World Journal of Gastrointestinal Surgery,
Год журнала:
2024,
Номер
16(8), С. 2521 - 2527
Опубликована: Авг. 16, 2024
BACKGROUND
Gastric
cancer
is
one
of
the
most
common
malignant
tumors
worldwide,
and
surgical
resection
main
ways
to
treat
gastric
cancer.
However,
immune
status
postoperative
patients
crucial
for
prognosis
survival,
cells
play
an
important
role
in
this
process.
Therefore,
it
helpful
understand
by
evaluating
levels
peripheral
blood
cells,
especially
total
T
(CD3+),
helper
(CD3+CD4+),
suppressor
(CD3+CD8+),
its
relationship
survival.
AIM
To
analyzed
with
after
surgery,
detect
cells.
METHODS
A
58
who
received
treatment
were
included
retrospective
study.
Flow
cytometry
was
used
level
analyze
correlation
between
inhibitory
explore
these
markers
patient
RESULTS
The
results
showed
that
changed
surgery.
There
a
significant
positive
(r
=
0.35,
P
<
0.01;
r
0.56,
0.01).
there
negative
-0.63,
Follow-up
survival
rate
high-level
cell
group
significantly
higher
than
low-level
(28.87
±
24.98
months
vs
18.42
16.21
months).
curve
shows
shifted
upper
right,
downward.
no
difference
time.
CONCLUSION
By
detecting
flow
cytometry,
we
can
initially
evaluate
surgery
World Journal of Gastrointestinal Oncology,
Год журнала:
2025,
Номер
17(3)
Опубликована: Фев. 13, 2025
BACKGROUND
Immunotherapy
has
surfaced
as
a
promising
therapeutic
modality
for
gastric
cancer
(GC).
A
comprehensive
review
of
advancements,
current
status,
and
research
trends
in
GC
immunotherapy
is
essential
to
inform
future
investigative
efforts.
AIM
To
delineate
the
trends,
focal
points
GC.
METHODS
We
performed
bibliometric
analysis
2906
articles
English
concerning
published
from
2000
December
20,
2023,
indexed
Web
Science
Core
Collection.
Data
visualization
were
facilitated
by
CiteSpace
(6.1.6R),
VOSviewer
v.1.6.17,
GraphPad
Prism
v8.0.2.
RESULTS
There
been
an
increase
annual
publication
rate
research.
China
leads
volume,
while
United
States
demonstrates
highest
citation
impact.
Fudan
University
notable
its
frequency
output.
Co-citation
keyword
revealed
highlighted
focus
on
prognosis,
tumor
microenvironment
(TME),
integrative
with
targeted
therapy.
Emerging
areas
include
gastroesophageal
junction
cancer,
adoptive
immunotherapy,
role
Treg
cell
immunotherapy.
CONCLUSION
expanding
field
attracting
considerable
scientific
interest.
With
clinical
adoption
GC,
primary
goals
are
enhance
treatment
efficacy
patient
outcomes.
Unlike
hematological
malignancies,
GC's
solid
TME
presents
distinct
immunological
challenges
that
may
attenuate
cytotoxic
effects
immune
cells
cells.
For
instance,
although
CAR-T
therapy
effective
it
underperformed
settings.
Current
centered
overcoming
immunosuppression
within
TME,
combinations
therapy,
dynamics,
precise
prognosis
prediction
Additionally,
immunotherapy's
treating
become
novel
focus.
World Journal of Surgical Oncology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 7, 2025
Locally
advanced
gastric
cancer
(LAGC)
is
challenging
to
treat,
with
neoadjuvant
chemotherapy
(NCT)
improving
survival.
Recent
advances
suggest
that
immunochemotherapy
(NICT)
may
enhance
treatment
outcomes.
This
study
compares
the
efficacy
and
safety
of
NICT
NCT
in
LAGC
patients
who
received
radical
surgery.
