Antioxidants, Год журнала: 2024, Номер 13(12), С. 1529 - 1529

Опубликована: Дек. 13, 2024

Alzheimer’s disease (AD) is a polygenic, multifactorial neurodegenerative disorder and remains the most prevalent form of dementia, globally. Despite decades research efforts, there still no effective cure for this debilitating condition. AD has increasingly focused on transcription factor NRF2 (nuclear erythroid 2-related 2) as potential therapeutic target. plays crucial role in protecting cells tissues from environmental stressors, such electrophiles reactive oxygen species. Recently, an increasing number studies have demonstrated that key regulator pathology. highly expressed microglia, resident macrophages central nervous system, contributes to neuroinflammation, phagocytosis neurodegeneration AD. been reported modulate microglia-induced inflammation facilitate transition homeostatic microglia disease-associated subset. Genetic pharmacological activation improve cognitive function. Here, we review current understanding involvement critical context Our aim highlight targeting promising strategy mitigating progression

Язык: Английский