Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Апрель 29, 2024

Abstract Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses transcriptomic changes in adipose tissue were performed to elucidate interactive effects between high-fat diet-induced obesity (DIO) TBI. Adult male mice fed a diet (HFD) for 12 weeks prior experimental TBI continuing after injury. High-throughput analysis using Nanostring panels total visceral (VAT) cellular components brain, followed by unsupervised clustering, principal component analysis, IPA pathway used determine shifts gene expression patterns molecular activity. Cellular populations cortex hippocampus, as well VAT, during chronic phase combined TBI-HFD showed amplification central peripheral microglia/macrophage responses, including superadditive selected signatures pathways. Furthermore, HFD caused additive dysfunction Y-Maze, Novel Object Recognition (NOR), Morris water maze (MWM) cognitive function tests. These novel data suggest that HFD-induced can independently prime support development altered states microglia disease-associated (DAM) phenotype observed neurodegenerative disorders. The interaction promotes shift toward reactive associated pro-inflammatory disease-altered may, part, underlie exacerbation deficits. Thus, targeting phenotypes, immune cell populations, may serve reduce microglial maladaptive TBI, attenuating post-traumatic neurodegeneration neurological dysfunction.

Язык: Английский

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GLP-1 programs the neurovascular landscape

Cell Metabolism, Год журнала: 2024, Номер 36(10), С. 2173 - 2189

Опубликована: Окт. 1, 2024

Язык: Английский

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Metabolic disorders after traumatic brain injury: a narrative review of systemic consequences

Metabolic Brain Disease, Год журнала: 2025, Номер 40(1)

Опубликована: Янв. 7, 2025

Язык: Английский

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A long-term mild high-fat diet facilitates rabbit discrimination learning and alters glycerophospholipid metabolism

Neurobiology of Learning and Memory, Год журнала: 2025, Номер unknown, С. 108053 - 108053

Опубликована: Апрель 1, 2025

Язык: Английский

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The importance of behavioral interventions in traumatic brain injury

Surgical Neurology International, Год журнала: 2024, Номер 15, С. 22 - 22

Опубликована: Янв. 26, 2024

Background: Traumatic brain injury (TBI) poses a significant public health concern, profoundly impacting individuals and society. In this context, behavioral interventions have gained prominence as crucial elements in TBI management, addressing the diverse needs of TBI-affected individuals. Methods: A comprehensive literature search was conducted, utilizing databases such PubMed, Embase, Scopus. Inclusion criteria encompassed studies focusing on TBI, with particular emphasis their impact outcomes. Relevant articles published within past decade were prioritized, qualitative synthesis findings performed. Results: Behavioral demonstrated effectiveness various aspects care. They been instrumental improving cognitive functions, emotional stability, adaptive behaviors among patients. However, it is important to acknowledge that challenges still exist, including issues related clinical heterogeneity healthcare disparities. Conclusion: The integration into standard practice marks transformative shift This approach holds immense potential for enhancing patient outcomes elevating overall quality life grappling complexities condition. review serves clarion call practitioners, researchers, policymakers recognize pivotal role care, advocating wider adoption advance field toward more holistic patient-centric approach.

Язык: Английский

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Overlapping and Distinct Physical and Biological Phenotypes Related to Pure Frailty and Frail Obesity

Bioscience Reports, Год журнала: 2024, Номер 44(11)

Опубликована: Окт. 9, 2024

Pure frailty and obese are common types of syndrome. However, the overlapping distinct characteristics between pure remain unclear. This study aims to reveal overlapping/distinct physical biological phenotypes frailty, providing theoretical support for their prevention, diagnosis, treatment.

Язык: Английский

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Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 29, 2023

Obesity increases the morbidity and mortality of traumatic brain injury (TBI). We performed a detailed analysis transcriptomic changes in adipose tissue to examine interactive effects between high-fat diet-induced obesity (DIO) TBI relation central peripheral inflammatory pathways, as well neurological function. Adult male mice were fed diet (HFD) for 12 weeks prior experimental continuing after injury. Combined HFD resulted additive dysfunction Y-Maze, novel object recognition (NOR), Morris water maze (MWM) cognitive function tests. also high-throughput using Nanostring panels cellular compartments total visceral (VAT), followed by unsupervised clustering, principal component analysis, IPA pathway determine shifts gene expression programs molecular activity. Analysis populations cortex hippocampus during chronic phase combined TBI-HFD showed amplification microglia/macrophage responses, including superadditive select signatures pathways. These data suggest that HFD-induced can independently prime support development altered states microglia macrophages, disease-associated (DAM) phenotype observed neurodegenerative disorders. The interaction promotes shift toward reactive associated pro-inflammatory disease-altered may, part, underlie exacerbation deficits. Targeting phenotypes, may serve reduce microglial maladaptive TBI, attenuating post-traumatic neurodegeneration dysfunction.

Язык: Английский

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The Western Diet Puzzle: Connecting Metabolic Dysfunction to Cognitive and Neurological Consequences

Опубликована: Янв. 1, 2024

Язык: Английский

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Applying Dynamical Systems Theory to Improve Personalized Medicine Following Mild Traumatic Brain Injury

Neurotrauma Reports, Год журнала: 2024, Номер 5(1), С. 671 - 679

Опубликована: Май 1, 2024

A sizable proportion of patients with mild traumatic brain injury (mTBI) have persistent symptoms and functional impairments months to years following injury. This phenomenon is continually observed despite an explosion research interest in improving mTBI clinical outcomes over the last two decades. All pharmacological trials date failed demonstrate improved for mTBI. One possible explanation these continued failures overly myopic approach treating (i.e., testing effect a single drug specific mechanism on group people highly heterogenous injuries). Clinical presentation prognosis vary considerably between patients, yet we continue assess group-level effects homogenized treatment. We need utilize equally complex treatment match extraordinary complexity human brain. Dynamical systems theory has been used describe composed multiple subsystems who function somewhat independently but are ultimately interconnected. was popularized motor control literature as overarching framework how mind body connect interact move through environment. However, can be viewed dynamical system organ systems) isolated functions, which also codependent health performance other interconnected systems. In this perspective piece, will use example obese patient broadening our individual (and not necessarily injury) may yield outcomes. Furthermore, explore pre-clinical evidence demonstrating interactions context obesity TBI discuss expanding understanding mechanistic interplay provide more personalized subpopulation.

Язык: Английский

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Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury

Journal of Neurorestoratology, Год журнала: 2024, Номер 12(3), С. 100140 - 100140

Опубликована: Июль 27, 2024

Traumatic brain injury (TBI) and lifestyle habits such as Western diet (WD) consumption represent two risk factors that affect an individual's health outcome globally. Individuals with TBI have a greater of mortality from associated chronic diseases than the general population. WD has been shown to impair cognitive function, decrease brain's capacity compensate for insult by affecting recovery well induce metabolic syndrome (MetS) which may be factor poor prognosis. Hence, this study aims investigate impact on behavioral outcomes neuropathology. Eight-week-old male C57BL6 mice were fed either or normal chow 4 weeks prior induction. At week four, underwent experimental open-head sham procedure. Mice continued their respective diets four after injury. Metabolic, molecular assessment performed TBI. Results showed while significantly increased fat percentage elevated plasma cholesterol, there was no change in blood glucose level body weight, indicating early stage MetS. Nevertheless, neuroinflammation impaired functions. However, significant cardiovascular function mitochondrial bioenergetics. Importantly, mild MetS induced triggered basal motor, deterioration exacerbated long-term neuropathology Taken together, our work highlights magnitude contribution including type diet, even absence overt consequences, neurobehavioral prognosis following

Язык: Английский

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