BMC Nephrology, Год журнала: 2024, Номер 25(1)
Опубликована: Июль 9, 2024
Some studies have suggested that uric acid has antioxidant properties can prevent bone loss, but the relationship between and mineral density is controversial. The aim of this study was to investigate UA BMD in patients with CKD stage 1-3.
Язык: Английский
Molecular Biomedicine, Год журнала: 2025, Номер 6(1)
Опубликована: Март 22, 2025
Abstract Klotho, initially introduced as an anti-aging protein, is expressed in the brain, pancreas, and most prominently kidney. The two forms of Klotho (membrane-bound soluble form) have diverse pharmacological functions such anti-inflammatory, anti-oxidative, anti-fibrotic, tumour-suppressive etc. membrane-bound form plays a pivotal role maintaining kidney homeostasis by regulating fibroblast growth factor 23 (FGF 23) signalling, vitamin D metabolism phosphate balance. deficiency has been linked with significantly reduced protection against various pathological phenotypes, including diabetic disease (DKD), which major cause chronic leading to end-stage disease. Owing pleiotropic actions klotho, it shown beneficial effects DKD tackling complex pathophysiology reducing inflammation, oxidative stress, well fibrosis. Moreover, protective effect klotho extends beyond other conditions, cardiovascular diseases, alzheimer's disease, cancer, inflammatory bowel liver Therefore, this review summarizes relationship between expression diseases special emphasis on DKD, distinct mechanisms potential exogenous supplementation therapeutic strategy. Future research into could unravel novel treatment avenues for diseases.
Язык: Английский
Процитировано
2
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117050 - 117050
Опубликована: Июль 4, 2024
Cardiovascular disease (CVD) is a leading cause of death in chronic kidney (CKD). Hemodialysis one the main treatments for patients with end-stage disease. Epidemiological data has shown that acute myocardial infarction (AMI) accounts reason CKD under hemodialysis therapy. Immune dysfunction and changes metabolism (including high level inflammatory cytokines, disorder lipid mineral ion homeostasis, accumulation uremic toxins et al.) during can deteriorate stability atherosclerotic plaque promote vascular calcification, which are exactly pathophysiological mechanisms underlying occurrence AMI. Meanwhile, itself also adverse effects on lipoprotein, immune system hemodynamics, contribute to incidence AMI these patients. This review aims summarize further promising methods prevention treatment undergoing hemodialysis, provide an excellent paradigm exploring crosstalk between cardiovascular system.
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2024, Номер 14
Опубликована: Янв. 5, 2024
Background: Chronic kidney disease (CKD) is now globally recognized as a critical public health concern. Vascular calcification (VC) represents significant risk factor for cardiovascular events in individuals with CKD. It the accessible and precise diagnostic biomarkers monitoring progression of CKD concurrent VC are urgently needed. Methods: The adenine diet-induced rat model was utilized to investigate chronic injury, thoracic aorta, dysregulation biochemical indices. Enzyme-linked immune sandwich assays were employed analyze changes calcification-related proteins. 16S rRNA sequencing performed delineate microbiota characteristics gut blood CKD-afflicted rats. Additionally, transcriptome tissue conducted explore relationship between CKD-associated features alterations function. Results: inhibited body weight gain, led pronounced aorta. both these affected rats exhibited significantly lower alpha diversity distinctive beta than those their healthy counterparts. resulted several indices (including elevated levels creatinine, low-density lipoprotein-cholesterol, sodium, phosphorous, total cholesterol, urea decreased albumin, calcium, lactate dehydrogenase, bilirubin). Moreover, it upregulated factors (bone sialoprotein [BSP], Klotho, fibroblast growth [FGF]-23, sclerostin [SOST]) lipopolysaccharide (LPS). Notably, increased Acinetobacter positively associated calcifications addition positive correlation microbiota. enrichment increases (BSP, FGF-23, SOST), LPS, phosphorous. Furthermore, revealed that correlated majority genes negatively downregulated involved mineral absorption pathway. Conclusion: Our findings, first time, underscore dysbiosis symbiotic microbiota, blood, Particularly, emerges potential its accompanying VC.
Язык: Английский
Процитировано
6
Molecular Medicine, Год журнала: 2023, Номер 29(1)
Опубликована: Дек. 8, 2023
Abstract N 6-methyladenosine (m6A) modification is a kind of RNA in which methylation occurs at the sixth position adenosine RNA, can occur various RNAs such as mRNAs, lncRNAs and miRNAs. This one most prominent frequent posttranscriptional modifications within organisms has been shown to function dynamically reversibly variety ways, including splicing, export, attenuation translation initiation efficiency regulate expression. There are three main enzymes associated with m6A modification: writers, readers erasers. Increasing evidence that onset development kidney disease. In this article, we address important physiological pathological roles diseases (uremia, ischemia–reperfusion injury, drug-induced diabetic nephropathy) its molecular mechanisms provide reference for diagnosis clinical management diseases.
Язык: Английский
Процитировано
10
Expert Review of Cardiovascular Therapy, Год журнала: 2023, Номер 21(2), С. 75 - 85
Опубликована: Янв. 30, 2023
Introduction Vascular calcification (VC) which is the pathological mineral deposition in vascular system, predominantly at intimal and medial layer of vessel wall, an important comorbidity patients with chronic kidney disease (CKD) leading to significant morbidity mortality while necessitating appropriate treatment. Our review aims provide in-depth analysis current understanding VC.
Язык: Английский
Процитировано
9
International Journal of Endocrinology, Год журнала: 2024, Номер 2024, С. 1 - 7
Опубликована: Фев. 14, 2024
Objective.
