Oncolytic viruses: a potential breakthrough immunotherapy for multiple myeloma patients
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 30, 2024
Oncolytic
virotherapy
represents
an
innovative
and
promising
approach
for
the
treatment
of
cancer,
including
multiple
myeloma
(MM),
a
currently
incurable
plasma
cell
(PC)
neoplasm.
Despite
advances
that
new
therapies,
particularly
immunotherapy,
have
been
made,
relapses
still
occur
in
MM
patients,
highlighting
medical
need
options.
viruses
(OVs)
preferentially
infect
destroy
cancer
cells,
exerting
direct
and/or
indirect
cytopathic
effect,
combined
with
modulation
tumor
microenvironment
leading
to
activation
immune
system.
Both
naturally
occurring
genetically
modified
demonstrated
significant
preclinical
effects
against
cells.
Currently,
OVs
measles
virus
strains,
reovirus,
vesicular
stomatitis
are
employed
clinical
trials
MM.
Nevertheless,
challenges
remain,
efficiency
delivery
tumor,
overcoming
antiviral
responses,
specificity
Different
strategies
being
explored
optimize
OV
therapy,
combining
it
standard
treatments
targeted
therapies
enhance
efficacy.
This
review
will
provide
comprehensive
analysis
mechanism
action
different
OVs,
evidence,
focusing
on
role
oncolytic
as
possible
immunotherapeutic
also
combination
current
therapeutic
armamentarium
underlying
future
directions
context
treatments.
Язык: Английский
Recent and Advanced Trends in Cancer Treatments
National Journal of Community Medicine,
Год журнала:
2024,
Номер
15(12), С. 1090 - 1107
Опубликована: Дек. 1, 2024
Background:
Cancer
treatment
remains
a
critical
area
of
clinical
research,
with
numerous
approaches
developed
depending
on
tumor
type
and
stage.
Recent
advances
in
genetic
immunotherapy,
bioinformatics,
science
have
revolutionized
cancer
diagnosis
treatment.
Emerging
technologies
such
as
gene
delivery,
oncolytic
virotherapy,
suicide
therapy,
CRISPR/Cas9
offer
promising
therapeutic
avenues.
Methods:
This
review
provides
detailed
analysis
the
latest
techniques
Gene
artificial
intelligence,
Nanocarrier
Delivery
Systems,
Immunotherapy,
CAR
T-Cell
Therapy,
Epigenetics,
Vaccines,
Clinical
translation
assessing
their
potential
A
early
studies
focused
integration
nanotechnology,
intelligence
(AI)
therapies
emphasis
targeted
delivery
systems
precision
medicine.
Results:
The
highlights
synergistic
effects
combining
particularly
immune
checkpoint
inhibitors
CAR-T
cell
therapy.
Therapies
demonstrate
significant
targeting,
while
advancements
nanocarrier
enhanced
reduced
side
effects.
AI's
role
improving
personalized
is
also
underscored.
Conclusion:
comprehensive
recent
technological
addresses
gaps
previous
reviews
offers
updated
insights
into
cutting-edge
treatments.
emphasizes
evolving
AI,
providing
clinicians
researchers
most
current
relevant
information
for
optimizing
strategies.
Язык: Английский