COVID-19-Osteoarthritis Interactions, Predictions, and Mitigation: Can Blue Zone Findings Help? Overview and Commentary DOI Open Access
Ray Marks

Acta Scientific Pharmaceutical Sciences, Год журнала: 2023, Номер unknown, С. 26 - 36

Опубликована: Ноя. 1, 2023

The corona virus-19 , which unexpectedly heightened multiple health challenges among older adults beginning in December 2019, continues to influence many facets of elder including having a possible role exacerbating osteoarthritis linkages or combination 2023 and possibly beyond this period.At the same time, recent 2050 prevalence predictions that may well be underestimates imply any effort minimize disability must highly warranted its own right, because is major risk factor for severe COVID-19 infections.Based on key 2022-2023 data base posting, small body current work strengthens case our view more elucidation interpretation clinical significance presently alluded not overlook what has been learned about population wellbeing healthy aging from both pandemic as successes Blue Zone locations.

Язык: Английский

Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health DOI

Ahmet Alperen Palabiyik,

Esra Palabıyık

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

3
Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head DOI Creative Commons
Weihong Zhu, Zhenmu Xu,

Ding Zhou

и другие.

Journal of Tissue Engineering, Год журнала: 2025, Номер 16

Опубликована: Янв. 1, 2025

Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse at late stage, significantly impairing joint function. While MRI highly effective tool for diagnosing ONFH its early stages, challenges remain due to limited availability high cost MRI, as well absence routine screening asymptomatic patients. . In addition, current therapeutic strategies predominantly only relieve symptoms while disease-modifying drugs are still under investigation/development. Considering that supply plays key role pathology ONFH, angiogenic therapies have been put forward promising treatment options. Emerging bioengineering interventions targeting angiogenesis hold potential treatment. this review, we introduce advances research into summarize novel angiogenesis. review sheds light upon new directions future ONFH.

Язык: Английский

Процитировано

2
Research on Prediction of Multiple Degenerative Diseases and Biomarker Screening Based on DNA Methylation DOI Open Access
Run Tian, Hao Zhang, Chencai Wang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 313 - 313

Опубликована: Янв. 1, 2025

The aging process will lead to a gradual functional decline in the human body, and even accelerate significantly increased risk of degenerative diseases. DNA methylation patterns change markedly with one’s age, serving as biomarker biological age closely linked occurrence progression age-related Currently, diagnostic methods for individual diseases are relatively mature. However, often accompanies onset multiple diseases, presenting certain limitations existing models. Additionally, some identified biomarkers typically applicable only one or few types cancer further restricting their utility. We endeavor screen associated from perspective aging-related co-morbid mechanisms perform disease diagnoses. In this study, we explored research based on correlations investigate shared across identifying set them. validated these omics analysis prediction classes screened 600 110 by analysis, demonstrated validity predictive ability biomarkers. propose model multi-scale one-dimensional convolutional neural network (MSDCNN) multi-class (ResDegNet). two models well trained tested accurately diagnose categorize four providing foundation exploration conditions. This work aims facilitate early diagnosis, identification biomarkers, development therapeutic targets drug interventions.

Язык: Английский

Процитировано

1
Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer’s Disease Therapy DOI Open Access
Л. А. Васильева, Gulnara A. Gaynanova, Ф. Г. Валеева

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10494 - 10494

Опубликована: Июнь 22, 2023

Liposomes modified with tetradecyltriphenylphosphonium bromide dual loading of α-tocopherol and donepezil hydrochloride were successfully designed for intranasal administration. Physicochemical characteristics cationic liposomes such as the hydrodynamic diameter, zeta potential, polydispersity index within range from 105 to 115 nm, +10 +23 mV, 0.1 0.2, respectively. In vitro release curves analyzed using Korsmeyer-Peppas, Higuchi, First-Order, Zero-Order kinetic models. Nanocontainers surfactant statistically better penetrate into mitochondria rat motoneurons. Imaging brain slices revealed penetration nanocarriers brain. Experiments on transgenic mice an Alzheimer's disease model (APP/PS1) demonstrated that administration 21 days resulted in enhanced learning abilities a reduction formation rate Aβ plaques entorhinal cortex hippocampus

Язык: Английский

Процитировано

21
Mitochondria: fundamental characteristics, challenges, and impact on aging DOI

Runyu Liang,

Luwen Zhu,

Yongyin Huang

и другие.

