Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
Mitochondria
are
essential
double-membrane
organelles
with
intricate
structures
and
diverse
functions
within
cells.
Under
normal
physiological
conditions,
mitochondria
regulate
cellular
metabolism
maintain
energy
homeostasis
via
the
electron
transport
chain,
mediate
stem
cell
fate,
modulate
reactive
oxygen
species
production,
playing
a
pivotal
role
in
supply
lifespan
extension.
However,
mitochondrial
dysfunction
can
lead
to
various
pathological
changes,
including
aging,
necrosis,
dysregulated
tumor
immunity,
initiation
progression
of
cancer.
Moreover,
abnormal
is
closely
associated
numerous
diseases,
such
as
neurodegenerative
disorders,
metabolic
syndromes,
cancers.
In
recent
years,
targeting
has
emerged
promising
anticancer
strategy,
aiming
for
therapeutic
benefits.
Nonetheless,
approaches
face
limitations,
low
delivery
efficiency
insufficient
specificity.
This
review
systematically
explores
structure
function,
their
roles,
potential
challenges
mitochondria-targeted
strategies
cancer
therapy,
providing
insights
future
research
directions.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Май 21, 2024
A
century
ago,
the
Warburg
effect
was
first
proposed,
revealing
that
cancer
cells
predominantly
rely
on
glycolysis
during
process
of
tumorigenesis,
even
in
presence
abundant
oxygen,
shifting
main
pathway
energy
metabolism
from
tricarboxylic
acid
cycle
to
aerobic
glycolysis.
Recent
studies
have
unveiled
dynamic
transfer
mitochondria
within
tumor
microenvironment,
not
only
between
but
also
and
stromal
cells,
immune
others.
In
this
review,
we
explore
pathways
mechanisms
mitochondrial
as
well
how
these
activities
promote
aggressiveness,
chemotherapy
resistance,
evasion.
Further,
discuss
research
progress
potential
clinical
significance
targeting
phenomena.
We
highlight
therapeutic
intercellular
a
future
anti-cancer
strategy
enhancing
cell-mediated
immunotherapy.
Mycology: An International Journal on Fungal Biology,
Год журнала:
2024,
Номер
15(3), С. 345 - 359
Опубликована: Фев. 14, 2024
Generally,
Cryptococcus
initially
infects
the
respiratory
tract,
but
can
spread,
eventually
crossing
blood-brain
barrier
(BBB)
and
causing
meningitis
or
meningoencephalitis.
Specifically,
invades
vascular
endothelial
cells
of
BBB,
from
which
it
enters
brain.
The
main
mechanisms
through
crosses
BBB
are
transcellular
traversal,
paracellular
pathway,
via
Trojan
horse.
In
this
paper,
by
were
explained
in
detail.
addition
to
pathways
entry
brain,
paper
presents
a
discussion
on
some
rare
cryptococcal
infections
provides
insights
for
future
research
directions.
Cells,
Год журнала:
2024,
Номер
13(17), С. 1448 - 1448
Опубликована: Авг. 29, 2024
Exercise
can
promote
sustainable
protection
against
cold
and
warm
liver
ischemia-reperfusion
injury
(IRI)
tumor
metastases.
We
have
shown
that
this
is
by
the
induction
of
hepatic
mitochondrial
biogenesis
pathway.
In
study,
we
hypothesize
ZLN005,
a
PGC-1α
activator,
be
utilized
as
an
alternative
therapeutic
strategy.
Metabolites,
Год журнала:
2024,
Номер
14(4), С. 229 - 229
Опубликована: Апрель 17, 2024
The
cancer
paradigm
is
generally
based
on
the
somatic
mutation
model,
asserting
that
a
disease
of
genetic
origin.
mitochondrial–stem
cell
connection
(MSCC)
proposes
tumorigenesis
may
result
from
an
alteration
mitochondria,
specifically
chronic
oxidative
phosphorylation
(OxPhos)
insufficiency
in
stem
cells,
which
forms
cells
(CSCs)
and
leads
to
malignancy.
Reviewed
evidence
suggests
MSCC
could
provide
comprehensive
understanding
all
different
stages
cancer.
metabolism
altered
(OxPhos
insufficiency)
must
be
compensated
by
using
glycolysis
glutaminolysis
pathways,
are
essential
their
growth.
mitochondria
regulate
tumor
microenvironment,
also
necessary
for
evolution.
Therefore,
help
improve
our
tumorigenesis,
metastases,
efficiency
standard
treatments,
relapses.
