DNA Extracellular Traps Released by Mayaro Virus‐Infected Macrophages Act as a Platform for Virus Dissemination DOI
Ana Sofía Carvalho, Gean Carlo Pereira‐Silva, Jessica Cristiane da Conceição de Andrade

и другие.

Journal of Medical Virology, Год журнала: 2025, Номер 97(3)

Опубликована: Фев. 25, 2025

ABSTRACT Mayaro virus (MAYV) is an arthritogenic arbovirus that causes a debilitating illness can progress to chronic rheumatic disease characterized by persistent viral replication in macrophages within joint tissues. Here, we report MAYV‐infected release decondensed DNA traps (DNA extracellular traps, DETs) through mechanism driven the production of reactive oxygen species and peptidyl arginine deiminase activation, resembling classical pathogen clearance activated neutrophils. Unlike traditional observed for NETs released neutrophils, MAYV‐induced DETs did not inactivate virus. Instead, DET‐ensnared viruses are internalized neighboring uninfected macrophages, increasing number infected cells. Collectively, these findings suggest MAYV‐containing act as “Trojan horse” facilitates dissemination inflamed tissues, connecting macrophage‐mediated inflammatory response persistence articular tissue MAYV disease.

Язык: Английский

DNA Extracellular Traps Released by Mayaro Virus‐Infected Macrophages Act as a Platform for Virus Dissemination DOI
Ana Sofía Carvalho, Gean Carlo Pereira‐Silva, Jessica Cristiane da Conceição de Andrade

и другие.

Journal of Medical Virology, Год журнала: 2025, Номер 97(3)

Опубликована: Фев. 25, 2025

ABSTRACT Mayaro virus (MAYV) is an arthritogenic arbovirus that causes a debilitating illness can progress to chronic rheumatic disease characterized by persistent viral replication in macrophages within joint tissues. Here, we report MAYV‐infected release decondensed DNA traps (DNA extracellular traps, DETs) through mechanism driven the production of reactive oxygen species and peptidyl arginine deiminase activation, resembling classical pathogen clearance activated neutrophils. Unlike traditional observed for NETs released neutrophils, MAYV‐induced DETs did not inactivate virus. Instead, DET‐ensnared viruses are internalized neighboring uninfected macrophages, increasing number infected cells. Collectively, these findings suggest MAYV‐containing act as “Trojan horse” facilitates dissemination inflamed tissues, connecting macrophage‐mediated inflammatory response persistence articular tissue MAYV disease.

Язык: Английский

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