Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 3, 2025

Lethal alleles are mutations in the genome that cause embryonic losses affected homozygous embryos and, therefore, can negatively influence reproduction rates commercial populations. Thus, this study aimed to identify genomic regions containing potential lethal haplotypes Nellore breed; candidate genes located within these regions; and investigate reproductive performance of heterozygous carriers cattle. Forty-five harboring putative were identified, which overlap with 360 genes. Gene ontology analyses revealed biological processes associated development sexual traits males females, key functions immune system, energy homeostasis, development. The gene networks involved metabolic pathways including ovarian steroidogenesis, oocyte meiosis, insulin secretion. Matings between carrier dam sire led a reduction up -203.46% pregnancy success probability, an increase 275.15% probability loss, 295.03% for stillbirth occurrence, 301.40% pre-weaning mortality when compared non-carrier matings. results highlight importance identifying animals avoid propagation population.

Язык: Английский

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Is it possible to select body weight without compromising carcass traits and reproductive efficiency in Caracu cattle?

Journal of Applied Genetics, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Язык: Английский

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Introducing alternative nonlinear models to characterize growth curves in goats

Tropical Animal Health and Production, Год журнала: 2025, Номер 57(3)

Опубликована: Март 18, 2025

Язык: Английский

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Trait development and genetic parameters of resilience indicators based on variability in milk consumption recorded by automated milk feeders in North American Holstein calves

Journal of Dairy Science, Год журнала: 2024, Номер 107(12), С. 11180 - 11194

Опубликована: Авг. 30, 2024

Язык: Английский

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Effects of inbreeding on production traits and genetic evaluations in Guzerá beef cattle raised under tropical conditions

Tropical Animal Health and Production, Год журнала: 2024, Номер 56(4)

Опубликована: Апрель 20, 2024

Язык: Английский

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Genotype‐by‐environment interactions in beef and dairy cattle populations: A review of methodologies and perspectives on research and applications

Animal Genetics, Год журнала: 2024, Номер 55(6), С. 871 - 892

Опубликована: Окт. 8, 2024

Abstract Modern livestock production systems are characterized by a greater focus on intensification, involving managing larger numbers of animals to achieve higher productive efficiency and animal health welfare within herds. Therefore, breeding programs need be strategically designed select that can effectively enhance performance across range environmental conditions. Thus, this review summarizes the main methodologies used for assessing levels genotype‐by‐environment interaction (G × E) in cattle populations. In addition, we explored importance integrating genomic phenotypic information quantify account G E programs. An overview structure is provided give insights into potential outcomes challenges faced when considering optimize genetic gains The role nutrigenomics its impact gene expression related metabolism also discussed, along with an examination current research findings their implications future practical applications. Out 116 studies examined, 60 56 focused beef dairy cattle, respectively. A total 83.62% these reported correlations gradients below 0.80, indicating presence E. For 69.33%, 24%, 2.67%, 1.33% evaluated growth, reproduction, carcass meat quality, survival, feed traits, By contrast, populations predominantly milk yield composition (79.36% studies), followed reproduction fertility (19.05%), survival (1.59%) traits. becomes particularly evident complex traits such as heat tolerance, disease resistance, reproductive performance, efficiency, highlighted review. Genomic models provide valuable avenue studying depth, allowing identification candidate genes metabolic pathways associated fitness, adaptation, efficiency. Nutrigenetics emerging fields require extensive investigation maximize our understanding gene–nutrient interactions. various transcription factors, potentially improve metabolism, improving health, quality products milk.

Язык: Английский

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Genome-wide association studies and functional annotation of pre-weaning calf mortality and reproductive traits in Nellore cattle from experimental selection lines

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Дек. 18, 2024

Язык: Английский

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