Biogerontology, Год журнала: 2024, Номер 25(6), С. 923 - 941

Опубликована: Авг. 28, 2024

Язык: Английский

Процитировано

7
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases DOI Creative Commons
Yuchen He, Yishu Fan, Xenab Ahmadpoor

и другие.

Medicinal Research Reviews, Год журнала: 2024, Номер 44(6), С. 2472 - 2509

Опубликована: Май 6, 2024

Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded lysosomal functional scope revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, cellular stress response. Lysosomal dysfunction is also found be associated with aging several diseases. Therefore, function of macroautophagy, a lysosome-dependent intracellular degradation system, has been identified one updated twelve hallmarks aging. In this review, we begin by introducing concept quality control (LQC), which machinery that maintains number, morphology, through different processes such biogenesis, reformation, fission, fusion, turnover, lysophagy, exocytosis, permeabilization repair. Next, summarize results from studies reporting association between LQC dysregulation aging/various disorders. Subsequently, explore emerging therapeutic strategies target distinct aspects for treating diseases combatting Lastly, underscore existing knowledge gap propose potential avenues future research.

Язык: Английский

Процитировано

6
A Network Meta-Analysis of Different Psychological Therapies for Death Anxiety in Older Adults DOI
Jinhong Lu,

Youzhuan Yang,

Hongchao Ma

и другие.

OMEGA - Journal of Death and Dying, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Objective: The purpose of this research was to assess and contrast the impact psychosocial therapies on older individuals' death anxiety offer evidence-based recommendations both adults healthcare professionals. Methods: Randomized controlled trials (RCTs) were collected through a thorough search multiple databases such as PubMed, Embase, Cochrane Library, Web Science, Scopus, etc. Review Manager 5.4 employed evaluate caliber included studies, STATA (15.1) used for data analysis. Results: This study seven randomized with total 266 adults, time ranged from earliest possible date July 2024. results Network Meta-Analysis (NMA) showed that teaching components spiritual intelligence therapy significantly reduced in elderly (SUCRA: 99.6%). Conclusion: network ranking chart psychotherapeutic method, had most superior efficacy reducing elderly.

Язык: Английский

Процитировано

0
Mitochondrial DNA in atherosclerosis research progress: a mini review DOI Creative Commons
Zheng Liu, Nan Huang, Chan Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 7, 2025

Atherosclerosis (AS) is a chronic inflammatory disease that primarily affects large and medium-sized arteries one of the leading causes death worldwide. This article reviews multifaceted role mitochondrial DNA (mtDNA) in AS, including its structure, function, release, relationship with inflammation. Damage release mtDNA are considered central drivers development as they participate progression AS by activating pathways affecting lipid metabolism. Therefore, therapeutic strategies targeting downstream effects may provide new avenues to address this global health challenge.

Язык: Английский

Процитировано

0
The Effect of Hydrogen-Rich Water on Retinal Degeneration in the Outer Nuclear Layer of Simulated Weightlessness Rats DOI

Yuxue Mu,

Wenhao Li,

Dongyu Wei

и другие.

Life Sciences in Space Research, Год журнала: 2025, Номер 45, С. 158 - 169

Опубликована: Март 16, 2025

Язык: Английский

Процитировано

0
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence DOI Creative Commons

Zuzana Liblova,

Dominika Maurencova,

Barbora Šalovská

и другие.

Molecular Oncology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 27, 2025

Cellular senescence has recently been recognized as a significant contributor to the poor prognosis of glioblastoma, one most aggressive brain tumors. Consequently, effectively eliminating senescent glioblastoma cells could benefit patients. Human ADP/ATP translocases (ANTs) play role in oxidative phosphorylation both normal and tumor cells. Previous research shown that sensitivity mitochondria‐targeted senolytics depends on level ANT2. Here, we systematically mapped transcript protein levels ANT isoforms various types tumorigenesis. We employed bioinformatics analysis, targeted mass spectrometry, RT‐PCR, immunoblotting, assessment cellular energy state elucidate how individual are expressed during development noncancerous observed consistent elevation ANT1 across all tested types, while ANT2 ANT3 exhibited variable changes. Alterations isoform correlated with shifts oxygen consumption rate. Our findings suggest mutually interchangeable for manipulating have potential senolytic therapy.

Язык: Английский

Процитировано

0