The role of cellular senescence in ovarian aging

npj Aging, Год журнала: 2024, Номер 10(1)

Опубликована: Июль 20, 2024

Abstract This review explores the relationship between ovarian aging and senescent cell accumulation, as well efficacy of senolytics to improve reproductive longevity. Reproductive longevity is determined by age-associated decline in reserve, resulting reduced fertility eventually menopause. Cellular senescence a state permanent cycle arrest resistance apoptosis. Senescent cells accumulate several tissues with advancing age, thereby promoting chronic inflammation age-related diseases. Ovaries also appear which might contribute system whole organism through SASP production. Importantly, senolytic drugs can eliminate may present potential intervention mitigate aging. Herein, we current literature related for extending window mice.

Язык: Английский

The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract One promising strategy to alleviate aging symptoms is the treatment with senolytics that compounds which selectively eliminate senescent cells. Some therapies aim reduce of cellular senescence without cell eradication (senomorphic activity). However, senotherapies raise many questions concerning selectivity, safety and efficiency senolitic drugs. A vital question how senolytic affect young proliferating In our study, we checked impact quercetin dasatinib (D + Q), one drug mixtures drugs, on chromatin structure in We analyzed effect a single triple vascular smooth muscle have shown D Q impacts both cells, caused some “rejuvenation” but cells changes characteristic were observed. The alterations appeared only transiently returned initial state after 24 h recovery. complexity staining nucleus morphology evaluation indicated makes more similar ones than treatment. analysis markers suggested slightly less pronounced characteristics was efficient alleviating features It still an open whether by are beneficial or harmful long term; however, so far, it can be concluded effects depend type physiological context.

Язык: Английский

Increased hydrogen sulfide turnover serves a cytoprotective role during the development of replicative senescence

Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116595 - 116595

Опубликована: Окт. 1, 2024

Язык: Английский