic has ended, enduring health impacts of severe acute respiratory syndrome 2 (SARS-CoV-2) infection continue to garner global attention, as approximately 10% patients develop long COVID (post COVID-19 condition). The epidemiological characteristics and symptoms have been reported, various pathogenic hypotheses proposed. Recent evidence suggests that SARS-CoV-2 nucleic acids or fragments persist in some post-infection these are correlated with symptoms. This review focuses on clinical studies linking persistence symptoms, explores relationship between viral other etiological hypotheses, such immune dysregulation, vascular issues, coagulation dysfunction, microbiome dysbiosis, brainstem/vagus nerve signaling latent virus reactivation. Futhermore, treatment strategies for proposed based current trials antiviral modulation therapies. Understanding role pathogenesis is critical developing targeted therapies improving management this debilitating condition.
Язык: Английский
Процитировано
0
Pathogens, Год журнала: 2024, Номер 13(12), С. 1109 - 1109
Опубликована: Дек. 15, 2024
Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies enhance subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing individuals infected with dengue virus are known to be associated severe disease upon reinfection different serotype. For Severe Acute Respiratory Syndrome Coronavirus type-2 infection, three types ADE have been proposed: (1) Fc receptor-dependent infection cells expressing receptors, such as macrophages by anti-spike antibodies, (2) receptor-independent epithelial and (3) cytokine production anti-nucleocapsid antibodies. This review focuses on the induced examining its potential role COVID-19 during contribution post-acute sequelae COVID-19, i.e., prolonged symptoms lasting at least months after acute phase disease. We also discuss protective effects recently identified that neutralize Omicron variants.
Язык: Английский
Процитировано
2
The Lancet Regional Health - Western Pacific, Год журнала: 2024, Номер 52, С. 101223 - 101223
Опубликована: Окт. 14, 2024
Язык: Английский
Процитировано
1
Trends in Immunology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1