Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 17, 2024
Hypobaric
hypoxia
exposure
occurs
at
high
altitudes,
including
plateaus,
and
affects
normal
intestinal
function
microbiota
composition.
Exposure
induces
an
inflammatory
response
oxidative
stress
injury,
ultimately
disrupting
homeostasis
causing
barrier
damage.
Thus,
due
to
its
anti-inflammatory,
antioxidative,
microbiota-regulating
properties,
Bifidobacterium
longum
is
a
potentially
effective
probiotic
intervention
protect
the
during
low-pressure
on
plateaus.
However,
mechanism
of
action
not
fully
defined.
In
this
study,
we
investigate
by
which
B.
intervenes
in
damage
caused
plateau
hypoxia.
To
end,
vivo
model
established
exposing
rats
simulated
hypoxic
environment.
The
experimental
were
subsequently
supplemented
with
strain
(JBLC-141)
extracted
from
feces
healthy
adults
Bama,
Guangxi.
JBLC-141
mitigates
effects
rat
barrier.
This
achieved
activating
Kelch-like
ECH-associated
protein
1
(KEAP1)/nuclear
factor
erythroid
2-related
2
(NRF2)
pathway,
alleviating
hypoxia-induced
injury.
also
attenuates
upregulates
expression
tight
junction
proteins
claudin-1,
occludin,
zonula
occludens-1.
Furthermore,
it
reduces
permeability,
effectively
ameliorating
repairing
histological
induced
addition,
positively
regulates
microbiota,
increasing
relative
abundance
beneficial
bacteria
while
reducing
that
pathogenic
maintaining
flora
rats.
Research Journal of Pharmacy and Technology,
Год журнала:
2025,
Номер
unknown, С. 1394 - 1404
Опубликована: Март 27, 2025
This
scoping
review
aims
to
investigate
the
impact
of
Intermittent
Hypobaric
Hypoxia
(IHH)
Therapy
on
immune
expression
Hypoxia-Inducible
Factor-1
alpha
(HIF-1α)
and
Vascular
Endothelial
Growth
Factor
(VEGF)
in
context
osteogenesis
mandibular
bone.
Through
a
systematic
literature
search
PubMed,
Scopus,
Web
Science
databases,
this
assessed
evidence
linking
IHH
increased
HIF-1α
VEGF,
which
play
essential
roles
angiogenesis.
Several
studies
showed
that
exposure
significantly
contributed
stimulation
angiogenesis
bone,
as
seen
from
histological
radiographic
parameters
improvement.
The
conclusions
support
concept
can
facilitate
bone
through
mechanisms
involving
activation
VEGF.
ABSTRACT
This
study
investigated
alterations
in
hematological
parameters,
gut
microbiota
composition,
and
fecal
plasma
metabolic
profiles
among
high-altitude
residents
during
reoxygenation
periods
of
1
week,
month,
4
months
to
elucidate
the
effects
on
human
physiology
metabolism.
Exposure
high
altitudes
alters
intestinal
flora,
metabolites,
disrupting
their
balance.
Distinct
differences
amino
acid,
lipid,
energy,
immune,
cofactor,
vitamin
metabolism
pathways
were
detected
between
high-
low-altitude
populations,
with
a
partial
recovery
disparities
reoxygenation.
Although
exhibited
limited
adaptive
homeostasis
altitude
variations,
abundance
microbial
taxa
expression
levels
metabolites
initial
phase,
particularly
first
sensitive
reoxygenated
environment.
Through
16S
rRNA
gene
sequencing
bioinformatics
analysis,
operational
taxonomic
units
(OTUs)
annotated
at
genus
level,
revealing
that
genera
Barnesiella,
Parabacteroides,
Megasphaera
,
along
L-arginine,
S1P,
alpha-D-glucose,
emerged
as
potential
biomarkers
for
week
populations.
Notably,
marked
change
oxidative
stress
an
increase
antioxidant
capacity
observed
early
Tyrosine
metabolism,
which
is
jointly
regulated
by
microbiota,
plays
important
role
under
conditions
Additionally,
pyridoxine
hypoxanthine
Rothia
correlated
significantly
deacclimatization
syndrome
scores
IMPORTANCE
Our
research
focuses
prompt
activation
tyrosine
following
reoxygenation,
regulatory
mechanisms
employed
feces
modulate
this
process.
stages
specific
such
Parabacteroides
alongside
including
emerge
pivotal
players.
our
findings
reveal
distinct
profile
characterized
decrease
MCHC
increases
MCV
RDW-SD
temporal
window
crucial
juncture
metabolome.
