Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective

Phytomedicine, Год журнала: 2023, Номер 122, С. 155142 - 155142

Опубликована: Окт. 11, 2023

Язык: Английский

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COVID-19 annual update: a narrative review

Human Genomics, Год журнала: 2023, Номер 17(1)

Опубликована: Июль 24, 2023

Abstract Three and a half years after the pandemic outbreak, now that WHO has formally declared emergency is over, COVID-19 still significant global issue. Here, we focus on recent developments in genetic genomic research COVID-19, give an outlook state-of-the-art therapeutical approaches, as gradually transitioning to endemic situation. The sequencing characterization of rare alleles different populations made it possible identify numerous genes affect either susceptibility or severity disease. These findings provide beginning new avenues pan-ethnic therapeutic well potential screening protocols. causative virus, SARS-CoV-2, spotlight, but novel threatening virus could appear anywhere at any time. Therefore, continued vigilance further warranted. We also note emphatically prevent future pandemics other world-wide health crises, imperative capitalize what have learnt from COVID-19: specifically, regarding its origins, world’s response, insufficient preparedness. This requires unprecedented international collaboration timely data sharing for coordination effective response rapid implementation containment measures.

Язык: Английский

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Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects

Rheumatology Science and Practice, Год журнала: 2024, Номер 62(1), С. 32 - 54

Опубликована: Фев. 29, 2024

The pandemic of coronavirus disease 2019 (COVID-19), etiologically related to the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus-2), has drawn attention new clinical and fundamental problems in immunopathology human diseases associated with virus-induced autoimmunity autoinflammation. provision that “the experience gained rheumatology process studying pathogenetic mechanisms pharmacotherapy immunoinflammatory rheumatic as most common severe forms autoimmune autoinflammatory pathology humans will be demand for deciphering nature pathological processes underlying COVID-19 developing approaches effective pharmacotherapy” was confirmed numerous studies conducted over next 3 years midst pandemic. main focus on a critical analysis data regarding role inflammation, which basis pathogenesis immune-mediated context COVID-19.

Язык: Английский

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Modern concept of autoimmunity in rheumatology

Rheumatology Science and Practice, Год журнала: 2023, Номер 61(4), С. 397 - 420

Опубликована: Авг. 31, 2023

Two fundamental pathologic processes are central to the spectrum of chronic inflammation mechanisms: autoimmunity and autoinflammation. Autoimmunity autoinflammation mutually potent processes; their development is considered within framework “immunoinflammatory” continuum, reflecting close relationship between innate acquired types immune response. leading mechanism pathogenesis a large group inflammatory human diseases, defined as autoimmune frequency which in population exceeds 10%. Advances molecular biology, pharmacogenetics bioinformatics have created prerequisites for individualization therapy rheumatic diseases concept personalized medicine. The study immunopathogenesis mechanisms, improvement diagnostics, deciphering nature taxonomy, approaches prevention among priority directions medicine 21st century.

Язык: Английский

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Effect of Diabetic Neuropathy on Reparative Ability and Immune Response System

Molecular Biotechnology, Год журнала: 2023, Номер unknown

Опубликована: Июль 31, 2023

The effects of diabetes can be divided into short, medium and long term various human organ systems effected. present study aimed to determine how much the duration mellitus (DM) affect reparative ability body, immune response development DM complications. Interleukin 1-β (IL-1β) 6 (IL-6) were monitored as specific indicators inflammatory reaction C-reactive protein (CRP), leukocyte count (WBC) sedimentation rate (ESR) general markers reaction. Tumour necrosis factor α (TNF-α) transforming growth β1 (TGF-β1) observed polyneuropathy. All interleukins determined by ELISA evaluated spectrophotometrically. Michigan Neuropathy Screening Instrument (MNSI) is performed for neuropathy examination. Patients with 3 groups, according mellitus. IL-6 levels correlated clinical stage diabetic polyneuropathy at p = 0.025 R 0.402; CRP 0.0001, 0.784 well correlation MNSI score (R 0.500, 0.034) in a group patients lasting up 10 years. body reduced physiological age ages duration. weakened additionally. dual activity cytokines TGF-β1 long-duration Diabetes Mellitus.

