Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma

Cancers, Год журнала: 2024, Номер 16(17), С. 2975 - 2975

Опубликована: Авг. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Язык: Английский

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Advancements in Metal and Metal Oxide Nanoparticles for Targeted Cancer Therapy and Imaging: Mechanisms, Applications, and Safety Concerns

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106622 - 106622

Опубликована: Янв. 1, 2025

Язык: Английский

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Composite Nanoarchitectonics of Electrospun Piezoelectric PVDF/AgNPs for Biomedical Applications, Including Breast Cancer Treatment

Materials, Год журнала: 2024, Номер 17(15), С. 3872 - 3872

Опубликована: Авг. 5, 2024

This study focused on preparing composite nanomats by incorporating silver nanoparticles (AgNPs) in polyvinylidene fluoride (PVDF) nanofibers through the electrospinning process. A short review of piezoelectric PVDF-related research is presented. PVDF known for its biocompatibility and properties. Since electrical signals biological tissues have been shown to be relevant therapeutic applications, influence addition AgNPs piezoelectricity studied, due ability increase signal, along with providing antibacterial The prepared samples were characterized scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy. In addition, activity composites was examined using a cytotoxicity assay an assessment activity. obtained results show that incorporation into further enhances (crystalline β-phase fraction), already improved process, compared solution-casted samples, but only AgNPs/PVDF concentration up 0.3%; led reduction. showed promising effect PVDF/AgNPs MDA-MB-231 breast cancer cell line, following non-toxicity displayed regard healthy MRC-5 line. against Pseudomonas aeruginosa Staphylococcus aureus, as result Ag content. anticancer activity, combined properties nanofibers, presents new possibilities smart, multifunctional materials treatment development.

Язык: Английский

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"Nanoparticle-Based Sensitizers in Prostate Cancer Treatment: Enhancing Radiotherapy Efficacy through Innovative Nanotechnology: Narrative review"

Applied Radiation and Isotopes, Год журнала: 2025, Номер 218, С. 111671 - 111671

Опубликована: Янв. 12, 2025

Язык: Английский

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Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 11, 2025

Язык: Английский

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Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities

Cancers, Год журнала: 2025, Номер 17(4), С. 701 - 701

Опубликована: Фев. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Язык: Английский

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Nanomedicine with simple structure for programmable heat-shock protein inhibition and sensitized synergistic therapy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161307 - 161307

Опубликована: Март 1, 2025

Язык: Английский

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Nano-Engineering for Precision Oncology Unraveling Molecular Mechanisms and Pioneering Revolutionary Cancer Therapies

Indus journal of bioscience research., Год журнала: 2025, Номер 3(3), С. 9 - 18

Опубликована: Март 14, 2025

With previously unheard-of improvements in cancer detection, therapy, and monitoring, nano-engineering has become a game-changer precision oncology. Researchers can create nanoscale drug delivery systems that maximize therapeutic efficacy reduce systemic toxicity by utilizing nanotechnology. an emphasis on targeted delivery, tumor microenvironment manipulation, nanocarrier-mediated immunotherapy, this study investigates the molecular processes underlying nano-engineered therapeutics. By increasing specificity lowering side effects, innovations including photothermal photodynamic biomimetic nanostructures, nanoparticle-based CRISPR gene editing are transforming treatment of cancer. Furthermore, real-time, non-invasive detection monitoring made possible liquid biopsy technologies nano-biosensors, allowing for early intervention individualized plans. A comprehensive approach to management is provided interaction nanotechnology oncology, which also makes it easier multipurpose nanoplatforms combine diagnosis (theranostics). Nano-engineering enormous promise overcome resistance, improve immune system engagement, enable precision-targeted treatments as oncology develops. To clinical translation, however, issues biocompatibility, large-scale production, regulatory permissions need be resolved. focus its role developing ground-breaking changing face focuses recent advances, present difficulties, potential future paths therapy.

Язык: Английский

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Gold Nanobiosensors: Pioneering Breakthroughs in Precision Breast Cancer Detection

European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер unknown, С. 100238 - 100238

Опубликована: Окт. 1, 2024

Язык: Английский

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Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 26, 2024

Angiogenesis is the formation of blood vessels from existing vasculature, which important in tumor growth where metastatic spread, cancer cells depends on an adequate supply oxygen and nutrients removal waste products. Targeting angiogenesis has emerged as a promising therapeutic strategy for treatment. This study presents synthesis evaluation novel Ag-CeO2-ZnO (AgCZ) nanocomposite designed to specifically inhibit effective therapy. The was synthesized via glycine-assisted combustion method, its physicochemical properties were meticulously characterized using advanced analytical techniques. anti-angiogenesis potential AgCZ vigorously explored through assortment vitro investigations, with particular interest inhibiting agents like vascular endothelial factor (VEGF). In silico data molecular docking studies instrumental elucidating nanocomposite's primary reported mechanism action, i.e., strong VEGF target bond. Notably, had selective cytotoxicity different types no sign serious influence onto normal cells, reflecting great promise targeted Not importantly, implemented measure anti-angiogenic well anti-tumor effect biological models additionally. Our highlights emerging developments medicine draws possible future paths. use composite nanoparticle one anticancer drug alternative conventional appears be safer more effectual, but further research needed overcome current limitations clinical translation.

Язык: Английский

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