Acta Scientific Pharmaceutical Sciences,
Год журнала:
2023,
Номер
unknown, С. 26 - 36
Опубликована: Ноя. 1, 2023
The
corona
virus-19
,
which
unexpectedly
heightened
multiple
health
challenges
among
older
adults
beginning
in
December
2019,
continues
to
influence
many
facets
of
elder
including
having
a
possible
role
exacerbating
osteoarthritis
linkages
or
combination
2023
and
possibly
beyond
this
period.At
the
same
time,
recent
2050
prevalence
predictions
that
may
well
be
underestimates
imply
any
effort
minimize
disability
must
highly
warranted
its
own
right,
because
is
major
risk
factor
for
severe
COVID-19
infections.Based
on
key
2022-2023
data
base
posting,
small
body
current
work
strengthens
case
our
view
more
elucidation
interpretation
clinical
significance
presently
alluded
not
overlook
what
has
been
learned
about
population
wellbeing
healthy
aging
from
both
pandemic
as
successes
Blue
Zone
locations.
Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 638 - 638
Опубликована: Апрель 29, 2025
Obesity
is
a
condition
of
chronic
low-grade
inflammation
affecting
peripheral
organs
the
body,
as
well
central
nervous
system.
The
adipose
tissue
dysfunction
occurring
under
conditions
obesity
key
factor
in
onset
and
progression
variety
diseases,
including
neurodegenerative
disorders.
Mitochondria,
organelles
production
cellular
energy,
play
an
important
role
this
dysfunction.
Numerous
studies
highlight
close
link
between
adipocyte
mitochondrial
dysfunction,
resulting
excessive
ROS
inflammation.
This
transmitted
systemically,
leading
to
metabolic
disorders
that
also
impact
system,
where
pro-inflammatory
cytokines
impair
functions
different
areas
brain,
diseases.
To
date,
several
bioactive
compounds
are
able
prevent
and/or
slow
down
neurogenerative
processes
by
acting
on
functions.
Among
these,
some
molecules
present
Mediterranean
diet,
such
polyphenols,
carotenoids,
omega-3
PUFAs,
exert
protective
action
due
their
antioxidant
anti-inflammatory
ability.
aim
review
provide
overview
involvement
development
diseases
Alzheimer’s
disease,
Parkinson’s
multiple
sclerosis,
emphasizing
played
mitochondria,
main
actors
cross-talk
The Journal of Prevention of Alzheimer s Disease,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Despite
recent
FDA
approval
of
anti-amyloid
antibodies
for
Alzheimer’s
Disease,
strategies
that
target
early
molecular
mechanisms
and
could
delay
or
change
the
disease
trajectory
are
still
needed.
Mitochondria
emerge
as
a
signaling
organelle
modulate
multiple
to
enhance
cellular
bioenergetics
promote
neuronal
survival.
Approaches
mitochondrial
function
healthy
aging
delaying
onset
age-related
diseases
such
Disease.
Some
these
have
been
recently
tested
in
clinical
trials.
Emerging
evidence
demonstrates
response
mild
energetic
stress,
mitochondria
orchestrate
robust
adaptive
stress
activating
neuroprotective
mechanism.
The
objective
this
review
is
highlight
development
mitochondria-targeting
therapeutics
neurodegenerative
diseases,
complex
I
inhibitors
particular.
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Июль 1, 2024
To
examine
the
prevalence
and
potential
risk
factors
of
multimorbidity
among
older
adult
in
China.
In
addition,
we
investigated
pattern
multimorbidity.
Exploration of Medicine,
Год журнала:
2023,
Номер
unknown, С. 822 - 838
Опубликована: Окт. 31, 2023
Progeroid
syndromes
are
characterized
by
clinical
signs
of
premature
ageing,
which
may
contain
several
diseases
such
as
Werner
syndrome,
Bloom
Rothmund-Thomson
Hutchinson-Gilford
progeria
and
Cockayne
syndrome.
These
disorders
also
exhibit
some
pathological
involvements
reminiscent
primary
mitochondrial
diseases.
Emerging
evidence
has
linked
mitochondria
even
to
physiological
ageing.
In
addition,
alterations
in
the
maintenance
pathway
have
been
deliberated
relevant
age-related
particular,
mitophagy
its
regulatory
might
be
key
process
for
homeostasis
mitochondria.
Therefore,
chronic
DNA
damage
and/or
activation
poly[adenosine
diphosphate
(ADP)-ribose]
polymerase
1
(PARP1)
could
a
threat
alterations.
The
PARP1
is
an
enzyme
responding
damage,
involved
mitophagy.
Interestingly,
reported
play
important
role
longevity
lifespan,
attracted
growing
attention
with
social
development.
This
review
provide
rationalized
overview
involvement
oxidative
stresses
genetically
defined
accelerated
progeroid
syndromes,
innovative
therapeutic
approaches.
Acta Scientific Pharmaceutical Sciences,
Год журнала:
2023,
Номер
unknown, С. 26 - 36
Опубликована: Ноя. 1, 2023
The
corona
virus-19
,
which
unexpectedly
heightened
multiple
health
challenges
among
older
adults
beginning
in
December
2019,
continues
to
influence
many
facets
of
elder
including
having
a
possible
role
exacerbating
osteoarthritis
linkages
or
combination
2023
and
possibly
beyond
this
period.At
the
same
time,
recent
2050
prevalence
predictions
that
may
well
be
underestimates
imply
any
effort
minimize
disability
must
highly
warranted
its
own
right,
because
is
major
risk
factor
for
severe
COVID-19
infections.Based
on
key
2022-2023
data
base
posting,
small
body
current
work
strengthens
case
our
view
more
elucidation
interpretation
clinical
significance
presently
alluded
not
overlook
what
has
been
learned
about
population
wellbeing
healthy
aging
from
both
pandemic
as
successes
Blue
Zone
locations.
