Research on the Relationship between Exosome Production and Atherosclerosis DOI
Yi Yang,

Jinxi Luo,

Yunan Kang

и другие.

Current Pharmaceutical Biotechnology, Год журнала: 2023, Номер 25(9), С. 1099 - 1111

Опубликована: Июль 26, 2023

Atherosclerosis (AS) is the leading cause of cardiovascular disease, causing a major burden on patients as well families and society. Exosomes generally refer to various lipid bilayer microvesicles originating from different cells that deliver bioactive molecules recipient cells, exerting biological effects in cellular communication thereby changing internal environment body. The mechanisms correlation between exosomes disease process atherosclerosis have been recently clarified. are rich nucleic acid proteins. For example, exosome miRNAs reportedly play important roles progression atherosclerotic diseases. In this review, we focus composition exosomes, mechanism their biogenesis release, commonly used methods for extraction. By summarizing latest research progress atherosclerosis, can explore advances provide new ideas targets prevention, diagnosis, treatment.

Язык: Английский

The role of biomechanical stress in extracellular vesicle formation, composition and activity DOI Creative Commons
Will Thompson,

Eleftherios T. Papoutsakis

Biotechnology Advances, Год журнала: 2023, Номер 66, С. 108158 - 108158

Опубликована: Апрель 26, 2023

Язык: Английский

Процитировано

33
Endothelial progenitor cell-derived extracellular vesicles: the world of potential prospects for the treatment of cardiovascular diseases DOI Creative Commons
Dexin Chen, Chuanghong Lu, Na Na

и другие.

Cell & Bioscience, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 5, 2024

Cardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortality rates of neoplastic diseases. Extracellular vesicles (EVs) serve vital mediators in intercellular communication material exchange. Endothelial progenitor cells (EPCs), recognized precursors vascular endothelial (ECs), garnered considerable attention recent years due potential therapeutic value their derived extracellular (EPC-EVs) context CVDs. This comprehensive review systematically explores origins, characteristics, functions EPCs, alongside classification, properties, biogenesis, extraction techniques EVs, with particular emphasis on protective roles Additionally, we delve into essential bioactive components EPC-EVs, including microRNAs, long non-coding RNAs, proteins, analyzing beneficial effects promoting angiogenesis, anti-inflammatory anti-oxidant activities, anti-fibrosis, anti-apoptosis, myocardial regeneration. Furthermore, this comprehensively investigates EPC-EVs across various CVDs, encompassing acute infarction, ischemia-reperfusion injury, atherosclerosis, non-ischemic cardiomyopathies, diabetic cardiovascular disease. Lastly, summarize challenges associated clinical application outline future directions, aiming offer valuable resource for both theoretical insights practical applications managing

Язык: Английский

Процитировано

8
Unraveling the Intricate Roles of Exosomes in Cardiovascular Diseases: A Comprehensive Review of Physiological Significance and Pathological Implications DOI Open Access

Shuai Zhang,

Yu Yang,

Xinchen Lv

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15677 - 15677

Опубликована: Окт. 27, 2023

Exosomes, as potent intercellular communication tools, have garnered significant attention due to their unique cargo-carrying capabilities, which enable them influence diverse physiological and pathological functions. Extensive research has illuminated the biogenesis, secretion, functions of exosomes. These vesicles are secreted by cells in different states, exerting either protective or harmful biological Emerging evidence highlights role cardiovascular disease (CVD) mediating comprehensive interactions among cell types. This review delves into impacts exosomes on CVD under stress conditions, including coronary artery (CAD), myocardial infarction, heart failure, other cardiomyopathies. Focusing cellular signaling mechanisms, we explore how mediate multifaceted interactions, particularly contributing endothelial dysfunction, oxidative stress, apoptosis pathogenesis. Additionally, show great promise biomarkers, reflecting differential expressions NcRNAs (miRNAs, lncRNAs, circRNAs), therapeutic carriers for targeted treatment. However, specific regulatory mechanisms governing remain incomplete, necessitating further exploration characteristics roles various CVD-related contexts. aims provide novel insights implications offer innovative perspectives diagnosis treatment CVD.

Язык: Английский

Процитировано

14
Natural medicines target tumor vascular microenvironment to inhibit tumor DOI Creative Commons

Yirui Lu,

Zhiliang Guo,

Hong Li

и другие.

Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101623 - 101623

Опубликована: Апрель 1, 2025

Процитировано

0
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases DOI
Kyung‐Sun Heo, Lon Phan, Nhung Le

и другие.

Archives of Pharmacal Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0
Advances in regulating endothelial-mesenchymal transformation through exosomes DOI Creative Commons

Sun Sishuai,

Gu Lingui,

Li PengTao

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 31, 2024

Endothelial-mesenchymal transformation (EndoMT) is the process through which endothelial cells transform into mesenchymal cells, affecting their morphology, gene expression, and function. EndoMT a potential risk factor for cardiovascular cerebrovascular diseases, tumor metastasis, fibrosis. Recent research has highlighted role of exosomes, mode cellular communication, in regulation EndoMT. Exosomes from diseased tissues microenvironments can promote EndoMT, increase permeability, compromise vascular barrier. Conversely, exosomes derived stem or progenitor inhibit preserve By modifying exosome membranes contents, we harness advantages as carriers, enhancing targeting ability to This review aims systematically summarize by different disease contexts provide effective strategies exosome-based intervention.

Язык: Английский

Процитировано

1
NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3 DOI
Jianwei Chen, Xiaoyu Liu, Ran Bi

и другие.

