Unveiling global research trends and hotspots on mitochondria in NAFLD from 2000 to 2023: A bibliometric analysis DOI Creative Commons
Jingqin Hu, Ze Chen,

Yibing Zhou

и другие.

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(3)

Опубликована: Март 1, 2024

Abstract Background Nonalcoholic fatty liver disease (NAFLD) has garnered significant attention in the past decade as a prevalent chronic condition. Despite growing body of evidence implicating mitochondria NAFLD development, comprehensive bibliometric analyses within this research domain are scarce. This study aims to provide thorough overview knowledge framework and key areas related context NAFLD, utilizing techniques. Methods A search publications on from 2000 2023 was conducted using Web Science Core Collection database. VOSviewers, CiteSpace, R package “bibliometrix” were employed for precise assessment literature. Results Examining 2530 articles 77 countries, primarily led by United States China, revealed consistent increase mitochondria's role NAFLD. Leading institutions include University Coimbra, Missouri, Chinese Academy Sciences, Fudan University, Shanghai Jiao Tong University. Notably, International Journal Molecular Sciences emerged most popular journal, Hepatology frequently cited. With contributions 14,543 authors, Michael Roden published highest number papers, A. J. Samyal cocited author. Key focus investigating mitochondrial mechanisms impacting developing therapeutic strategies targeting mitochondria. Emerging hotspots associated with keywords such “inflammation,” “mitochondrial dysfunction,” “autophagy,” “obesity,” “insulin resistance.” Conclusion study, first analysis, synthesizes trends advancements Insights derived analysis illuminate current frontiers emerging interest, providing valuable reference scholars dedicated studies.

Язык: Английский

Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health DOI

Ahmet Alperen Palabiyik,

Esra Palabıyık

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

3
Altered Mitochondrial Function in MASLD: Key Features and Promising Therapeutic Approaches DOI Creative Commons
Tatjana Radosavljević,

Milica Branković,

Janko Samardžić

и другие.

Antioxidants, Год журнала: 2024, Номер 13(8), С. 906 - 906

Опубликована: Июль 26, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty (NAFLD), encompasses a range of conditions from steatosis to steatohepatitis (NASH). Its prevalence, especially among patients with metabolic syndrome, highlights its growing global impact. The pathogenesis MASLD involves dysregulation, inflammation, oxidative stress, genetic factors and, notably, mitochondrial dysfunction. Recent studies underscore the critical role dysfunction in MASLD's progression. Therapeutically, enhancing function has gained interest, along lifestyle changes and pharmacological interventions targeting processes. FDA's approval resmetirom for metabolic-associated (MASH) fibrosis marks significant step. While represents progress, further research is essential understand MASLD-related fully. Innovative strategies like gene editing small-molecule modulators, alongside interventions, can potentially improve treatment. Drug repurposing new targets will advance therapy, addressing increasing burden. Therefore, this review aims provide better understanding identify more effective preventive treatment strategies.

Язык: Английский

Процитировано

14
The gut-liver axis: emerging mechanisms and therapeutic approaches for nonalcoholic fatty liver disease and type 2 diabetes mellitus DOI
Monika Bhardwaj, Papiya Mitra Mazumder

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 11, 2024

Язык: Английский

Процитировано

7
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy DOI Creative Commons

Pei Ye,

Hong Liu, Yao Qin

и другие.

Chemico-Biological Interactions, Год журнала: 2024, Номер 400, С. 111166 - 111166

Опубликована: Июль 27, 2024

Smoking is a well-established risk factor for several oral diseases, including cancer, leukoplakia and periodontitis, primarily related to reactive oxygen species (ROS). SS-31, mitochondria-targeting tetrapeptide, has exhibited demonstrable efficacy in medical conditions by attenuating mitochondrial ROS production. However, its potential the treatment of diseases remains underexplored. The aim this study was investigate therapeutic SS-31 mitigating smoking-induced epithelial injury. Through vitro experiments, our results indicate that plays protective role against cigarette smoke extract (CSE) reducing oxidative stress, inflammatory response, restoring function. Furthermore, we found mitophagy, regulated PINK1 (PTEN-induced putative kinase 1)/Parkin (Parkin RBR E3 ubiquitin-protein ligase), critical SS-31. Our findings offer valuable insights into SS-31's CSE-induced dysfunction cells. This provides novel intervention targets smoking-related diseases.

Язык: Английский

Процитировано

4
Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes DOI
Ming‐Ying Lu, Yu‐Ju Wei, Chih‐Wen Wang

и другие.