We
retrospectively
analyzed
67
treated
at
China-Japan
Friendship
Hospital
from
January
2023
2024.
Patients
were
divided
into
two
groups:
(chemotherapy
plus
PD-1/PD-L1
inhibitors)
(standard
chemotherapy).
compared
pathological
complete
response
(pCR),
postoperative
recovery,
complications,
laboratory
markers.
The
group
demonstrated
a
significantly
higher
pCR
rate
(25.7%
vs.
6.2%,
P
=
0.032)
group.
Furthermore,
showed
reduced
rates
nerve
vascular
invasion
(28.6%
31.4%,
0.041).
Tumor
regression
grades
(P
0.001)
more
favorable
group,
earlier
ypN
ypTNM
stages
0.001).
Laboratory
analysis
revealed
greater
reduction
tumor
markers
CEA
CA19-9
groups,
decreased
white
blood
cell
counts
elevated
liver
enzymes.
Surgical
outcomes,
including
operative
time,
loss,
hospital
stay,
similar
between
no
significant
increase
complications
effective
than
traditional
responses
reducing
burden
patients.
It
also
without
increasing
surgical
risks.
Sakarya Üniversitesi Holistik Sağlık Dergisi,
Год журнала:
2025,
Номер
8(1), С. 61 - 70
Опубликована: Апрель 30, 2025
Cancer
is
recognized
as
one
of
the
most
significant
non-communicable
diseases
health
concerns
on
a
global
scale
posing
substantial
burden.
In
2020,
it
accounted
for
19.3
million
newly
diagnosed
cases
and
10
fatalities
worldwide.
While
early
diagnosis
awareness
are
more
prevalent
in
developed
countries,
cancer
often
detected
at
advanced
stages
developing
nations.
Turkey,
lung,
breast,
colorectal
cancers
among
common
types.
Nurses
play
vital
role
identifying
risk
factors,
raising
public
awareness,
providing
preventive
care.
Their
responsibilities
screening
processes,
including
coordination,
patient
education,
advocacy,
critical
fight
against
cancer.
Strengthening
these
roles
considered
an
essential
strategy
prevention
control.
Based
this
information,
aim
review
to
analyze
national
prevalence
cancer,
types,
evaluate
nurses
processes.
Life Sciences,
Год журнала:
2023,
Номер
337, С. 122379 - 122379
Опубликована: Дек. 23, 2023
Gastric
cancer
contributes
to
cancer-related
fatalities.
Conventional
chemotherapy
faces
challenges
due
severe
adverse
effects,
prompting
recent
research
focus
on
postbiotics,
which
are
safer
biomolecules
derived
from
nonviable
probiotics.
Despite
promising
in
vitro
results,
efficient
vivo
delivery
systems
remain
a
challenge.
This
study
aimed
design
potential
nanoparticle
(NP)
formulation
encapsulating
the
Lacticaseibacillus
paracasei
GMNL-133
(SGMNL-133)
isolate
enhance
its
therapeutic
efficacy
treating
gastric
cancer.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117229 - 117229
Опубликована: Авг. 2, 2024
Enormous
patients
with
gastric
cancer
(GC)
are
insensitive
to
chemotherapy
and
targeted
therapy
without
the
chance
of
radical
surgery,
so
immunotherapy
may
supply
a
novel
choice
for
them.
Chimeric
antigen
receptor
(CAR)-T
cell
has
advantages
higher
specificity,
stronger
lethality,
longer-lasting
efficacy,
it
potential
GC
in
future.
However,
its
application
still
faces
numerous
obstacles
terms
accuracy,
safety.
Cytokines
can
mediate
migration,
proliferation,
survival
immune
cells,
regulate
duration
strength
responses,
involved
occurrence
severe
side
effects
CAR-T
therapy.
The
expression
levels
specific
cytokines
associated
genesis,
invasion,
metastasis,
prognosis
GC.
Applications
their
receptors
have
emerged,
various
contributed
improving
anti-tumor
capabilities.