Whereas
month
signified
phase
microbiome’s
adaptation
altered
environmental
conditions,
evidenced
alpha
diversity.
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32257 - e32257
Опубликована: Июнь 1, 2024
New
3-furan-1-thiophene-based
chalcones
were
synthesized,
characterized
and
pharmacologically
evaluated
as
antibacterial
anticancer
agents
against
two
bacterial
species;
Gram-positive
(Streptococcus
pyogenes)
Gram-negative
(Pseudomonas
aeruginosa).
All
tested
final
compounds
active
the
S.
pyogenes
P.
aeruginosa.
Especially
compound
AM4
showed
large
inhibition
zone
(27.13
23.30
mm),
respectively.
Using
DPPH
assay,
new
for
their
free
radical
scavenging
activity
found
to
reach
up
90
%,
accomplished
at
a
test
concentration
of
200
μg/mL.
Furthermore,
chalcone
derivatives
investigated
breast
cell
lines;
MCF-7
(cancerous)
MCF-10A
(non-cancerous).
Compound
potent
(IC50
=
19.354
μg/mL)
in
comparison
other
derivatives.
In
silico
study
was
achieved
using
PyRx
AutoDock
Vina
software
(0.8)
interaction
types
between
hits
binding
sites
targeted
proteins;
glucosamine-6-phosphate
synthase
tubulin,
target
drugs,
Based
on
molecular
docking
results
bind
pocket
respective
proteins,
which
support
vitro
results.
conclusion,
could
serve
discovery
novel
and/or
drugs.
Akdeniz Spor Bilimleri Dergisi,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
The
aim
of
this
study
was
to
examine
the
oxidant
and
antioxidant
levels
that
could
be
observed
during
a
single
unit
slalom
giant
trainings
routinely
practiced
by
alpine
skiers
measuring
Total
Oxidant
Capacity
(TOC)
Antioxidant
(TAC).
18
male
athletes,
aged
between
29
experienced
in
international
ski
competitions,
participated
voluntarily
study.
Initially,
body
weight,
height,
mass
index,
VO2max
values
volunteers
were
determined
as
required.
Next,
underwent
training,
lasted
2.5
hours
with
five
days
interval,
on
competition
slope
complies
standards.
Venous
blood
samples
collected
before
after
both
training
applied
so
TOC
TAC
found
out
accordingly.
While
no
significant
change
applied,
increase
detected
(p
Clinical Science,
Год журнала:
2024,
Номер
138(22), С. 1467 - 1480
Опубликована: Ноя. 1, 2024
Abstract
The
effect
of
high
altitude
(HA,
>2500
m)
can
trigger
a
maladaptive
response
in
unacclimatized
individuals,
leading
to
various
HA
illnesses
such
as
pulmonary
edema
(HAPE).
present
study
investigates
circulating
cell
free
(cf)
DNA,
minimally
invasive
biomarker
that
elicit
pro-inflammatory
response.
Our
earlier
observed
altered
cfDNA
fragment
patterns
HAPE
patients
and
the
significant
correlation
these
with
peripheral
oxygen
saturation
levels.
However,
unclear
release
mechanisms
circulation
limit
its
characterization
clinical
utility.
not
only
increase
levels
(27.03
±
1.37
ng/ml;
n
=
145)
compared
healthy
sojourners
(controls,
14.57
0.74
65)
highlanders
(HLs,
15.50
0.8
34)
but
also
assayed
known
death
markers
involved
at
HA.
found
significantly
elevated
apoptotic
marker,
annexin
A5,
secondary
necrosis
or
late
mobility
group
box
1,
patients.
In
addition,
we
higher
oxidative
DNA
damage
8-hydroxy-2′-deoxyguanosine,
controls,
suggestive
role
status
promoting
inflammatory
potential
fragments
their
plausible
manifesting
pathophysiology.
Extensive
vitro
future
assays
confirm
immunogenic
may
act
danger-associated
molecular
pattern
associate
cellular
stresses
HAPE.
Hypobaric
hypoxia
causes
oxidative
stress
and
inflammatory
responses
disrupts
the
gut
microbiome
metabolome.
In
this
study,
we
developed
a
synbiotic
fermented
whey
beverage,
combining
kefir