World Journal of Gastroenterology, Год журнала: 2025, Номер 31(10)

Опубликована: Фев. 26, 2025

BACKGROUND Insulin resistance, lipotoxicity, and mitochondrial dysfunction contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Mitochondrial impairs oxidative phosphorylation increases reactive oxygen species production, leading steatohepatitis hepatic fibrosis. Artificial intelligence (AI) is a potent tool for diagnosis risk stratification. AIM To investigate DNA polymorphisms in susceptibility MASLD establish an AI model screening. METHODS Multiplex polymerase chain reaction was performed comprehensively genotype 82 variants screening dataset (n = 264). The significant single nucleotide polymorphism validated independent cohort 1046) using Taqman® allelic discrimination assay. Random forest, eXtreme gradient boosting, Naive Bayes, logistic regression algorithms were employed construct MASLD. RESULTS In dataset, only mt12361A>G significantly associated with showed borderline significance patients 2-3 cardiometabolic traits compared controls validation (P 0.055). Multivariate analysis confirmed that factor [odds ratio (OR) 2.54, 95% confidence interval (CI): 1.19-5.43, P 0.016]. genetic effect non-diabetic group but not diabetic group. mt12361G carriers had 2.8-fold higher than A (OR 2.80, 95%CI: 1.22-6.41, 0.015). By integrating clinical features mt12361A>G, random forest outperformed other detecting [training area under receiver operating characteristic curve (AUROC) 1.000, AUROC 0.876]. CONCLUSION variant increased severity patients. supports management primary care settings.

Язык: Английский

Процитировано

0
LC-HRMS profiling of Dendrobium huoshanense aqueous extract and its therapeutic effects on nonalcoholic fatty liver disease in mice through the TLR2-NF-κB and AMPK-SREBP1-SIRT1 signaling pathways DOI
Qiyan Lin, Huang Ke, Xiyu Ge

и другие.

Journal of Chromatography B, Год журнала: 2025, Номер unknown, С. 124563 - 124563

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Effect of Different Fatty Acid Types on Mitochondrial Dysfunction Associated With Brown and Beige Adipose Tissue DOI
Yasmin Alaby Martins Ferreira, Débora Estadella, Luciana Pellegrini Pisani

и другие.

Nutrition Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Abstract Adipose tissue serves as a dynamic endocrine organ that is pivotal in metabolic regulation. Augmenting mitochondrial activity within this holds promise combating obesity. Mitochondrial function intricately modulated by diverse fatty acid compositions. This comprehensive review aimed to elucidate the molecular mechanisms underlying dysfunction induced various profiles. While saturated acids (SFAs) pose threat integrity, polyunsaturated (PUFAs), notably n-3, mitigate SFA-induced damage, concurrently regulating thermogenic gene expression. With regard monounsaturated (MUFAs), their impact on adipose remains relatively unexplored. Although human studies are imperative for insights, prioritizing consumption of n-3 and MUFAs has emerged strategic approach, potentially enhancing biogenesis pathways. synthesis underscores critical need further investigation differential effects types mitochondria, offering potential avenues obesity intervention.

Язык: Английский

Процитировано

0
Dimethyl Fumarate Improves Non-Alcoholic Fatty Liver Disease by Regulating SIRT1 Signal to Inhibit MAMs Over-Enrichment DOI
Rui Zhang, Quanwei Zhang,

Ziyi Cui

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177693 - 177693

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies DOI Creative Commons
Zhengfeng Xiong, Yuanpeng Liao, Z. Zhang

и другие.

Biomolecules, Год журнала: 2025, Номер 15(5), С. 670 - 670

Опубликована: Май 6, 2025

Cardiomyopathies comprise a heterogeneous group of cardiac disorders characterized by structural and functional abnormalities in the absence significant coronary artery disease, hypertension, valvular or congenital defects. Major subtypes include hypertrophic, dilated, arrhythmogenic, stress-induced cardiomyopathies. Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) production antioxidant defenses, has emerged as key contributor to pathogenesis these conditions. ROS-mediated injury drives inflammation, protease activation, mitochondrial dysfunction, cardiomyocyte damage, thereby promoting remodeling decline. Although numerous studies implicate OS cardiomyopathy progression, precise molecular mechanisms remain incompletely defined. This review provides updated synthesis current findings on OS-related signaling pathways across subtypes, emphasizing emerging therapeutic targets within redox-regulatory networks. A deeper understanding may guide development targeted strategies improve clinical outcomes affected patients.

Язык: Английский

Процитировано

0
Predicting mitophagy-related genes and unveiling liver endothelial cell heterogeneity in hepatic ischemia-reperfusion injury DOI Creative Commons

Bochen Pan,

Xuan Ma,

Shihuan Zhou

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 17, 2024

Hepatic Ischemia-Reperfusion Injury (HIRI) is a major complication in liver transplants and surgeries, significantly affecting postoperative outcomes. The role of mitophagy, essential for removing dysfunctional mitochondria maintaining cellular balance, remains unclear HIRI.

Язык: Английский

Процитировано

3