Neuroreport, Год журнала: 2023, Номер 34(13), С. 670 - 676

Опубликована: Июль 23, 2023

Ischemic stroke is the main type of cerebrovascular disease. Emergency thrombectomy combined with medication therapy currently primary treatment for stroke. Inflammation and oxidative stress induced by ischemia-reperfusion cause secondary damage to blood vessels, especially endothelial mesenchymal transformation (EndoMT). However, much still unclear about role EndoMT in ischemia-reperfusion. In this study, an vivo model was established transient middle cerebral artery occlusion (tMCAO) wild-type (WT) C57BL/6 mice NLRP3 (NOD-like receptor thermal protein domain associated 3) knockout (KO) mice. An vitro oxygen glucose deprivation reoxygenation (OGD/R) human brain microvascular cells (HBMECs). α-SMA (alpha smooth muscle actin), CD31 (platelet cell adhesion molecule-1, PECAM-1/CD31), NDUFC2 (NADH: ubiquinone oxidoreductase subunit C2), were used evaluate inflammation. Real-time PCR measured superoxide dismutase 1 (SOD1) catalase (CAT) mRNA expression levels. activated injury inactivation inhibited tMCAO Further experiments demonstrated that OGD/R activation HBMECs, which resulted deficiency. overexpression suppressed HBMECs OGD/R. Moreover, rescued SOD1 CAT expression. These results deficiency decreased antioxidant levels, leading during suggesting a potential drug target ischemic

Язык: Английский

Процитировано

2
Linc-ROR Modulates the Endothelial-Mesenchymal Transition of Endothelial Progenitor Cells through the miR-145/Smad3 Signaling Pathway DOI Creative Commons
Jing Liang, Haiyan Chu, Ran Yan

и другие.

Physiological Research, Год журнала: 2024, Номер unknown, С. 565 - 576

Опубликована: Авг. 31, 2024

The endothelial-mesenchymal transition (EndMT) of endothelial progenitor cells (EPCs) plays a notable role in pathological vascular remodeling. Emerging evidence indicated that long non-coding RNA-regulator reprogramming (linc-ROR) can promote epithelial-mesenchymal (EMT) variety cancer cells. Nevertheless, the function linc-ROR EPC EndMT has not been well elucidated. present study investigated effect and possible mechanisms on EPCs. A overexpression lentiviral vector (LV linc-ROR) or short hairpin RNA (LV-shlinc-ROR) was used to up downregulate expression EPCs isolated from human umbilical cord blood. Functional experiments demonstrated LV-linc-ROR promoted proliferation migration EPCs, but inhibited angiogenesis vitro. In meantime, reverse transcription-quantitative PCR western blotting results showed cell markers endothelial-cadherin CD31 decreased, while mesenchymal ?-smooth muscle actin SM22? increased at both mRNA protein levels LV-linc-ROR-treated indicating induced EndMT. Mechanistically, dual-luciferase reporter assay microRNA (miR/miRNA)-145 direct target linc-ROR, miR-145 binds 3'-untranslated region Smad3. Moreover, LV-shlinc-ROR miR-145, decreased conclusion, promotes EndMT, which may be associated with miR-145/Smad3 signaling pathway. Keywords: Endothelial cells, transition, Linc-ROR, MiR-145, Atherosclerosis.

Язык: Английский

Процитировано

0
Extracellular vesicles originating from the mechanical microenvironment in the pathogenesis and applications for cardiovascular diseases DOI Creative Commons

Yu Zeng,

Xiaodong Cui, Hong Li

и другие.

Regenerative Therapy, Год журнала: 2024, Номер 26, С. 1069 - 1077

Опубликована: Июнь 1, 2024

The mechanical microenvironment plays a crucial regulatory role in the growth and development of cells. Mechanical stimuli, including shear, tensile, compression, extracellular matrix forces, significantly influence cell adhesion, migration, proliferation, differentiation, various other cellular functions. Extracellular vesicles (EVs) are involved numerous physiological pathological processes, with their occurrence secretion being strictly regulated by microenvironment. Recent studies have confirmed that alterations present cardiovascular diseases, components EVs can respond to changes signals, thereby impacting progression these diseases. Additionally, engineered EVs, created leveraging microenvironments, serve as natural drug-delivery vehicles for treating managing specific This article systematically reviews mechanisms through which influences summarizes advancements derived from this environment context

Язык: Английский

Процитировано

0
Research on the Relationship between Exosome Production and Atherosclerosis DOI
Yi Yang,

Jinxi Luo,

Yunan Kang

и другие.

Current Pharmaceutical Biotechnology, Год журнала: 2023, Номер 25(9), С. 1099 - 1111

Опубликована: Июль 26, 2023

Atherosclerosis (AS) is the leading cause of cardiovascular disease, causing a major burden on patients as well families and society. Exosomes generally refer to various lipid bilayer microvesicles originating from different cells that deliver bioactive molecules recipient cells, exerting biological effects in cellular communication thereby changing internal environment body. The mechanisms correlation between exosomes disease process atherosclerosis have been recently clarified. are rich nucleic acid proteins. For example, exosome miRNAs reportedly play important roles progression atherosclerotic diseases. In this review, we focus composition exosomes, mechanism their biogenesis release, commonly used methods for extraction. By summarizing latest research progress atherosclerosis, can explore advances provide new ideas targets prevention, diagnosis, treatment.

Язык: Английский

Процитировано

0