Neuronal Plasticity-Dependent Paradigm and Young Plasma Treatment Prevent Synaptic and Motor Deficit in a Rett Syndrome Mouse Model DOI Creative Commons
Sofía Espinoza,

Camila Navia,

Rodrigo F. Torres

и другие.

Biomolecules, Год журнала: 2025, Номер 15(5), С. 748 - 748

Опубликована: Май 21, 2025

Classical Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the MECP2 gene, resulting devastating phenotype associated with lack of gene expression control. Mouse models lacking Mecp2 an RTT-like have been developed to advance therapeutic alternatives. Environmental enrichment (EE) attenuates RTT symptoms patients and mouse models. However, mechanisms underlying effects EE on not fully elucidated. We housed male hemizygous Mecp2-null (Mecp2-/y) wild-type mice specially conditioned cages enhance sensory, cognitive, social, motor stimulation. attenuated progression preserving neuronal cytoarchitecture neural plasticity markers. Furthermore, ameliorated defects neuromuscular junction organization restored deficit Mecp2-/y mice. Treatment plasma from young WT was used assess whether increased activity could modify components, mimicking benefits Mecp2-/y. Plasma treatment improving neurological markers, suggesting that peripheral signals normal function potential reactivate dormant neurodevelopment These findings demonstrate how ameliorate mice, opening new therapeutical approaches for patients.

Язык: Английский

Neuronal Plasticity-Dependent Paradigm and Young Plasma Treatment Prevent Synaptic and Motor Deficit in a Rett Syndrome Mouse Model DOI Creative Commons
Sofía Espinoza,

Camila Navia,

Rodrigo F. Torres

и другие.

Biomolecules, Год журнала: 2025, Номер 15(5), С. 748 - 748

Опубликована: Май 21, 2025

Classical Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the MECP2 gene, resulting devastating phenotype associated with lack of gene expression control. Mouse models lacking Mecp2 an RTT-like have been developed to advance therapeutic alternatives. Environmental enrichment (EE) attenuates RTT symptoms patients and mouse models. However, mechanisms underlying effects EE on not fully elucidated. We housed male hemizygous Mecp2-null (Mecp2-/y) wild-type mice specially conditioned cages enhance sensory, cognitive, social, motor stimulation. attenuated progression preserving neuronal cytoarchitecture neural plasticity markers. Furthermore, ameliorated defects neuromuscular junction organization restored deficit Mecp2-/y mice. Treatment plasma from young WT was used assess whether increased activity could modify components, mimicking benefits Mecp2-/y. Plasma treatment improving neurological markers, suggesting that peripheral signals normal function potential reactivate dormant neurodevelopment These findings demonstrate how ameliorate mice, opening new therapeutical approaches for patients.

Язык: Английский

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