Chinese Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Sepsis-related
organ
dysfunction
is
associated
with
increased
morbidity
and
mortality.
Previous
studies
have
found
that
the
endothelium
plays
crucial
roles
in
maintaining
vascular
permeability
during
sepsis,
as
well
regulating
inflammation
thrombosis.
During
endothelial
cells
may
release
cytokines,
chemokines,
pro-coagulant
factors,
express
adhesion
molecules.
In
general,
responses
sepsis
typically
inhibit
bacterial
transmission
coordinate
leukocyte
recruitment
to
promote
clearance.
However,
excessive
or
prolonged
activation
can
lead
impaired
microcirculation,
tissue
hypoperfusion,
dysfunction.
Given
structural
functional
heterogeneity
of
different
organs,
there
are
potential
differences
by
type,
risk
damage
vary
accordingly.
This
article
reviews
response
observed
its
effects
on
function,
summarizes
current
progress
development
therapeutic
interventions
targeting
response,
discusses
future
research
directions
serve
a
reference
for
researchers
field.
Abstract
The
study
aimed
to
determine
the
CCl
4
-induced
liver
fibrosis
model
in
pinealectomized
rats
and
biochemically,
immunohistochemically,
histopathologically
investigate
therapeutic
effect
of
melatonin
on
fibrosis.
surgical
procedure
for
pinealectomy
was
performed
at
beginning
study,
sham
were
administered
dissolved
corn
oil
(1:1)
alone
every
other
day
induce
or
together
with
(10
mg/kg)
therapy
15
days.
Melatonin
is
an
essential
agent
offers
alternative
strategy
by
suppressing
inflammation,
oxidative
stress,
TGF-β1
signaling
pathway.
Treatment
ameliorated
restoring
hepatocellular
damage
reducing
plasma
AST,
ALT,
ALP
values.
increases
activity
SOD
CAT,
which
are
important
enzymes
antioxidant
defence,
raises
GSH
levels,
further
enhances
function.
Also,
reduced
hepatic
inflammation
(IL-6
IL-1β)
stress
indices.
Moreover,
histopathological
changes
immunohistochemical
expression
restored
following
supplementation
rats.
Our
shows
that
has
a
beneficial
protecting
induced
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7883 - 7883
Опубликована: Июль 18, 2024
Epinephrine
(EP)
is
a
very
important
chemical
transmitter
in
the
transmission
of
nerve
impulses
central
nervous
system
mammals.
Ascorbic
acid
(AA)
considered
to
be
most
extracellular
fluid
antioxidant
and
has
properties
cell.
In
this
study,
series
transition
metal-polyhistidine-carboxylated
multi-wall
carbon
nanotube
nanocomposites
were
synthesized,
their
simultaneous
catalytic
effects
on
epinephrine
ascorbic
investigated.
The
results
showed
that
based
iron
ions
had
highest
activity.
prepared
biosensor
expressed
high
selectivity
toward
EP
AA
with
LOD
values
0.1
μΜ
0.01
(EP),
sensitivity
4.18
μA
mM-1
range
0.001-5
mM
(AA),
50.98
0.2-100
μM
265.75
0.1-1.0
(EP).
Moreover,
it
good
stability,
repeatability
real
sample
detection.
This
work
reference
for
design
new
electrochemical
enzyme-free
biosensors
detection
biomarkers.
Journal of Food Biochemistry,
Год журнала:
2023,
Номер
2023, С. 1 - 11
Опубликована: Окт. 4, 2023
This
study
aimed
to
investigate
the
effects
of
ketogenic
diet
(KD),
intermittent
fasting
(IF),
and
their
combination
on
testicular
tissue
hormonal
changes
in
adult
male
rats.
Twenty-eight
rats
were
randomly
divided
into
four
groups:
control
(CD),
KD,
IF,
KD
combined
with
IF
(IF
+
KD).
Body
weights
recorded,
serum
estradiol
testosterone
levels
analyzed,
oxidative
stress
parameters
nitric
oxide
(NO)
assessed.
Furthermore,
histopathological
analysis
was
conducted.
notably
enhanced
body
testis
reduced
levels.
Additionally,
improved
status
by
decreasing
malondialdehyde
myeloperoxidase
increasing
glutathione,
catalase,
NO
tissue.
Histopathological
examination
showed
spermatogenesis
groups.
These
findings
suggest
may
enhance
fertility
via
hormonal,
oxidative,
histological
improvements.
Chinese Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Sepsis-related
organ
dysfunction
is
associated
with
increased
morbidity
and
mortality.
Previous
studies
have
found
that
the
endothelium
plays
crucial
roles
in
maintaining
vascular
permeability
during
sepsis,
as
well
regulating
inflammation
thrombosis.
During
endothelial
cells
may
release
cytokines,
chemokines,
pro-coagulant
factors,
express
adhesion
molecules.
In
general,
responses
sepsis
typically
inhibit
bacterial
transmission
coordinate
leukocyte
recruitment
to
promote
clearance.
However,
excessive
or
prolonged
activation
can
lead
impaired
microcirculation,
tissue
hypoperfusion,
dysfunction.
Given
structural
functional
heterogeneity
of
different
organs,
there
are
potential
differences
by
type,
risk
damage
vary
accordingly.
This
article
reviews
response
observed
its
effects
on
function,
summarizes
current
progress
development
therapeutic
interventions
targeting
response,
discusses
future
research
directions
serve
a
reference
for
researchers
field.