Язык: Английский

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Aspartame-induced cognitive dysfunction: Unveiling role of microglia-mediated neuroinflammation and molecular remediation

International Immunopharmacology, Год журнала: 2024, Номер 135, С. 112295 - 112295

Опубликована: Май 21, 2024

Язык: Английский

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Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19

Immunobiology, Год журнала: 2024, Номер 229(4), С. 152813 - 152813

Опубликована: Май 24, 2024

Post-COVID symptoms are reported in 10–35 % of patients not requiring hospitalization, and up to 80 hospitalized with severe disease. The pathogenesis post-COVID syndrome remains largely unknown. Some evidence suggests that prolonged inflammation has a key role the most manifestations. We evaluated panel inflammatory immune-mediated cytokines individuals altered HRCT features without any long-term COVID symptoms. Blood samples 89 adult previously COVID-19 were collected stratified as fibrotic lung alterations. Serum analyte concentrations IL-4, IL-2, CXCL10 (IP-10), IL-1β, TNF-α, CCL2 (MCP-1), IL-17A, IL-6, IL-10, IFN-γ, IL-12p70 TGF-β1 (free active form) quantified by bead-based multiplex assay. Clinical functional data recorded database. With use machine learning approach, IL-32, IL-8, IL-10 proved be associated development sequelae at follow-up. Direct comparison cytokine levels two groups showed increased IL-32 decreased IL-8 impairment. After further stratification severity (severe versus mild/moderate) during emerged only showing patients. These findings contribute better understanding immune response potential prognostic markers after COVID-19.

Язык: Английский

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Antibodies Specific to Rheumatologic and Neurologic Pathologies Found in Patient with Long COVID

Rheumato, Год журнала: 2025, Номер 5(1), С. 1 - 1

Опубликована: Янв. 20, 2025

The SARS-CoV-2 virus can cause hyperstimulation of the immune system, sometimes leading to production various autoantibodies and increased levels interferons interleukins in blood plasma. Background/Objectives: Only a few studies are currently focusing on dynamics immunological indices after any transferred infectious disease encountered by an organism for first time. attention researchers clinicians is captured antibody titers immunologic markers (interferons interleukins), as well correlation with changes symptomatology long COVID. This paper discusses association antibodies against autoantigens rheumatological neurological manifestations COVID-19. Our study patient was 36-year-old man diagnosed polyneuropathy, which developed We conducted dynamic follow-up two years. Methods: plasma samples collected were analyzed ELISA different autoantigens, IFN-γ, variety interleukins. Results: An between rheumatologic neurologic patients COVID symptoms considered. Antibody myelin basic protein (MBP), double-stranded DNA (dsDNA), single-stranded IL-1, IL-6, IL-10 significantly during posthospital period when reported persistent COVID, complaints decreasing resolved. Conclusions: findings this shed light alterations factors, elucidate mechanism infection disrupts immunotolerance eventually restores equilibrium, pathology. Significantly, notable rise transient did not lead progression autoimmune

Язык: Английский

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Strategic Inhibition of CHRM Autoantibodies: Molecular Insights and Therapeutic Potentials in Long COVID

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

In addition to the conventional symptoms reported for COVID-19, it is becoming increasingly clear that patients with long COVID are exhibiting new due emergence of autoantibodies against G-protein-coupled receptors, among which human muscarinic cholinergic receptors (CHRMs) have been prominently reported. With a chronic condition such as COVID, additional caused by anti-CHRM (AAbs) proven be an added burden on these patients. The origins AAbs, their interactions with, and effects function neural non-neural cells within nervous system remained unknown. Furthermore, specific symptom complex they contribute has not clearly understood. this context, we address issues here suggest methods combat neurological in COVID.

Язык: Английский

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TLR-5 influences T cell activity: implications for development of Type 1 Diabetes

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

In mammalian and human life, one of the most important problems is to choose best defence against microorganisms. Innate cells are good bacteria, T virus mainly because antibody production via helper B lymphocytes. Toll-like receptor 5 (TLR-5) a regulator this choice; when it highly expressed, inhibited, innate favored. activated pancreatic beta cells, TLR-5 has been found expressed may therefore be protected from cell destruction e.g., during pregnancy. We investigated mRNA islets Langerhans newly diagnosed T1D patients for TLR-5. Also, we examined polymorphisms between TLR-5, metabolic parameters, Type 1 Diabetes (T1D). was downregulated by one-third in compared controls. Regarding polymorphisms, two associations were monocytes which immune system. significant polymorphism seen concerning T1D. autoimmune diseases including present study find low values enhance cells. hope that findings mentioned article influential understanding how develops.

Язык: Английский

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