Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2848 - 2848
Опубликована: Дек. 14, 2024
Background/Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
characterized
by
the
accumulation
of
triglycerides
within
hepatocytes,
which
can
progress
to
more
severe
conditions,
such
as
metabolic
steatohepatitis
(MASH),
may
include
progressive
fibrosis,
leading
cirrhosis,
cancer,
and
death.
This
goal
this
review
highlight
recent
research
showing
potential
mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
in
reducing
key
pathogenic
pathways
MASLD
or
MASH.
Methods:
Relevant
published
studies
were
identified
using
PubMed
with
one
following
search
terms:
MASLD,
MASH,
NAFLD,
NASH,
exosome,
vesicle
(EV),
therapy,
and/or
cells
(MSC).
The
primary
literature
subsequently
downloaded
summarized.
Results:
Using
vitro
vivo
models,
MSC-EVs
have
been
found
counteract
oxidative
stress,
a
significant
contributor
injury
suppress
progression,
including
steatosis,
inflammation,
and,
few
instances,
fibrosis.
Some
these
outcomes
attributed
specific
EV
cargo
components
microRNAs
proteins.
Thus,
enriched
types
molecules
improved
therapeutic
efficacy
for
MASLD/MASH
represent
novel
approach
potentially
halt
reverse
process.
Conclusions:
are
attractive
agents
treating
MASLD/MASH.
Further
necessary
validate
clinical
applicability
human
MASH
patients,
focusing
on
optimizing
delivery
strategies
identifying
that
targeted
components.
ACS Omega,
Год журнала:
2025,
Номер
10(1), С. 1207 - 1225
Опубликована: Янв. 3, 2025
Manufacturing
bioactive
materials
for
drug
delivery
involves
developing
that
interact
with
biological
tissues
to
release
drugs
in
a
controlled
and
targeted
manner.
The
goal
is
optimize
therapeutic
efficacy
reduce
side
effects
by
combining
knowledge
from
engineering,
biology,
pharmacology.
This
study
presents
detailed
bibliometric
analysis,
exploring
the
keywords
"manufacturing,"
"bioactive
materials,"
"drug
delivery"
identify
highlight
significant
advancements
field.
From
Web
of
Science,
36,504
articles
were
analyzed,
171
selected
deeper
identifying
key
journals,
countries,
institutions,
authors.
results
field's
interdisciplinary
nature,
grouped
into
four
main
themes,
including
regenerative
medicine,
scaffolds,
three-dimensional
(3D)
printing,
glass,
tissue
engineering.
Future
research
this
area
will
focus
on
more
effective
precise
systems
using
technologies
like
3D
printing
nanotechnology
enhance
customization
control
release,
aiming
efficient
therapies.
Brain Research Bulletin,
Год журнала:
2025,
Номер
unknown, С. 111219 - 111219
Опубликована: Янв. 1, 2025
Ischemic
stroke
(IS)
remains
a
significant
global
health
burden,
necessitating
the
development
of
novel
therapeutic
strategies.
This
study
aims
to
systematically
evaluate
effects
mesenchymal
stem
cell-derived
exosomes
(MSC-Exos)
on
IS
outcomes
in
rodent
models.
A
comprehensive
literature
search
was
conducted
across
multiple
databases
identify
studies
investigating
MSC-Exos
models
IS.
Following
rigorous
inclusion
and
exclusion
criteria,
73
high-quality
were
selected
for
meta-analysis.
Primary
included
reductions
infarct
volume/ratio
improvements
functional
recovery
scores.
Data
extraction
analysis
performed
using
RevMan
5.3
software.
Pooled
data
indicated
that
administration
significantly
reduced
size
improved
scores
Treatment
within
24hours
beyond
induction
both
demonstrated
substantial
compared
controls.
Furthermore,
MSC-Exos-treated
groups
exhibited
marked
recovery,
as
assessed
by
various
neurobehavioral
tests.
The
meta-analysis
showed
no
publication
bias,
heterogeneity
levels
acceptable.
reveal
potential
IS,
with
evidence
supporting
their
efficacy
reducing
enhancing
preclinical
These
findings
pave
way
further
research
clinical
translation.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 21, 2025
Abstract
Small
extracellular
vesicles
(sEVs)
play
a
critical
role
in
the
progression,
diagnosis,
and
treatment
of
prostate
cancer
(PCa),
particularly
within
tumor
microenvironment
(TME).
Acting
as
novel
biomarkers
agents
for
targeted
biological
therapy,
sEVs
contribute
significantly
to
improving
patient
survival.
These
transport
variety
biomolecules,
including
proteins,
nucleic
acids,
lipids,
which
are
instrumental
remodeling
TME,
facilitating
intercellular
communication,
influencing
key
processes
such
growth,
metastasis,
therapy
resistance.
A
thorough
understanding
sEV
heterogeneity,
their
biogenesis,
characteristics,
potential
applications,
is
essential.
Recent
advances
have
illuminated
origins,
formation
processes,
molecular
cargo
PCa-derived
(PCa-sEVs),
enhancing
our
disease
progression.
Furthermore,
show
promise
diagnostic
markers,
with
applications
early
detection
prognostic
assessment
PCa.
Therapeutically,
natural
engineered
offer
versatile
drug
delivery,
gene
immunomodulation,
underscoring
PCa
management.
This
review
delves
into
substantial
clinical
practices
Graphical
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 9, 2025
Mental
disorders
are
complex
conditions
that
encompass
various
symptoms
and
types,
affecting
approximately
1
in
8
people
globally.
They
place
a
significant
burden
on
both
families
society
as
whole.
So
far,
the
etiology
of
mental
remains
poorly
understood,
making
diagnosis
treatment
particularly
challenging.
Extracellular
vesicles
(EVs)
nanoscale
particles
produced
by
cells
released
into
extracellular
space.
contain
bioactive
molecules
including
nucleotides,
proteins,
lipids,
metabolites,
which
can
mediate
intercellular
communication
involved
physiological
pathological
processes.
Recent
studies
have
shown
EVs
closely
linked
to
like
schizophrenia,
major
depressive
disorder,
bipolar
playing
key
role
their
development,
diagnosis,
prognosis,
treatment.
Therefore,
based
recent
research
findings,
this
paper
aims
describe
roles
summarize
potential
applications
treatment,
providing
new
ideas
for
future
clinical
transformation
application
EVs.
