Drug Development Research,
Год журнала:
2024,
Номер
85(7)
Опубликована: Окт. 17, 2024
Abstract
Gastric
cancer
(GC)
a
prevalent
form
of
globally.
Previous
research
suggests
that
SHOX2
may
have
role
in
promoting
progression.
However,
the
GC
is
not
well
understood.
Based
on
data
from
TCGA_GC
set,
SHXO2
levels
were
examined
normal
and
tissues.
Patients
cohort
divided
into
high‐
low‐SHOX2
level
groups
for
analysis
overall
survival
(OS),
functional
enrichment,
immune
infiltration.
Furthermore,
experiments
conducted
to
investigate
impact
cell
function
through
gain‐
loss‐of‐function
experiments.
Utilizing
public
databases,
mRNA
found
be
elevated
tissues
compared
control,
this
finding
was
confirmed
by
RT‐qPCR,
western
blot
analysis,
immune‐histochemical
analyses.
Elevated
could
serve
as
an
independent
indicator
poor
prognosis
patients.
had
negative
correlation
with
CD8
T
cells
CD4
memory
activated
cells,
positive
M0
macrophages
Functional
analyses
revealed
deficiency
notably
suppressed
proliferation,
migration,
invasion.
Additionally,
shown
suppress
stemness
vitro
vivo
via
inactivating
wnt/β‐catenin
signaling.
Collectively,
prognostic
marker
patients,
downregulation
effectively
impede
growth
signaling
pathway.
These
findings
underscore
potential
promising
therapeutic
target
GC.
Current Medicinal Chemistry,
Год журнала:
2023,
Номер
31(21), С. 3198 - 3216
Опубликована: Ноя. 6, 2023
Purpose::
The
expression
level
of
programmed
death
ligand-1(PD-L1)
in
patients
with
gastric
cancer
is
the
key
to
determining
use
immune
drugs.
relationship
between
PD-L1
and
clinical
characteristics
worth
exploring.
Methods::
By
setting
search
terms
correlated
cancer,
a
nearly
comprehensive
was
carried
out
four
major
databases,
deadline
for
searching
September
1,
2022.
retrieved
documents
were
further
screened
by
strict
inclusion
exclusion
criteria
after
removing
duplication.
Next,
quality
included
studies
evaluated
Newcastle-Ottawa
Scale
(NOS)
scale.
Finally,
STATA15.1
software
used
process
data
draw
plots,
odds
ratios
(ORs)
adopted
assess
pooled
effect
size.
Results::
A
total
85
works
literature
this
study
through
screening
strictly,
detailed
extracted
evaluating
literature.
analysis
conducted
whole
population,
Asia-Africa
European
American
Asian
population
CPS≥1,
amd
all
found
that
age,
tumor
size,
EBV
infection,
Her-2
microsatellite
status.
However,
subgroup
region
also
some
differences
Western
regions,
which
interesting
studying
further.
research
did
not
have
significant
publish
bias.
Conclusion::
After
careful
analysis,
age
(>60
years),
size
(>5cm),
infection
(+),
status
(MSI),
mismatch
repair
(dMMR)
risk
factors
positive
cancer.
World Journal of Surgical Oncology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 24, 2024
Abstract
Background
The
aim
of
this
study
was
to
elucidate
the
histogenesis
and
genetic
underpinnings
fibromatosis-like
undifferentiated
gastric
carcinoma
(FLUGC),
a
rare
pathological
entity.
Method
Through
detailed
analysis
seven
cases,
including
histopathological
evaluation,
CTNNB1
gene
mutation
screening,
human
epidermal
growth
factor
receptor
2
(HER2)
protein
level
quantification,
HER2
amplification
assessment
identify
molecular
characteristics
FLUGC.
Results
Of
patients
in
study,
five
were
male
two
female
(age:
39–73
years).
Four
presented
with
lesions
antrum
three
had
lateral
curvature
stomach.
Histopathologically,
over
90%
tumor
consisted
aggressive
tissue,
proliferating
spindle
fibroblasts
myofibroblasts
varying
amounts
collagenous
fibrous
tissues.
Undifferentiated
cancer
cells,
accounting
for
less
than
10%,
dispersed
among
These
cells
characterized
by
their
small
size
relatively
sparse
without
glandular
ducts
or
nested
mass-like
structures.
Immunophenotyping
results
showed
positive
expression
CKpan,
CDX2,
villin,
p53
cells;
vimentin
tissue;
cytoplasmic
β-catenin;
focal
smooth
muscle
actin
(SMA).
Genetic
did
not
reveal
any
mutations
test,
nor
there
fluorescence
situ
hybridization
(FISH)
test.
