Some
studies
have
suggested
that
uric
acid
has
antioxidant
properties
can
prevent
bone
loss,
but
the
relationship
between
and
mineral
density
is
controversial.
The
aim
of
this
study
was
to
investigate
UA
BMD
in
patients
with
CKD
stage
1-3.
Molecular Biomedicine,
Год журнала:
2025,
Номер
6(1)
Опубликована: Март 22, 2025
Abstract
Klotho,
initially
introduced
as
an
anti-aging
protein,
is
expressed
in
the
brain,
pancreas,
and
most
prominently
kidney.
The
two
forms
of
Klotho
(membrane-bound
soluble
form)
have
diverse
pharmacological
functions
such
anti-inflammatory,
anti-oxidative,
anti-fibrotic,
tumour-suppressive
etc.
membrane-bound
form
plays
a
pivotal
role
maintaining
kidney
homeostasis
by
regulating
fibroblast
growth
factor
23
(FGF
23)
signalling,
vitamin
D
metabolism
phosphate
balance.
deficiency
has
been
linked
with
significantly
reduced
protection
against
various
pathological
phenotypes,
including
diabetic
disease
(DKD),
which
major
cause
chronic
leading
to
end-stage
disease.
Owing
pleiotropic
actions
klotho,
it
shown
beneficial
effects
DKD
tackling
complex
pathophysiology
reducing
inflammation,
oxidative
stress,
well
fibrosis.
Moreover,
protective
effect
klotho
extends
beyond
other
conditions,
cardiovascular
diseases,
alzheimer's
disease,
cancer,
inflammatory
bowel
liver
Therefore,
this
review
summarizes
relationship
between
expression
diseases
special
emphasis
on
DKD,
distinct
mechanisms
potential
exogenous
supplementation
therapeutic
strategy.
Future
research
into
could
unravel
novel
treatment
avenues
for
diseases.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117050 - 117050
Опубликована: Июль 4, 2024
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
death
in
chronic
kidney
(CKD).
Hemodialysis
one
the
main
treatments
for
patients
with
end-stage
disease.
Epidemiological
data
has
shown
that
acute
myocardial
infarction
(AMI)
accounts
reason
CKD
under
hemodialysis
therapy.
Immune
dysfunction
and
changes
metabolism
(including
high
level
inflammatory
cytokines,
disorder
lipid
mineral
ion
homeostasis,
accumulation
uremic
toxins
et
al.)
during
can
deteriorate
stability
atherosclerotic
plaque
promote
vascular
calcification,
which
are
exactly
pathophysiological
mechanisms
underlying
occurrence
AMI.
Meanwhile,
itself
also
adverse
effects
on
lipoprotein,
immune
system
hemodynamics,
contribute
to
incidence
AMI
these
patients.
This
review
aims
summarize
further
promising
methods
prevention
treatment
undergoing
hemodialysis,
provide
an
excellent
paradigm
exploring
crosstalk
between
cardiovascular
system.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 5, 2024
Background:
Chronic
kidney
disease
(CKD)
is
now
globally
recognized
as
a
critical
public
health
concern.
Vascular
calcification
(VC)
represents
significant
risk
factor
for
cardiovascular
events
in
individuals
with
CKD.
It
the
accessible
and
precise
diagnostic
biomarkers
monitoring
progression
of
CKD
concurrent
VC
are
urgently
needed.
Methods:
The
adenine
diet-induced
rat
model
was
utilized
to
investigate
chronic
injury,
thoracic
aorta,
dysregulation
biochemical
indices.
Enzyme-linked
immune
sandwich
assays
were
employed
analyze
changes
calcification-related
proteins.
16S
rRNA
sequencing
performed
delineate
microbiota
characteristics
gut
blood
CKD-afflicted
rats.
Additionally,
transcriptome
tissue
conducted
explore
relationship
between
CKD-associated
features
alterations
function.
