Illuminating new possibilities: Effects of copper oxide nanoparticles on gastrointestinal adenocarcinoma cells in hypoxic condition

Heliyon, Год журнала: 2024, Номер 10(10), С. e31414 - e31414

Опубликована: Май 1, 2024

Cancer remains a major global health concern, necessitating the development of novel therapeutic approaches. Hypoxia is common characteristic solid tumors that plays critical role in tumor progression, making it prime target for anticancer therapies. This study aimed to determine effects copper oxide nanoparticles (CuONPs) on human gastrointestinal cancer cells hypoxic condition first time. Toxicity CuONPs was evaluated colon and gastric adenocarcinoma normal fibroblasts by alamarBlue assay. Real-time polymerase chain reaction (PCR) performed genes involved cell apoptosis. To elucidate molecular mechanisms underlying condition, docking conducted HIF-1α. Results revealed dose- cell-type-dependent toxic CuONPs, as more significant (

Язык: Английский

Proangiogenic potential of plasma exosomes from prostate cancer patients

Cellular Signalling, Год журнала: 2024, Номер 124, С. 111398 - 111398

Опубликована: Сен. 13, 2024

Язык: Английский