Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects
Current Obesity Reports,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 3, 2025
Язык: Английский
Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 30, 2025
Introduction
Ulcerative
colitis
(UC)
is
a
global
gastrointestinal
disease,
which
mainly
caused
by
both
dysfunctional
epithelial
barrier
and
inflammation
response.
Iron
critical
fundamental
element
for
the
maintenance
of
homeostasis
mediation
in
many
tissues.
However,
role
mechanism
iron
phase
enteritis
subsequent
repairing
intestinal
stem
cells
has
not
been
elucidated.
In
this
study,
we
aimed
to
explore
whether
how
depletion
would
affect
occurrence
outcome
experimental
colitis.
Methods
was
realized
deferoxamine
(DFO)
at
either
early
stage
or
late
dextran
sulfate
sodium
(DSS)
induced
mice.
The
gross
images
colons,
general
health,
histology,
integrity,
qRT-PCR
were
performed.
Meanwhile,
cell
culture
colonic
organoids
used
examine
influence
vitro
.
Signaling
pathway
inflammatory
infiltration
investigated
immunostaining.
Results
within
DSS
treatment
significantly
inhibited
onset
response,
maintained
integrity
epithelium,
preserved
activity
(ISCs)
vivo
continuous
DFO
aggravated
injury
postponed
recovery
from
Early
DFO-induced
able
maintain
p-STAT3
p-ERK1/2
signaling
pathways
epithelium
colitis,
but
these
two
pathways.
Discussion
Our
study
demonstrated
that
manipulation
might
greatly
outcomes
phase-dependent
manner,
suggests
balance
metabolism
be
an
effective
therapeutic
target
clinical
IBD
patients.
Язык: Английский
Rocaglamide regulates iron homeostasis by suppressing hepcidin expression
Free Radical Biology and Medicine,
Год журнала:
2024,
Номер
219, С. 153 - 162
Опубликована: Апрель 23, 2024
Язык: Английский
High-throughput point-of-care serum iron testing utilizing machine learning-assisted deep eutectic solvent fluorescence detection platform
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
680, С. 389 - 404
Опубликована: Ноя. 17, 2024
Язык: Английский
Identification of iron metabolism-related genes in coronary heart disease and construction of a diagnostic model
Lin Zhu,
Jianxin Zhang,
Wenhui Fan
и другие.
Frontiers in Cardiovascular Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 14, 2024
Background
Coronary
heart
disease
is
a
common
cardiovascular
disease,
yferroptosiset
its
relationship
with
iron
metabolism
remains
unclear.
Methods
Gene
expression
data
from
peripheral
blood
samples
of
patients
coronary
and
healthy
control
group
were
utilized
for
comprehensive
analysis
that
included
differential
analysis,
weighted
gene
co-expression
network
enrichment
the
development
logistic
regression
model
to
investigate
associations
differences
between
groups.
Additionally,
CIBERSORT
algorithm
was
employed
examine
composition
immune
cell
types
within
samples.
Results
Eight
central
genes
identified
as
being
both
differentially
expressed
related
metabolism.
These
are
mainly
involved
in
cellular
stress
response.
A
based
on
achieved
an
AUC
0.64–0.65
diagnosis
disease.
higher
proportion
M0
macrophages
found
while
CD8T
cells
observed
normal
group.
Conclusion
The
study
important
pathogenesis
constructed
robust
diagnostic
model.
results
suggest
may
play
significant
role
providing
basis
further
research.
Язык: Английский
Association between inflammatory cytokines and disease severity in restless legs syndrome
Neurological Sciences,
Год журнала:
2024,
Номер
45(12), С. 5765 - 5770
Опубликована: Авг. 29, 2024
Язык: Английский
DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis
Free Radical Biology and Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Data-independent acquisition-based blood proteomics unveils predictive biomarkers for neonatal necrotizing enterocolitis
Analytical and Bioanalytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Necrotizing
enterocolitis
(NEC)
is
a
life-threatening
condition
affecting
preterm
infants,
sometimes
necessitating
surgical
treatment.
This
study
aimed
to
analyze
differentially
expressed
proteins
(DEPs)
and
access
their
biological
clinical
significance
in
the
plasma
of
neonates
with
NEC.
Peripheral
blood
samples
were
collected
from
NEC
infants
at
various
time
points,
was
separated.
Data-independent
acquisition
(DIA)
technology
utilized
identify
DEPs
among
patients
different
stages.
Bioinformatic
analyses,
including
Gene
Ontology
Kyoto
Encyclopedia
Genes
Genomes,
protein-to-protein
interaction
analyses
performed
on
DEPs.
External
datasets,
along
receiver
operating
characteristic
curves
gene
set
enrichment
analysis,
used
clinically
biologically
validate
findings.
between
pre-NEC
groups
indicated
reduced
protein,
heme,
nitrogen,
purine
nucleotide
biosynthesis
during
formation.
In
addition,
enriched
points
suggested
reconstructed
extracellular
matrix,
aberrant
B-lymphocyte
immune
responses,
decreased
glycosaminoglycan
levels
progression.
These
findings
both
validated
using
external
datasets.
Our
highlights
relevance
proteomics
patients.
demonstrates
key
pathways
involved
pathogenesis
establishes
DIA
mass
spectrometry
as
powerful
noninvasive
tool
for
evaluating
predicting
formation
Graphical
Язык: Английский