Digestive and Liver Disease, Год журнала: 2024, Номер 56(12), С. 2170 - 2171
Опубликована: Авг. 14, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июль 25, 2024
Long noncoding RNAs (lncRNAs) constitute a distinctive subset of RNA molecules with limited protein-coding potential, which exert crucial impacts on various biological activities. In the context cancer, dysregulated lncRNAs function as essential regulators that affect tumor initiation and malignant progression. These serve competitive endogenous (ceRNAs) through sponging microRNAs regulating expression targeted genes. Moreover, they also directly bind to RNA-binding proteins, can be integrated into complex mechanistic network. E2F1, an extensively studied transcription factor, mediates multiple behaviors by cell cycle progression, metastasis, therapeutic response. Emerging evidence suggests play pivotal role in E2F1 pathway. This review aims elucidate intricate gene regulatory programs between cancer We elaborate distinct networks involved emphasizing potential lncRNAs/E2F1 axes promising targets for therapy. Additionally, we provide novel perspectives current evidence, limitations, future directions targeting human cancers. Fully deciphering network lncRNA/E2F1-mediated mechanisms could facilitate translation findings clinical course, such efforts ultimately significantly improve prognosis patients.
Язык: Английский
Процитировано
3
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Апрель 1, 2025
Gastric cancer (GC) is an exceedingly aggressive disease and ranks as the third leading cause of cancer-related deaths, which poses a huge health burden globally. Chemotherapy commonly employed during middle to advanced stages cancer, although it faces frequent treatment failures attributed drug resistance. Thus, imperative for researchers identify potential targets overcoming therapeutic resistance, thereby facilitating development novel anti-cancer agents GC patients with stages. Long noncoding RNAs (lncRNAs) are diverse group transcripts limited protein-coding capacity, have been recognized functional molecules regulating progression including cell proliferation, metastasis, resistance in GC. In this review, we examine intricate molecular networks on role lncRNAs LncRNAs conferred through various mechanisms, therefore functioning promising patients. Additionally, discuss current advancements strategies targeting therapy, may pave way lncRNA-mediated precision medicine malignant disease.
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Июль 3, 2024
Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.
Язык: Английский
Процитировано
2
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Авг. 14, 2024
Cholangiocarcinoma (CCA) is a rare type of digestive tract cancer originating from the epithelial cells liver and biliary tract. Current treatment modalities for CCA, such as chemotherapy radiation therapy, have demonstrated limited efficacy in enhancing survival rates. Despite revolutionary potential immunotherapy management, its application CCA remains restricted due to minimal infiltration immune these tumors, rendering them cold unresponsive checkpoint inhibitors (ICIs). Cancer within tumors deploy various mechanisms evading attack, thus impeding clinical management. Recently, combination has become increasingly essential comprehend underlying enhance deficient antitumor response. Therefore, thorough understanding knowledge on imperative leverage benefits treating patients. Moreover, gut microbiota plays an role immunotherapeutic responses CCA. In this review, we summarize current concepts clarify intricate dynamics tumor microenvironment (TIME) We also delve into evasion employed by against anti-tumor responses. The context immunotherapies igniting critical function prompting been annotated. Furthermore, proposed future directions realm immunotherapy, aiming improve prognosis
Язык: Английский
Процитировано
2
Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155564 - 155564
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
2
Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(7)
Опубликована: Июль 13, 2024
Abstract Purpose Long noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate interactions with RNAs. Among these, lncRNA ZFAS1 has been implicated in oncogenic roles multiple cancer types. Nevertheless, the biological significance and underlying mechanism of initiation progression hepatocellular carcinoma (HCC) remain largely unexplored. Methods Analysis The Cancer Genome Atlas Program (TCGA) database revealed notable upregulation HCC tissues. To explore its function, we investigated colony formation performed CCK-8 assays to gauge cellular proliferation wound healing, Transwell assess migration, an vivo study employing nude mouse model scrutinize tumor growth metastasis. Luciferase reporter assay was used confirm interactions. Rescue experiments were conducted unravel plausible activation PI3K/AKT pathway by lncRNAs ATIC. Results ATIC significantly upregulated tissues cells. knockdown inhibited cell migration. We observed direct interaction between also suppressed SC79, activator AKT, partially restores effects ZFAS1/ATIC Knockdown lung metastasis vivo. Conclusion Overall, regulates transcription contributes migration cells signaling pathway.
Язык: Английский
Процитировано
1
Translational Cancer Research, Год журнала: 2024, Номер 13(10), С. 5347 - 5364
Опубликована: Окт. 1, 2024
Colorectal cancer (CRC) is one of the most common malignant tumors in digestive system with a high incidence, poor prognosis and an unsatisfactory therapeutic effect. Long non-coding RNAs (lncRNAs) play crucial roles various biological processes related to tumor progression. Immune-related lncRNA gene
Язык: Английский
Процитировано
1
Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(7)
Опубликована: Июль 20, 2024
Abstract Background Patients with autoimmune diseases (AD) generally carry an increased risk of developing cancer. However, the effect AD in hepatocellular carcinoma (HCC) patients receiving surgical treatment is uncertain. The present study aimed to investigate potential influence on survival HCC undergoing hepatectomies. Methods Operated were identified from Chang Gung Research Database, and outcomes or without analyzed ad compared. Cox regression model was performed identify significant factors associated disease recurrence mortality. Results From 2002 2018, a total 5532 underwent hepatectomy for their HCC. Among them, 229 have 5303 not. After excluding cases who died within 30 days surgery, estimated median overall (OS) 43.8 months (+) group 47.4 (–) ( P = 0.367). liver-specific disease-free (DFS) also comparable between two groups. multivariate analysis, presence did not lead higher all-cause mortality, recurrence. Conclusion Our demonstrated that does impair OS DFS liver resections. itself factor tumor after surgery. eligible resections, as result, should be considered surgery irrespective AD. Further studies are mandatory validate our findings.
Язык: Английский
Процитировано
0
Digestive and Liver Disease, Год журнала: 2024, Номер 56(12), С. 2170 - 2171
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
0