This
study
aims
to
explore
the
relationships
between
serum
indoxyl
sulfate
(IS)
and
Klotho
protein
levels
with
vascular
calcification
in
patients
chronic
kidney
disease
(CKD)
stages
3–5.
Methods.
From
December
2021
January
2023,
a
total
of
108
CKD
3–5
were
enrolled
this
cross-sectional
investigation.
Demographic
information
routine
clinical
biochemistry
test
results
gathered.
Serum
IS
quantified
through
enzyme-linked
immunosorbent
assays.
Furthermore,
multislice
spiral
computed
tomography
was
employed
evaluate
calcification.
The
association
or
abdominal
aorta
assessed
using
univariate
analysis
logistic
regression
analyses.
Results.
With
progression
stages,
creatinine,
phosphorus,
intact
parathyroid
hormone
(iPTH),
IS,
aortic
exhibited
incremental
trends,
while
calcium
showed
diminishing
trend,
statistically
significant
differences
(
).
Significant
observed
age,
blood
calcium,
hormone,
without
id="M2">
Язык: Английский
Процитировано
3
Clinical Kidney Journal, Год журнала: 2024, Номер 17(6)
Опубликована: Июнь 1, 2024
The global derangement of mineral metabolism that accompanies chronic kidney disease (CKD-MBD) is a major driver the accelerated mortality for individuals with disease. Advances in delivery dialysis, composition phosphate binders, and therapies directed towards secondary hyperparathyroidism have failed to improve cardiovascular event profile this population. Many obstacles prevented progress field including incomplete understanding pathophysiology, lack clinical targets early stages disease, remarkably wide diversity manifestations. We describe review novel approach CKD-MBD combining mathematical modelling biologic processes machine learning artificial intelligence techniques as tool generation new hypotheses development innovative therapeutic approaches syndrome. Clinicians need alternative therapy, tools risk assessment, address complications course personalize therapy each individual. complexity suggests incorporating into diagnostic, therapeutic, research armamentarium could accelerate achievement these goals.
Язык: Английский
Процитировано
3
Endocrine Connections, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Metabolic syndrome (MetS) is associated with osteogenic transdifferentiation of vascular smooth muscle cells (VSMC) and accumulation arterial calcifications (AC). Metformin (MET) inhibits this in vitro. Here, we evaluate the vivo efficacy oral MET to reduce AC a model MetS. 20 young male Wistar rats were divided into 2 groups: one received water, other water plus 20% fructose induce After 14 days, for another 4 weeks, (100 mg/kg/day) was added half each group’s drinking source, thus: C (water), F (fructose), M FM (fructose+MET). Serum adipose tissue collected. Aortas dissected histomorphometric immunohistochemical analysis; ex calcification studies; isolate VSMC measure their alkaline phosphatase activity (ALP), collagen production, extracellular mineralization, gene expression RUNX2 RAGE (receptor AGEs), elastic fiber production. group showed parameters compatible Aortic tunica media from decreased elastic-to-muscular ratio, increased content levels AGEs carboxymethyl-lysine. arches presented tendency higher calcification. ALP, secretion, mineralization RAGE; All these effects reverted by co-treatment (FM group). In vitro, AGEs-BSA upregulated control VSMC, prevented an AMPK-dependent manner. Thus, experimental MetS induces upregulation aortic that curbed treatment MET.
Язык: Английский
Процитировано
0
BMC Nephrology, Год журнала: 2025, Номер 26(1)
Опубликована: Янв. 11, 2025
Calcification of the radial artery is one main causes anastomotic stenosis in autogenous arteriovenous fistulas uremic patients. However, pathogenesis calcification still unknown. This study attempted to screen and validate risk factors for vascular patients with uremia. Serum blood were collected tissue samples from obtained 60 uremia or without hemodialysis. General biochemical indicators calcification-related molecules detected via ELISA correlation analysis. In addition, pathological changes evaluated by HE immunohistochemical staining. There differences total calcium, calcium-phosphorus products, allograft inflammatory factor 1 (AIF-1), intact parathyroid hormone (iPTH), vitamin D (VD), fibroblast growth 23 (FGF23) soluble klotho (sKlotho) Furthermore, these are related artery. The expression AIF-1, PTHR1, VDR, FGF23 sKlotho was also increased calcified levels PTH, serum associated further aggravated abnormalities calcium phosphorus maintenance hemodialysis
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2025, Номер 13(1), С. 235 - 235
Опубликована: Янв. 19, 2025
Background: Chronic kidney disease (CKD) patients have an increased risk of cardiovascular (CVD), necessitating effective assessment methods. This study evaluates the calcium–phosphorus product (Ca × P) to estimated glomerular filtration rate P/eGFR) ratio as a potential biomarker for predicting CV in pre-dialysis CKD patients. Methods: Eighty-four stages G1–G4, according KDIGO criteria, were classified into CVD (n = 43) and non-CVD 41) groups. Biochemical parameters, including serum creatinine (SCr), blood urea nitrogen (BUN), calcium (Ca), inorganic phosphate (Pi), parathyroid hormone (PTH), alkaline phosphatase (ALP), Ca P, eGFR, P/eGFR ratio, measured calculated. Statistical analyses performed identify predictors evaluate diagnostic reliability risk. Results: Significant differences observed SCr, BUN, eGFR (p < 0.001), 0.007) between Regression analysis indicated significant predictor 0.012, OR 1.206, 95% CI: 1.042–1.395). Receiver Operating Characteristic (ROC) curve revealed AUC 0.751 0.001, 0.645–0.857), with sensitivity specificity method 74.4% 70.7%, respectively. correlations found UA, Ca, Pi, PTH, ALP. Conclusions: The may serve patients, suggesting that its integration routine evaluations could enhance stratification management.
Язык: Английский
Процитировано
0