Composite dietary antioxidant index associated with delayed biological aging: a population-based study

Aging, Год журнала: 2024, Номер unknown

Опубликована: Янв. 2, 2024

Objective: The objective of this study was to explore the potential correlation between composite dietary antioxidant index (CDAI) and biological aging, addressing insufficient epidemiological evidence in area. Methods: Participants meeting eligibility criteria were selected from National Health Nutrition Examination Surveys (NHANES) conducted 2001 2018. CDAI determined based on antioxidants obtained 24-hour recalls. Biological age using PhenoAge algorithms incorporating various clinical features. Weighted multiple models employed investigate assess association age. Results: Analysis quartile revealed disparities terms age, gender, ethnicity, educational level, marital status, poverty, calories intakes, smoking, drinking BMI, physical activity, PhenoAge. After adjusting for confounding factors, a significant inverse relationship found Phenotypic Age, with each standard deviation increase score correlating 0.18-year decrease Age. These negative correlations advancement observed regardless activity smoking body mass index. Conclusions: Our findings demonstrate positive higher scores delayed aging. results have implications public health initiatives aimed at promoting healthy aging through interventions.

Язык: Английский

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In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities with molecular modeling simulation

Drug Development Research, Год журнала: 2022, Номер 84(1), С. 3 - 24

Опубликована: Ноя. 15, 2022

Abstract The strategy of utilizing nitrogen compounds in various biological applications has recently emerged as a powerful approach to exploring novel classes therapeutics face the challenge diseases. A series pyrazolo[1,5‐ ]pyrimidine‐based 3a–l and 5a–f were prepared by direct cyclo‐condensation reaction 5‐amino‐1 H ‐pyrazoles 1a, b with 2‐(arylidene)malononitriles 3‐(dimethylamino)‐1‐aryl‐prop‐2‐en‐1‐ones, respectively. structures new ]pyrimidine confirmed via spectroscopic techniques. vitro activities all ]pyrimidines evaluated assaying total antioxidant capacity, iron‐reducing power, scavenging activity against 1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) 2, 2'‐azinobis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) radicals, anti‐diabetic, anti‐Alzheimer, anti‐arthritic activities. All displayed good potent bioactivity, three 3g, 3h , 3l most active derivatives. Among these derivatives, compound exhibited highest (total capacity [TAC] = 83.09 mg gallic acid/g; power [IRP] 47.93 µg/ml) free radicals (DPPH 18.77 µg/ml; ABTS 40.44%) compared ascorbic acid 4.28 38.84%). Furthermore, demonstrated strongest inhibition α‐amylase percent 72.91 ± 0.14 acarbose 67.92 0.09%. Similarly, it acetylcholinesterase 62.80 0.06%. However, 3i showed significantly higher percentage for protein denaturation proteinase at 20.66 0.00 26.42 0.06%, Additionally, some silico ADMET properties predicted studied. Finally, molecular docking simulation was performed inside site study their interactions.

Язык: Английский

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Ergothioneine and its prospects as an anti-ageing compound

Experimental Gerontology, Год журнала: 2022, Номер 170, С. 111982 - 111982

Опубликована: Окт. 14, 2022

Healthy ageing is a crucial process that needs to be highlighted as it affects the quality of lifespan. An increase in oxidative stress along with major factor related age-associated diseases, especially neurodegenerative disorders. antioxidant-rich diet has been proven play significant role process. Targeting mechanisms could worthwhile approach improving health standards. Ergothioneine (EGT), hydrophilic compound specific transporter known OCTN1, shown exert anti-ageing properties. In addition its antioxidant effect, EGT reported have anti-senescence, anti-inflammatory and anti-neurodegenerative This review aims define pivotal signalling pathways such insulin/insulin-like growth (IGF) (IIS), sirtuin 6 (SIRT6) mammalian target rapamycin complex (mTOR) pathways. The further discusses evidence on neurodegeneration therapeutic context various model organisms, providing new insights into health. conclusion, an ergothioneine-rich may beneficial preventing age-related resulting healthy population.

Язык: Английский

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Inflammatory markers and physical frailty: towards clinical application

Immunity & Ageing, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 6, 2024

Abstract Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and considered an important indicator of adverse events in older population. Therefore, there growing interest early diagnosis intervention frailty, but cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation related to function increased disease risk. Additionally, multiple human animal studies suggest that probably plays largest role contributing frailty. Some inflammatory markers have been proposed predict However, large gaps knowledge clinical application these frail patients. understanding biological processes identifying recognized reliable urgent pivotal tasks geriatricians. In present review, we broadly summarize may potential diagnostic therapeutic use, thereby translating them into people near future.