Additionally,
Epstein-Barr
encoding
region
(EBER)
negative;
mismatch
repair
(MMR)
positive.
Programmed
cell
death-1
(PD-1)
<
1–5%;
programmed
death
ligand
1
(PD-L1):
TPS
=
1–4%,
CPS
3–8.
Conclusion
highlights
significance
CTNNB1,
HER2,
EBER,
MMR
as
pivotal
markers
FLUGC,
underscoring
relevance
diagnosis
clinical
management.
rarity
distinct
features
FLUGC
emphasize
importance
accurate
prevent
underdiagnosis
misdiagnosis
raise
awareness
within
medical
community.
World Journal of Gastrointestinal Surgery,
Год журнала:
2024,
Номер
16(8), С. 2521 - 2527
Опубликована: Авг. 16, 2024
BACKGROUND
Gastric
cancer
is
one
of
the
most
common
malignant
tumors
worldwide,
and
surgical
resection
main
ways
to
treat
gastric
cancer.
However,
immune
status
postoperative
patients
crucial
for
prognosis
survival,
cells
play
an
important
role
in
this
process.
Therefore,
it
helpful
understand
by
evaluating
levels
peripheral
blood
cells,
especially
total
T
(CD3+),
helper
(CD3+CD4+),
suppressor
(CD3+CD8+),
its
relationship
survival.
AIM
To
analyzed
with
after
surgery,
detect
cells.
METHODS
A
58
who
received
treatment
were
included
retrospective
study.
Flow
cytometry
was
used
level
analyze
correlation
between
inhibitory
explore
these
markers
patient
RESULTS
The
results
showed
that
changed
surgery.
There
a
significant
positive
(r
=
0.35,
P
<
0.01;
r
0.56,
0.01).
there
negative
-0.63,
Follow-up
survival
rate
high-level
cell
group
significantly
higher
than
low-level
(28.87
±
24.98
months
vs
18.42
16.21
months).
curve
shows
shifted
upper
right,
downward.
no
difference
time.
CONCLUSION
By
detecting
flow
cytometry,
we
can
initially
evaluate
surgery
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 5, 2024
Immunotherapy
has
profoundly
changed
the
treatment
of
gastric
cancer,
but
only
a
minority
patients
benefit
from
immunotherapy.
Therefore,
numerous
studies
have
been
devoted
to
clarifying
mechanisms
underlying
resistance
immunotherapy
or
developing
biomarkers
for
patient
stratification.
However,
previous
focused
mainly
on
tumor
microenvironment.
Systemic
immune
perturbations
long
observed
in
with
and
involvement
peripheral
system
effective
anticancer
responses
attracted
much
attention
recent
years.
understanding
distinct
types
systemic
organization
cancer
will
aid
personalized
designed
pair
traditional
therapies
alleviate
their
detrimental
effects
immunity
directly
activate
response
immunity.
Herein,
this
review
aims
comprehensively
summarize
including
induced
by
therapies,
potential
clinical
applications
detection,
prediction,
prognosis
therapy
cancer.
Drug Development Research,
Год журнала:
2024,
Номер
85(7)
Опубликована: Окт. 17, 2024
Abstract
Gastric
cancer
(GC)
a
prevalent
form
of
globally.
Previous
research
suggests
that
SHOX2
may
have
role
in
promoting
progression.
However,
the
GC
is
not
well
understood.
Based
on
data
from
TCGA_GC
set,
SHXO2
levels
were
examined
normal
and
tissues.
Patients
cohort
divided
into
high‐
low‐SHOX2
level
groups
for
analysis
overall
survival
(OS),
functional
enrichment,
immune
infiltration.
Furthermore,
experiments
conducted
to
investigate
impact
cell
function
through
gain‐
loss‐of‐function
experiments.
Utilizing
public
databases,
mRNA
found
be
elevated
tissues
compared
control,
this
finding
was
confirmed
by
RT‐qPCR,
western
blot
analysis,
immune‐histochemical
analyses.
Elevated
could
serve
as
an
independent
indicator
poor
prognosis
patients.
had
negative
correlation
with
CD8
T
cells
CD4
memory
activated
cells,
positive
M0
macrophages
Functional
analyses
revealed
deficiency
notably
suppressed
proliferation,
migration,
invasion.
Additionally,
shown
suppress
stemness
vitro
vivo
via
inactivating
wnt/β‐catenin
signaling.
Collectively,
prognostic
marker
patients,
downregulation
effectively
impede
growth
signaling
pathway.
These
findings
underscore
potential
promising
therapeutic
target
GC.