Large
amounts
central
this
include
chemokines,
interleukins
(ILs),
transforming
growth
factor-β
(TGF-β),
colony-stimulating
factors
(CSFs).
Meanwhile,
researchers
explored
combination
treating
GC,
several
approaches
applied
other
malignancies
also
be
considered
as
references.
Therefore,
our
review
comprehensively
outlines
biological
functions
clinical
significance
summarizes
current
advances
innovative
strategies
harnessing
optimize
Precision Clinical Medicine,
Год журнала:
2024,
Номер
7(4)
Опубликована: Сен. 19, 2024
Abstract
Gastric
cancer
is
a
malignant
tumor
that
ranks
third
in
cancer-related
deaths
worldwide.
Early-stage
gastric
can
often
be
effectively
managed
through
surgical
resection.
However,
the
majority
of
cases
are
diagnosed
advanced
stages,
where
outcomes
with
conventional
radiotherapy
and
chemotherapy
remain
unsatisfactory.
Immunotherapy
offers
novel
approach
to
treating
molecularly
heterogeneous
by
modifying
immunosuppressive
microenvironment.
Immune
checkpoint
inhibitors
adoptive
cell
therapy
regarded
as
promising
modalities
immunotherapy.
Food
Drug
Administration-approved
programmed
death-receptor
inhibitors,
such
pembrolizumab,
combination
chemotherapy,
have
significantly
extended
overall
survival
patients
recommended
first-line
treatment.
Despite
challenges
solid
applications,
has
demonstrated
efficacy
against
various
targets
Among
these
approaches,
chimeric
antigen
receptor-T
research
most
widely
explored
targeting
claudin18.2
shown
acceptable
safety
robust
anti-tumor
capabilities.
advancements
primarily
preclinical
stages
further
investigation
should
made
promote
their
clinical
application.
This
review
summarizes
latest
on
immune
limitations,
well
role
nanoparticles
enhancing
iScience,
Год журнала:
2023,
Номер
26(10), С. 107871 - 107871
Опубликована: Сен. 9, 2023
Most
gastric
cancer
(GC)
subtypes
are
identified
through
transcriptional
profiling
overlooking
dynamic
changes
and
interactions
in
gene
expression.
Based
on
the
background
network
of
global
immune
genes,
we
constructed
sample-specific
edge-perturbation
matrices
four
molecular
GC
(MNG).
MNG-1
displayed
best
prognosis
vigorous
cell
cycle
activity.
MNG-2
was
enriched
by
immune-hot
phenotype
with
potential
for
immunotherapy
response.
MNG-3
MNG-4
were
epithelial-mesenchymal
transition
(EMT)
peculiarity
worse
prognosis,
termed
EMT
subtypes.
characterized
low
mutational
burden
stromal
cells
considered
a
replica
previous
associated
poor
prognosis.
Notably,
previously
undefined
subtype
dismal
chromosomal
instability
immune-desert
microenvironment.
This
tended
to
metastasize
resistant
respond
immunotherapy.
Pharmacogenomics
analysis
showed
three
therapeutic
agents
(NVP-BEZ235,
LY2606368,
rutin)
interventions
MNG-4.
World Journal of Clinical Oncology,
Год журнала:
2024,
Номер
15(11), С. 1383 - 1389
Опубликована: Окт. 12, 2024
Gastric
cancer
continues
to
be
a
significant
issue
for
public
health,
marked
by
its
widespread
occurrence
and
high
mortality
rates,
even
as
the
incidence
of
disease
shows
declining
trend.
The
liver
is
primary
site
metastatic
spread,
with
peritoneum,
lungs,
bones
also
being
common
targets.
With
advent
biologic
treatments
introduction
immunotherapy
patients
conditions,
options
treat
gastric
have
expanded.
This
diversified
therapeutic
approach
designed
enhance
patient
quality
life
prolong
survival,
showcasing
progress
in
treatment
modalities
individuals
metastases.
