Inflammation Research, Год журнала: 2025, Номер 74(1)
Опубликована: Апрель 24, 2025
Язык: Английский
Cytokine, Год журнала: 2025, Номер 189, С. 156896 - 156896
Опубликована: Фев. 27, 2025
The characterization of physiological immune signatures in a population-based cohort is prerequisite for identifying pathological associated with inflammatory or autoimmune diseases. Here, 47 plasma cytokines, chemokines, and growth factors were quantified bead-based multiplex-assay (Merck HCYTA-60 K) using FLEXMAP 3D™ instrument 1175 individuals the Study Health Pomerania (SHIP; TREND cohort, 532 men 643 women, age: 20 to 81, BMI: 17.7 53.6). Associations cytokine concentrations age, sex, BMI, season, blood cell parameters (BCP) examined by multivariate regression models. differed strongly between analytes, median ranging from 0.6 7820 pg/mL. Many levels showed large dynamic range within study population. Higher pro-inflammatory cytokines chemokines IL-6, IL-8, CXCL9, CXCL10, IL-12p40, CCL2, CCL4, CCL11, IL-27, FLT3LG, TNFα significantly increasing age. strongest age-associated effects seen CXCL9 (βst = 0.4, p < 0.001) CXLC10 0.3, 0.001). Significant sex differences detected CCL3, CCL22, IL-1RA, IL-18, among which CCL11 effect -0.24, lower level women compared men. Moreover, seven i.e. TNFα, displayed higher BMI. Among those, was IL-1RA 0.19, 0.001), CCL4 0.16, CXCL10 0.14, Only -0.17, decreased Subjects categorized as obese exhibited elevated while only reduced normal weight. Certain such significance after adjustment components indicating (BCPs) potential confounders. We observed no significant non-linear seasonal investigated cytokines. generated atlas provides detailed information on variations general population will provide reference base disease-related studies future. Furthermore, BCPs should be considered confounders association based levels.
Язык: Английский
Процитировано
0
Inflammation Research, Год журнала: 2025, Номер 74(1)
Опубликована: Апрель 24, 2025
Язык: Английский
Процитировано
0