Results:
inhibited
body
weight
gain,
led
pronounced
aorta.
both
these
affected
rats
exhibited
significantly
lower
alpha
diversity
distinctive
beta
than
those
their
healthy
counterparts.
resulted
several
indices
(including
elevated
levels
creatinine,
low-density
lipoprotein-cholesterol,
sodium,
phosphorous,
total
cholesterol,
urea
decreased
albumin,
calcium,
lactate
dehydrogenase,
bilirubin).
Moreover,
it
upregulated
factors
(bone
sialoprotein
[BSP],
Klotho,
fibroblast
growth
[FGF]-23,
sclerostin
[SOST])
lipopolysaccharide
(LPS).
Notably,
increased
Acinetobacter
positively
associated
calcifications
addition
positive
correlation
microbiota.
enrichment
increases
(BSP,
FGF-23,
SOST),
LPS,
phosphorous.
Furthermore,
revealed
that
correlated
majority
genes
negatively
downregulated
involved
mineral
absorption
pathway.
Conclusion:
Our
findings,
first
time,
underscore
dysbiosis
symbiotic
microbiota,
blood,
Particularly,
emerges
potential
its
accompanying
VC.
Molecular Medicine,
Год журнала:
2023,
Номер
29(1)
Опубликована: Дек. 8, 2023
Abstract
N
6-methyladenosine
(m6A)
modification
is
a
kind
of
RNA
in
which
methylation
occurs
at
the
sixth
position
adenosine
RNA,
can
occur
various
RNAs
such
as
mRNAs,
lncRNAs
and
miRNAs.
This
one
most
prominent
frequent
posttranscriptional
modifications
within
organisms
has
been
shown
to
function
dynamically
reversibly
variety
ways,
including
splicing,
export,
attenuation
translation
initiation
efficiency
regulate
expression.
There
are
three
main
enzymes
associated
with
m6A
modification:
writers,
readers
erasers.
Increasing
evidence
that
onset
development
kidney
disease.
In
this
article,
we
address
important
physiological
pathological
roles
diseases
(uremia,
ischemia–reperfusion
injury,
drug-induced
diabetic
nephropathy)
its
molecular
mechanisms
provide
reference
for
diagnosis
clinical
management
diseases.
Expert Review of Cardiovascular Therapy,
Год журнала:
2023,
Номер
21(2), С. 75 - 85
Опубликована: Янв. 30, 2023
Introduction
Vascular
calcification
(VC)
which
is
the
pathological
mineral
deposition
in
vascular
system,
predominantly
at
intimal
and
medial
layer
of
vessel
wall,
an
important
comorbidity
patients
with
chronic
kidney
disease
(CKD)
leading
to
significant
morbidity
mortality
while
necessitating
appropriate
treatment.
Our
review
aims
provide
in-depth
analysis
current
understanding
VC.
International Journal of Endocrinology,
Год журнала:
2024,
Номер
2024, С. 1 - 7
Опубликована: Фев. 14, 2024
Objective.
This
study
aims
to
explore
the
relationships
between
serum
indoxyl
sulfate
(IS)
and
Klotho
protein
levels
with
vascular
calcification
in
patients
chronic
kidney
disease
(CKD)
stages
3–5.
Methods.
From
December
2021
January
2023,
a
total
of
108
CKD
3–5
were
enrolled
this
cross-sectional
investigation.
Demographic
information
routine
clinical
biochemistry
test
results
gathered.
Serum
IS
quantified
through
enzyme-linked
immunosorbent
assays.
Furthermore,
multislice
spiral
computed
tomography
was
employed
evaluate
calcification.
The
association
or
abdominal
aorta
assessed
using
univariate
analysis
logistic
regression
analyses.
Results.
With
progression
stages,
creatinine,
phosphorus,
intact
parathyroid
hormone
(iPTH),
IS,
aortic
exhibited
incremental
trends,
while
calcium
showed
diminishing
trend,
statistically
significant
differences
(
).
Significant
observed
age,
blood
calcium,
hormone,
without
id="M2">P<0.05
Logistic
demonstrated
that
advanced
high
level,
low
level
independent
risk
factors
for
id="M3">P<0.05
Conclusion.
indicates
elevated
decreased
patients.
