Aberrantly Expressed Hsa_circ_0060762 and CSE1L as Potential Peripheral Blood Biomarkers for ALS

Biomedicines, Год журнала: 2023, Номер 11(5), С. 1316 - 1316

Опубликована: Апрель 28, 2023

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive adult-onset neurodegenerative disease that often diagnosed with delay due to initial non-specific symptoms. Therefore, reliable and easy-to-obtain biomarkers are an absolute necessity for earlier more accurate diagnostics. Circular RNAs (circRNAs) have already been proposed as potential several diseases. In this study, we further investigated the usefulness of circRNAs ALS. We first performed microarray analysis on peripheral blood mononuclear cells subset ALS patients controls. Among differently expressed circRNA by analysis, selected only ones host gene harbors highest level conservation genetic constraints. This selection was based hypothesis genes under selective pressure constraints could major role in determining trait or disease. Then linear regression between cases controls using each predictor variable. With False Discovery Rate (FDR) threshold 0.1, six passed filtering one them remained statistically significant after Bonferroni correction: hsa_circ_0060762 its CSE1L. Finally, observed difference expression levels larger sets healthy both CSE1L member importin β family mediates inhibition TDP-43 aggregation; central pathogenicity has binding sites miRNAs addition, receiver operating characteristics curve showed diagnostic hsa_circ_0060762. Hsa_circ_0060762 thus represent novel therapeutic targets

Язык: Английский

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Boosting Mitochondrial Potential: An Imperative Therapeutic Intervention in Amyotrophic Lateral Sclerosis

Current Neuropharmacology, Год журнала: 2022, Номер 21(5), С. 1117 - 1138

Опубликована: Сен. 16, 2022

Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive and terminal neurodegenerative disorder. Mitochondrial dysfunction, imbalance of cellular bioenergetics, electron chain transportation calcium homeostasis are deeply associated with the progression this disease. Impaired mitochondrial functions crucial in rapid neurodegeneration. The mitochondria ALS patients deregulated Ca2+ elevated levels reactive oxygen species (ROS), leading to oxidative stress. Overload ROS production leads glutamatereceptor mediated neurotoxicity. This implies an attractive therapeutic target. Objective: aim review brief latest developments understanding pathogenesis emphasize restorative capacity candidates. Results: In ALS, dysfunction well-known phenomenon. Various therapies targeted towards at decreasing generation, increasing biogenesis, inhibiting apoptotic pathways. Some briefed may be categorized as synthetic, natural compounds, genetic materials, therapies. Conclusion: overarching goals benefit by slowing down disease prolonging overall survival. Despite various approaches, there many hurdles development successful therapy due multifaceted nature progression. Intensive research required precisely elucidate molecular pathways involved dysfunctions that ultimately lead ALS. Because multifactorial combination approach hold key cure treat future.

Язык: Английский

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Diffusion magnetic resonance imaging-based surrogate marker in amyotrophic lateral sclerosis

Exploration of Neuroprotective Therapy, Год журнала: 2023, Номер unknown, С. 186 - 206

Опубликована: Авг. 25, 2023

Amyotrophic lateral sclerosis (ALS) is the most prevalent type of motor neuron disease (MND) and diagnosed with a delay from first appearance symptoms. Surrogate markers that may be used to detect pathological changes before significant neuronal loss occurs allow for early intervention disease-modifying therapy techniques are desperately needed. Using water molecules diffuse within tissue experience displacement on micron scale, diffusion magnetic resonance imaging (MRI) promising technique can infer microstructural characteristics brain, such as integrity complexity, axonal density, order, myelination. Diffusion tensor (DTI) primary MRI evaluate pathogenesis ALS. Neurite orientation dispersion density (NODDI), kurtosis (DKI), free elimination DTI (FWE-DTI) only few approaches have been developed overcome shortcomings technique. This article provides summary these methods their potential surrogate detecting onset ALS at an stage.

Язык: Английский

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Neural Stem Cell Therapies: Promising Treatments for Neurodegenerative Diseases

Neurology Letters, Год журнала: 2023, Номер 2(2), С. 55 - 68

Опубликована: Июль 1, 2023

Neurodegenerative diseases are a group of disorders that progressively damage the nervous system, leading to loss function and disability. Currently, there limited treatment options available for patients suffering from these disorders. However, Neural Stem Cell Therapy is promising new approach has shown great potential in treating various neurodegenerative such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis, ALS, spinocerebellar ataxia, frontotemporal dementia, Creutzfeldt-Jakob Lewy body disease.Through extensive research clinical trials, been reduce inflammation, enhance neuronal regeneration, promote functional recovery neurological In improve cognitive amyloid plaques. Cells have differentiate into dopaminergic neurons motor function. remyelinate damaged axons inflammation.Although more still needed, ongoing progress this field holds significant implications developing with offer hope millions individuals around world who suffer debilitating diseases. As continues evolve, it hoped will ultimately lead better outcomes improved quality life

Язык: Английский

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Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints

Molecular Neurobiology, Год журнала: 2022, Номер 59(10), С. 6373 - 6396

Опубликована: Авг. 6, 2022

Язык: Английский

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