Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: focus on PPARs, LXRs, and PCSK9 DOI Creative Commons
Marcella Palumbo, M. Ugolotti, Francesca Zimetti

и другие.

Atherosclerosis Plus, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

A large body of evidence has shown that modulation the nuclear receptors peroxisome proliferator-activated (PPARs), liver X (LXRs), proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammatory processes by natural compounds hypolipidemic anti-atherosclerotic effects. These beneficial outcomes are certainly related to crucial function these targets in maintaining cholesterol homeostasis regulating systemic inflammation. Currently, therapeutic scenario for cardiovascular diseases (CVD) offers a plethora widely validated functional pharmacological treatments improve health status patients. However, patients increasingly sceptical which often associated with moderate severe side The aim our review is provide collection most recent scientific on common phytochemicals, used centuries Mediterranean diet traditional chinese medicine act key regulators inflammation, could constitute important tools CVD management.

Язык: Английский

Research Progress on Anti-Hyperlipidemia Peptides Derived from Foods DOI Open Access

Mingxia Zhao,

Kaina Qiao,

Lili Zhang

и другие.

Nutrients, Год журнала: 2025, Номер 17(7), С. 1181 - 1181

Опубликована: Март 28, 2025

Hyperlipidemia is a metabolic disorder in which cholesterol (TC) and triglycerides (TGs) the blood exceed normal physiological levels. The incidence of condition has continued to rise recent years, posing serious threat public health. Its clinical treatment mainly relies on drug interventions, such as statins, fibrate, niacin. Although these drugs have shown some efficacy hyperlipidemia, their adverse effects cannot be ignored. In contrast, naturally derived peptides gradually become potential candidates for prevention hyperlipidemia due strong anti-hyperlipidemic activity safety; examples include those from dairy products, grains, legumes, seafood. This review systematically summarizes with analyzes mechanisms action, providing theoretical basis further research. addition, we also outline challenges facing application peptides, hoping prevent reduce its by encouraging consumption foods rich anti-hyperlipidemia peptides.

Язык: Английский

Процитировано

0

Lipid-lowering efficacy of obicetrapib: A comprehensive systematic review and meta-analysis. DOI
Walter Massón,

Leandro Barbagelata,

Martín Lobo

и другие.

Journal of clinical lipidology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1

Metabolic Effects of Loquat Juice (Eriobotrya japonica Lindl Mkarkeb Variety) on Lipid Homeostasis, Liver Steatosis, and Oxidative Stress in Hyperlipidemic Mice Fed a High-Fat–High-Fructose Diet DOI Creative Commons
Imane Mokhtari, Thamer Aljutaily, Huda Aljumayi

и другие.

Metabolites, Год журнала: 2024, Номер 14(11), С. 592 - 592

Опубликована: Ноя. 2, 2024

Loquat fruit is consumed for its flavorful taste and a rich array of health-promoting compounds like phenolics, flavonoids, carotenoids. This study aimed at the biochemical characterization fresh juice from Moroccan

Язык: Английский

Процитировано

0

Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: focus on PPARs, LXRs, and PCSK9 DOI Creative Commons
Marcella Palumbo, M. Ugolotti, Francesca Zimetti

и другие.

Atherosclerosis Plus, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

A large body of evidence has shown that modulation the nuclear receptors peroxisome proliferator-activated (PPARs), liver X (LXRs), proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammatory processes by natural compounds hypolipidemic anti-atherosclerotic effects. These beneficial outcomes are certainly related to crucial function these targets in maintaining cholesterol homeostasis regulating systemic inflammation. Currently, therapeutic scenario for cardiovascular diseases (CVD) offers a plethora widely validated functional pharmacological treatments improve health status patients. However, patients increasingly sceptical which often associated with moderate severe side The aim our review is provide collection most recent scientific on common phytochemicals, used centuries Mediterranean diet traditional chinese medicine act key regulators inflammation, could constitute important tools CVD management.

Язык: Английский

Процитировано

0