Genel Tıp Dergisi,
Год журнала:
2024,
Номер
34(6), С. 893 - 902
Опубликована: Дек. 30, 2024
ABSTRACT
All
of
the
microorganisms
that
live
in
intestines
are
called
microbiota.
Metabolites
and
molecules
produced
by
microbiota
can
affect
nervous
system
help
regulate
how
brain
works.
Communication
between
gut
is
mediated
microbiota,
brain-gut
axis.
There
some
evidence
to
suggest
changes
may
be
associated
with
autism
spectrum
disorder
(ASD).
It
also
thought
have
an
impact
on
function.
Studies
show
there
altered
profile
individuals
ASD
compared
normal
population.
Individuals
different
communities
reduced
overall
diversity.
However,
whether
these
cause
or
result
from
has
not
yet
been
fully
established.
Research
into
causes
treatment
ASDs
continues,
this
area
research
promising
potential
contribute
development
new
approaches
for
future.
Abstract
Previous
studies
have
shown
a
bidirectional
communication
between
human
gut
microbiota
and
the
brain,
known
as
microbiota–gut–brain
axis
(MGBA).
The
MGBA
influences
host's
nervous
system
development,
emotional
regulation,
cognitive
function
through
neurotransmitters,
immune
modulation,
metabolic
pathways.
Factors
like
diet,
lifestyle,
genetics,
environment
shape
composition
together.
Most
research
explored
how
regulates
host
physiology
its
potential
in
preventing
treating
neurological
disorders.
However,
individual
heterogeneity
of
microbiota,
strains
playing
dominant
role
diseases,
interactions
these
microbial
metabolites
with
central/peripheral
systems
still
need
exploration.
This
review
summarizes
driving
neurodevelopmental
disorders
(autism
spectrum
disorder
attention
deficit/hyperactivity
disorder),
neurodegenerative
diseases
(Alzheimer's
Parkinson's
disease),
mood
(anxiety
depression)
recent
years
discusses
current
clinical
preclinical
microbe‐based
interventions,
including
dietary
intervention,
probiotics,
prebiotics,
fecal
transplantation.
It
also
puts
forward
insufficient
on
provides
framework
for
further
BioScience Trends,
Год журнала:
2024,
Номер
18(3), С. 233 - 249
Опубликована: Июнь 17, 2024
The
brain-gut
axis
intricately
links
gut
microbiota
(GM)
dysbiosis
to
the
development
or
worsening
of
autism
spectrum
disorder
(ASD).
However,
precise
GM
composition
in
ASD
and
effectiveness
probiotics
are
unclear.
To
address
this,
we
performed
a
thorough
meta-analysis
28
studies
spanning
PubMed,
PsycINFO,
Web
Science,
Scopus,
MEDLINE,
involving
1,256
children
with
1042
neurotypical
children,
up
February
2024.
Using
Revman
5.3,
analyzed
relative
abundance
8
phyla
64
genera.
While
individuals
did
not
exhibit
significant
differences
included
phyla,
they
exhibited
elevated
levels
Parabacteroides,
Anaerostipes,
Faecalibacterium,
Clostridium,
Dorea,
Phascolarctobacterium,
Lachnoclostridium,
Catenibacterium,
Collinsella
along
reduced
percentages
Barnesiella,
Odoribacter,
Paraprevotella,
Blautia,
Turicibacter,
Lachnospira,
Pseudomonas,
Parasutterella,
Haemophilus,
Bifidobacterium.
Notably,
discrepancies
Bifidobacterium
persisted
even
upon
systematic
exclusion
individual
studies.
Consequently,
demonstrates
an
imbalance,
potential
increases
decreases
both
beneficial
harmful
bacteria.
Therefore,
personalized
probiotic
interventions
tailored
specifics
imperative,
rather
than
one-size-fits-all
approach.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Март 12, 2025
Autism
Spectrum
Disorder
(ASD)
is
a
neurodevelopmental
disorder
characterized
by
difficulties
in
social
interaction
and
communication,
repetitive
stereotyped
behaviors,
restricted
interests,
sensory
abnormalities.
Its
etiology
influenced
both
genetic
environmental
factors,
with
no
definitive
cause
identified
specific
pharmacological
treatments
available,
posing
significant
burden
on
patients’
families
society.
In
recent
years,
research
has
discovered
that
gut
microbiota
dysbiosis
plays
crucial
role
the
pathogenesis
of
ASD.
The
can
influence
brain
function
behavior
through
gut-brain
axis
via
nervous
system,
immune
metabolic
pathways.
On
one
hand,
microbes
such
as
Clostridium
Prevotella
species
are
found
to
be
abnormal
ASD
patients,
their
products,
like
short-chain
fatty
acids,
serotonin,
GABA,
also
involved
pathological
process
other
patients
exhibit
system
dysfunction,
cells
related
cytokines
affecting
neural
activities
brain.
Currently,
intervention
methods
targeting
microbiota,
probiotics,
prebiotics,
fecal
transplantation,
have
shown
some
potential
improving
symptoms.
