Endothelial Cell‐Derived Extracellular Vesicles Promote Aberrant Neutrophil Trafficking and Subsequent Remote Lung Injury
Advanced Science,
Год журнала:
2024,
Номер
11(38)
Опубликована: Авг. 9, 2024
The
development
of
acute
respiratory
distress
syndrome
(ARDS)
in
sepsis
is
associated
with
substantial
morbidity
and
mortality.
However,
the
molecular
pathogenesis
underlying
sepsis-induced
ARDS
remains
elusive.
Neutrophil
heterogeneity
dysfunction
contribute
to
uncontrolled
inflammation
patients
ARDS.
A
specific
subset
neutrophils
undergoing
reverse
transendothelial
migration
(rTEM),
which
characterized
by
an
activated
phenotype,
implicated
systemic
dissemination
inflammation.
Using
single-cell
RNA
sequencing
(scRNA-seq),
it
identified
functionally
exhibiting
rTEM
phenotype
lung
a
mouse
model
using
cecal
ligation
puncture.
prevalence
elevated
blood
sepsis-associated
positively
correlated
disease
severity.
Mechanically,
scRNA-seq
proteomic
analys
revealed
that
inflamed
endothelial
cell
(EC)
released
extracellular
vesicles
(EVs)
enriched
karyopherin
subunit
beta-1
(KPNB1),
promoting
abluminal-to-luminal
neutrophil
rTEM.
Additionally,
EC-derived
EVs
are
proportion
clinical
sepsis.
Collectively,
EV
as
critical
regulator
rTEM,
providing
insights
into
contribution
injury.
Язык: Английский
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
NeuroMolecular Medicine,
Год журнала:
2024,
Номер
26(1)
Опубликована: Сен. 15, 2024
Язык: Английский
Prevalence of Early Seizures in Acute Stroke Patients
Zishan Akhter Wali,
Najam Azam,
Hasan Farooq
и другие.
Pakistan Journal of Health Sciences,
Год журнала:
2024,
Номер
unknown, С. 194 - 197
Опубликована: Сен. 30, 2024
A
stroke
is
defined
as
a
sudden
neurological
deficit
of
cerebrovascular
cause
that
persists
beyond
24
hours.
Stroke
associated
with
whole
spectrum
complications,
especially
post-stroke
seizures.
These
seizures
may
adversely
affect
the
outcome
in
terms
mortality
and
morbidity.
This
study
was
designed
to
find
out
frequency
early
Objective:
To
determine
early-onset
after
among
patients
presenting
tertiary
care
hospitals.
Methods:
Two
hundred
forty
patients,
on
Medical
floor
Jinnah
Hospital
Lahore
acute
fulfilling
selection
criteria,
were
approached
informed
consent.
The
followed
for
14
days
development
stroke.
Results:
Among
240
there
123
(51.3%)
male
117
(48.8%)
female
patients.
minimum
age
observed
30
years
maximum
noted
77
years.
In
45%
hemorrhagic
detected
55%
had
ischemic
From
108
cases
stroke,
10.4%
which
an
episode
seizure
occurred
within
On
other
hand,
132
15.9%
developed
episodes.
Conclusions:
It
concluded
more
common
than
our
population
occurrence
prevalent
Язык: Английский