High
Clinical Kidney Journal,
Год журнала:
2024,
Номер
17(6)
Опубликована: Июнь 1, 2024
The
global
derangement
of
mineral
metabolism
that
accompanies
chronic
kidney
disease
(CKD-MBD)
is
a
major
driver
the
accelerated
mortality
for
individuals
with
disease.
Advances
in
delivery
dialysis,
composition
phosphate
binders,
and
therapies
directed
towards
secondary
hyperparathyroidism
have
failed
to
improve
cardiovascular
event
profile
this
population.
Many
obstacles
prevented
progress
field
including
incomplete
understanding
pathophysiology,
lack
clinical
targets
early
stages
disease,
remarkably
wide
diversity
manifestations.
We
describe
review
novel
approach
CKD-MBD
combining
mathematical
modelling
biologic
processes
machine
learning
artificial
intelligence
techniques
as
tool
generation
new
hypotheses
development
innovative
therapeutic
approaches
syndrome.
Clinicians
need
alternative
therapy,
tools
risk
assessment,
address
complications
course
personalize
therapy
each
individual.
complexity
suggests
incorporating
into
diagnostic,
therapeutic,
research
armamentarium
could
accelerate
achievement
these
goals.
Endocrine Connections,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Metabolic
syndrome
(MetS)
is
associated
with
osteogenic
transdifferentiation
of
vascular
smooth
muscle
cells
(VSMC)
and
accumulation
arterial
calcifications
(AC).
Metformin
(MET)
inhibits
this
in
vitro.
Here,
we
evaluate
the
vivo
efficacy
oral
MET
to
reduce
AC
a
model
MetS.
20
young
male
Wistar
rats
were
divided
into
2
groups:
one
received
water,
other
water
plus
20%
fructose
induce
After
14
days,
for
another
4
weeks,
(100
mg/kg/day)
was
added
half
each
group’s
drinking
source,
thus:
C
(water),
F
(fructose),
M
FM
(fructose+MET).
Serum
adipose
tissue
collected.
Aortas
dissected
histomorphometric
immunohistochemical
analysis;
ex
calcification
studies;
isolate
VSMC
measure
their
alkaline
phosphatase
activity
(ALP),
collagen
production,
extracellular
mineralization,
gene
expression
RUNX2
RAGE
(receptor
AGEs),
elastic
fiber
production.
group
showed
parameters
compatible
Aortic
tunica
media
from
decreased
elastic-to-muscular
ratio,
increased
content
levels
AGEs
carboxymethyl-lysine.
arches
presented
tendency
higher
calcification.
ALP,
secretion,
mineralization
RAGE;
All
these
effects
reverted
by
co-treatment
(FM
group).
In
vitro,
AGEs-BSA
upregulated
control
VSMC,
prevented
an
AMPK-dependent
manner.
Thus,
experimental
MetS
induces
upregulation
aortic
that
curbed
treatment
MET.
Calcification
of
the
radial
artery
is
one
main
causes
anastomotic
stenosis
in
autogenous
arteriovenous
fistulas
uremic
patients.
However,
pathogenesis
calcification
still
unknown.
This
study
attempted
to
screen
and
validate
risk
factors
for
vascular
patients
with
uremia.
Serum
blood
were
collected
tissue
samples
from
obtained
60
uremia
or
without
hemodialysis.
General
biochemical
indicators
calcification-related
molecules
detected
via
ELISA
correlation
analysis.
In
addition,
pathological
changes
evaluated
by
HE
immunohistochemical
staining.
There
differences
total
calcium,
calcium-phosphorus
products,
allograft
inflammatory
factor
1
(AIF-1),
intact
parathyroid
hormone
(iPTH),
vitamin
D
(VD),
fibroblast
growth
23
(FGF23)
soluble
klotho
(sKlotho)
Furthermore,
these
are
related
artery.
The
expression
AIF-1,
PTHR1,
VDR,
FGF23
sKlotho
was
also
increased
calcified
levels
PTH,
serum
associated
further
aggravated
abnormalities
calcium
phosphorus
maintenance
hemodialysis