Synthesis, Characterization, and Cytotoxicity Evaluation of Novel Water‐Soluble Cationic Platinum(II) Organometallic Complexes with Phenanthroline and Imidazolic Ligands

Chemistry - A European Journal, Год журнала: 2024, Номер 30(38)

Опубликована: Май 4, 2024

Abstract Platinum‐based chemotherapeutic agents are widely used in the treatment of cancer. However, their effectiveness is limited by severe adverse reactions, drug resistance, and poor water solubility. This study focuses on synthesis characterization new water‐soluble cationic monofunctional platinum(II) complexes starting from [PtCl(η 1 ‐C 2 H 4 OEt)(phen)] ( , phen=1,10‐phenanthroline) precursor, specifically [Pt(NH 3 )(η OEt)(phen)]Cl ), [Pt(1‐hexyl‐1 ‐imidazole)(η ‐benzo[d]imidazole)(η which deviate traditional requirements for antitumor activity. These were evaluated cytotoxic effects comparison to cisplatin, using immortalized cervical adenocarcinoma cells (HeLa), human renal carcinoma (Caki‐1), normal (HK‐2). While complex showed minimal cell lines, demonstrated higher cytotoxicity than cisplatin. Notably, displayed highest both cancer lines. exhibited selectivity tumor (Caki‐1) among tested complexes, compared healthy resulted a significantly that cisplatin . Therefore, shows potential as leading candidate development generation platinum‐based anticancer drugs, utilizing biocompatible imidazole ligands while demonstrating promising properties.

Язык: Английский

---

Ketotifen counteracts cisplatin-induced acute kidney injury in mice via targeting NF-κB/NLRP3/Caspase-1 and Bax/Bcl2/Caspase-3 signaling pathways

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116797 - 116797

Опубликована: Май 21, 2024

Cisplatin (CIS) stands as one of the most effective chemotherapy drugs currently available. Despite its anticancer properties, clinical application CIS is restricted due to nephrotoxicity. Our research aimed specify impact ketotifen fumarate (KET) against nephrotoxicity induced by in mice. Male NMRI mice were treated with KET (0.4, 0.8, and 1.6 mg/kg, ip) for seven days. On fourth day study, a single dose (13 was administered, sacrificed on eighth day. The results indicated that administration attenuated CIS-induced elevation BUN Cr serum, well renal KIM-1 levels. This improvement accompanied significant reduction kidney tissue damage, which supported histopathological examinations. Likewise, decrease ratio GSH GSSG antioxidant enzyme activities (CAT, SOD, GPx), increase lipid peroxidation marker (TBARS) reversed KET-treated ELISA revealed ameliorated levels TNF-α, IL-1β, IL-18. Western blot analysis exhibited suppressed activation transcription factor NF-κB NLRP3 inflammasome CIS-treated Moreover, treatment changes protein expression markers related apoptosis (Bax, Bcl2, Caspase-3, p53). Interestingly, significantly enhanced cytotoxicity HeLa cells. In conclusion, this study provides valuable insights into promising effects mitigating

Язык: Английский

---

Trace elements and metal nanoparticles: mechanistic approaches to mitigating chemotherapy-induced toxicity—a review of literature evidence

BioMetals, Год журнала: 2024, Номер 37(6), С. 1325 - 1378

Опубликована: Сен. 30, 2024

Язык: Английский

---

Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Язык: Английский

---

Appraisals on the anticancer properties of Mentha species using bioassays and docking studies

Industrial Crops and Products, Год журнала: 2023, Номер 203, С. 117128 - 117128

Опубликована: Июль 11, 2023

Язык: Английский

---