However,
more
studies
needed
explore
long-term
effects
optimal
treatment
protocols.
This
paper
reviews
mechanisms
interrelationships
among
discusses
challenges
future
directions
existing
research,
aiming
provide
new
insights
for
prevention
Metabolites,
Год журнала:
2025,
Номер
15(4), С. 213 - 213
Опубликована: Март 21, 2025
Background/Objectives:
Currently,
the
diagnosis
of
autism
spectrum
disorder
(ASD)
relies
on
behavioral
observations,
frequently
causing
delays
in
early
identification.
Prognostic
markers
are
essential
for
customizing
therapy
and
monitoring
progress.
However,
there
currently
no
recognized
biomarkers
ASD.
The
current
systematic
review
aims
to
analyze
studies
intestinal
metabolome
children
(both
autistic
non-autistic)
identify
potential
metabolites
diagnostic
prognostic
purposes.
Methods:
We
searched
Medline,
Scopus,
Embase,
Web
Science
relevant
publications.
Results:
identified
11
examining
gut
that
distinguished
between
non-autistic
children.
These
also
revealed
connections
metabolites,
developmental
scores,
symptoms.
substances
were
associated
with
metabolic
pathways
such
as
amino
acids,
vitamins,
lipids,
oxidative
stress,
glycans,
xenobiotics,
nucleotides.
Conclusions:
findings
suggest
changes
may
be
linked
causes
or
development
autism.
Although
these
observations
came
from
a
few
reports,
only
high-quality
included
this
review.
Further
research
is
confirm
biomarkers.
Genes,
Год журнала:
2024,
Номер
15(4), С. 431 - 431
Опубликована: Март 29, 2024
Many
investigations
have
evaluated
the
expression
of
noncoding
RNAs
(ncRNAs)
as
well
their
related
molecular
functions
and
biological
machineries
in
individuals
with
alcohol
dependence.
Alcohol
dependence
may
be
one
most
prevailing
psychological
disorders
globally,
its
pathogenesis
is
intricate
inadequately
comprehended.
There
substantial
evidence
indicating
significant
links
between
multiple
genetic
factors
development
In
particular,
critical
roles
ncRNAs
been
emphasized
pathology
mental
illnesses,
probably
including
comprehension
action
modification,
furthermore,
they
emerged
therapeutic
targets
for
a
variety
psychiatric
It
worth
mentioning
that
dysregulated
has
regularly
detected
An
in-depth
knowledge
m6A
modification
valuable
novel
treatment
against
general,
more
profound
understanding
practical
might
make
important
contributions
to
precise
diagnosis
and/or
actual
management
Here,
this
review,
we
mostly
focused
on
up-to-date
regarding
alterations
modifications
Then,
present
prospects
future
research
applications
concept
engram
system.
A
great
deal
of
studies
have
assessed
the
expression
noncoding
RNAs
(ncRNAs)
as
well
their
relevant
molecular
functions
and
biological
mechanisms
in
individuals
alcohol
dependence.
Alcohol
dependence
is
one
most
prevalent
neuropsychological
disorders
worldwide,
its
pathogenesis
intricate
inadequately
understood.
There
considerable
evidence
demonstrating
substantial
links
between
multiple
genetic
factors
development
Critical
roles
ncRNAs
been
emphasized
pathophysiology
mental
diseases
including
In
comprehension
action
modification,
they
emerged
therapeutic
targets
for
a
variety
psychiatric
illness
Worth
mentioning,
dysregulated
has
regularly
detected
An
in-depth
knowledge
m6A
modification
may
be
valuable
novel
treatment
against
general,
deeper
functional
make
significant
contributions
to
precise
diagnosis
and/or
actual
Here
this
review,
we
mostly
focused
on
up-to-date
regarding
alterations
modifications
dependence,
then,
presented
prospects
future
research
application
with
concept
engram-system.
Biomolecules,
Год журнала:
2024,
Номер
14(4), С. 437 - 437
Опубликована: Апрель 3, 2024
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
characterized
by
severe
deficits
in
social
communication
and
interaction,
repetitive
movements,
abnormal
focusing
on
objects,
or
activity
that
can
significantly
affect
the
quality
of
life
afflicted.
Neuronal
glial
cells
have
been
implicated.
It
has
genetic
component
but
also
be
triggered
environmental
factors
drugs.
For
example,
prenatal
exposure
to
valproic
acid
acetaminophen,
ingestion
propionic
acid,
increase
risk
ASD.
Recently,
epigenetic
influences
ASD
come
forefront
investigations
etiology,
prevention,
treatment
this
disorder.
Epigenetics
refers
DNA
modifications
alter
gene
expression
without
making
any
changes
sequence.
Although
an
increasing
number
pharmaceuticals
chemicals
are
being
implicated
etiology
ASD,
here,
we
specifically
focus
molecular
abovementioned
alterations
neuronal
their
potential
connection
We
conclude
better
understanding
these
phenomena
lead
more
effective
interventions