Язык: Английский

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Review of biological activities: A plant of traditional Chinese tonic

Journal of Ethnopharmacology, Год журнала: 2024, Номер 332, С. 118334 - 118334

Опубликована: Май 11, 2024

Язык: Английский

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Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions

Metabolites, Год журнала: 2024, Номер 14(6), С. 327 - 327

Опубликована: Июнь 11, 2024

Several hallmarks of metabolic syndrome, such as dysregulation in the glucose and lipid metabolism, endothelial dysfunction, insulin resistance, low-to-medium systemic inflammation, intestinal microbiota dysbiosis, represent a pathological bridge between syndrome diabesity, cardiovascular, neurodegenerative disorders. This review aims to highlight some therapeutic strategies against involving integrative approaches improve lifestyle daily diet. The beneficial effects foods containing antioxidant polyphenols, control, physical activity were also considered. We comprehensively examined large body published articles basic, animal, human studie, well recent guidelines. As result, dietary polyphenols from natural plant-based antioxidants adherence Mediterranean diet, along with exercise, are promising complementary therapies delay or prevent onset counteract diabesity cardiovascular diseases, protect disorders cognitive decline. Modulation reduces risks associated MS, improves diabetes diseases (CVD), exerts neuroprotective action. Despite several studies, estimation polyphenol intake is inconclusive requires further evidence. Lifestyle interventions reduced calorie can outcomes.

Язык: Английский

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Effects of puerarin as a feed additive on the laying performance, egg quality, endocrine hormones, antioxidant capacity, and intestinal morphology of aged laying hens

Poultry Science, Год журнала: 2024, Номер 103(5), С. 103420 - 103420

Опубликована: Янв. 9, 2024

The aim of this study was to investigate the effects puerarin (Pue), a phytoestrogen, on production performance, egg quality, endocrine hormones, antioxidant capacity, and intestinal morphology in aged laying hens. A total 180 Hy-Line Brown hens 480 d were randomly divided into 4 groups (n = 45 per group) fed 0, 200, 400, 800 mg/kg Pue (Con, L-Pue, M-Pue, H-Pue, respectively) during 42-d experiment. Compared with Con treatment, supplementation H-Pue improved performance quality by significantly increasing production, average weight, albumen height, yolk Haugh unit (P < 0.05) while decreasing feed conversion ratio 0.05). diet supplemented serum triglycerides, cholesterol, low-density lipoprotein alanine aminotransferase 0.05), levels follicle-stimulating hormone, luteinizing hormone progesterone Antioxidant activity glutathione peroxidase catalase but malondialdehyde serum, jejunum, ileum superoxide dismutase exhibited increase jejunum Villus height villus crypt depth increased ileum. In jejunal ileal mucosa, three treatment mRNA expression Claudin-1 Claudin-2 compared no significant effect observed Occludin ZO-1. results showed that dietary could improve hormonal profile,

Язык: Английский

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Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions

Antioxidants, Год журнала: 2025, Номер 14(1), С. 108 - 108

Опубликована: Янв. 18, 2025

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.

Язык: Английский

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Association between Biological Aging and Cardiovascular Health: Combined Evidence based on Cross-sectional and Prospective Study

Archives of Gerontology and Geriatrics, Год журнала: 2025, Номер 132, С. 105785 - 105785

Опубликована: Фев. 15, 2025

Язык: Английский

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Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases

Antioxidants, Год журнала: 2023, Номер 12(12), С. 2091 - 2091

Опубликована: Дек. 8, 2023

Metabolic syndrome (MS) is a growing disorder affecting thousands of people worldwide, especially in industrialised countries, increasing mortality. Oxidative stress, hyperglycaemia, insulin resistance, inflammation, dysbiosis, abdominal obesity, atherogenic dyslipidaemia and hypertension are important factors linked to MS clusters different pathologies, such as diabesity, cardiovascular diseases neurological disorders. All biochemical changes observed MS, dysregulation the glucose lipid metabolism, immune response, endothelial cell function intestinal microbiota, promote pathological bridges between metabolic syndrome, diabesity neurodegenerative This review aims summarise syndrome's involvement highlight link diseases. A better understanding could novel strategic approach reduce comorbidities.

Язык: Английский

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