Chem & Bio Engineering,
Год журнала:
2024,
Номер
2(1), С. 3 - 22
Опубликована: Окт. 28, 2024
Extracellular
vesicles
(EVs)
are
secreted
from
biological
cells
and
contain
many
molecules
with
diagnostic
values
or
therapeutic
functions.
There
has
been
great
interest
in
academic
industrial
communities
to
utilize
EVs
as
tools
for
diagnosis
therapeutics.
In
addition,
can
also
serve
delivery
vehicles
molecules.
An
indicator
of
the
enormous
is
large
number
review
articles
published
on
EVs,
focus
ranging
their
biology
applications.
emerging
trend
EV
research
produce
"engineered
EVs",
which
essentially
enhanced
version
EVs.
engineering
be
conducted
by
cell
culture
condition
control,
genetic
engineering,
chemical
engineering.
Given
nanometer-scale
sizes
potentials,
engineered
an
class
nanomedicines.
So
far,
overwhelming
majority
preclinical
studies;
there
only
a
very
small
reported
clinical
trials.
This
Review
focuses
more
specific
being
applications
The
various
approaches
producing
diseases
reviewed.
Furthermore,
vivo
imaging
mechanistic
understandings,
translation
aspects
discussed.
discussion
primarily
studies
while
briefly
mentioning
With
continued
interdisciplinary
efforts
biologists,
pharmacists,
physicians,
bioengineers,
engineers,
could
become
powerful
solution
major
such
neurological,
immunological,
cardiovascular
diseases.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 225 - 225
Опубликована: Дек. 30, 2024
The
global
issue
of
aging
populations
has
become
increasingly
prominent,
thus
the
research
and
development
for
anti-aging
therapies
to
assure
longevity
as
well
ameliorate
age-related
complications
is
put
high
on
agenda.
young
humoral
milieu
been
substantiated
impart
youthful
characteristics
aged
cells
or
organs.
Extracellular
vesicles
(EVs)
are
a
heterogeneous
group
cell-derived
membrane-limited
structures
that
serve
couriers
proteins
genetic
material
regulate
intercellular
communication.
Of
note,
EVs
appeared
be
an
indispensable
component
blood
in
prolonging
lifespans,
circulating
have
indicated
mediate
beneficial
effect
aging.
Human
umbilical
cord
mesenchymal
stem
(HUCMSC-EVs),
isolated
from
youngest
adult
cell
source,
speculated
reproduce
function
partially
revitalize
numerous
organs
old
animals.
Robust
evidence
suggested
HUCMSC-EVs
muti-target
therapeutic
agents
combating
alleviating
degenerative
disorders.
Here,
we
provide
comprehensive
overview
effects
brain,
heart,
vasculature,
kidney,
muscle,
bone,
other
Furthermore,
critically
discuss
current
investigation
engineering
strategies
HUCMSC-EVs,
intending
unveil
their
full
potential
field
research.
Abstract
In
recent
years,
much
effort
has
been
devoted
to
designing
nanoparticle
drug
delivery
systems
and
improving
the
efficacy
of
anticancer
drugs.
This
study
focused
on
preparation
a
novel
biocompatible
nanocarrier
based
bacterial
cellulose
(BC)
in
presence
exosome
(Exo)
for
controlled
release
5‐fluorouracil
(5‐FU),
known
as
5‐FU.Exo@BC.
The
physicochemical
properties
5‐FU.Exo@BC
were
thoroughly
characterized
using
field
emission
scanning
electron
microscopy
(FESEM),
differential
calorimetry
(DSC),
Fourier‐transform
infrared
spectroscopy
(FTIR),
X‐ray
diffraction
(XRD).
These
results
confirmed
successful
behavior
compared
with
5‐FU
5‐FU@BC
demonstrated
significant
sustained
over
162
h.
mechanism
above
three
followed
Korsmeyer‐Peppas
non‐Fickian
diffusion
Furthermore,
viability
HT‐29
cells
(human
colon
cancer
cell
lines)
against
BC,
indicated
that
promising
system.
Subsequently,
prepared
bio‐nanocomposite
could
be
suggested
potential
system
an
effective
controlled‐release
function.
Chem & Bio Engineering,
Год журнала:
2024,
Номер
2(1), С. 3 - 22
Опубликована: Окт. 28, 2024
Extracellular
vesicles
(EVs)
are
secreted
from
biological
cells
and
contain
many
molecules
with
diagnostic
values
or
therapeutic
functions.
There
has
been
great
interest
in
academic
industrial
communities
to
utilize
EVs
as
tools
for
diagnosis
therapeutics.
In
addition,
can
also
serve
delivery
vehicles
molecules.
An
indicator
of
the
enormous
is
large
number
review
articles
published
on
EVs,
focus
ranging
their
biology
applications.
emerging
trend
EV
research
produce
"engineered
EVs",
which
essentially
enhanced
version
EVs.
engineering
be
conducted
by
cell
culture
condition
control,
genetic
engineering,
chemical
engineering.
Given
nanometer-scale
sizes
potentials,
engineered
an
class
nanomedicines.
So
far,
overwhelming
majority
preclinical
studies;
there
only
a
very
small
reported
clinical
trials.
This
Review
focuses
more
specific
being
applications
The
various
approaches
producing
diseases
reviewed.
Furthermore,
vivo
imaging
mechanistic
understandings,
translation
aspects
discussed.
discussion
primarily
studies
while
briefly
mentioning
With
continued
interdisciplinary
efforts
biologists,
pharmacists,
physicians,
bioengineers,
engineers,
could
become
powerful
solution
major
such
neurological,
immunological,
cardiovascular
diseases.
