Genetic determinants of COVID-19 vaccine antibody response and breakthrough infection risk: genome-wide association studies based on UK biobank data DOI Creative Commons
Daniel Prieto‐Alhambra,

Marta Alcalde Herraiz,

Martí Català

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 21, 2023

Abstract Understanding the genetic basis of COVID-19 vaccine immune response is crucial to study role genetics on effectiveness. In our study, we used UK Biobank data find determinants vaccine-induced immunity and breakthrough infections. We conducted four genome-wide association studies among vaccinated participants for antibody responses susceptibility severity. Our findings confirmed a link between HLA region humoral after first second doses. Additionally, identified 6 genomic regions associated with infection (SLC6A20, ST6GAL1, MXI1, MUC16, FUT6, FUT2) one severity (AC024590.1-RP11-481E4.1). also observed that FUT2 loci colocalise one-dose infection, suggesting potential shared root these two traits. This provides novel evidence variants influence risk outcomes in population.

Язык: Английский

Discovery, classification, evolution and diversity of Siglecs DOI Creative Commons
Takashi Angata, Ajit Varki

Molecular Aspects of Medicine, Год журнала: 2022, Номер 90, С. 101117 - 101117

Опубликована: Авг. 18, 2022

Язык: Английский

Процитировано

44
Defining diverse Spike-Receptor interactions involved in SARS-CoV-2 entry: Mechanisms and Therapeutic Opportunities DOI Creative Commons
Michael Anderson,

Julian Lopez,

Maya Wyr

и другие.

Virology, Год журнала: 2025, Номер unknown, С. 110507 - 110507

Опубликована: Март 1, 2025

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an enveloped RNA virus that caused the Disease 2019 (COVID-19) pandemic. The SARS-CoV-2 Spike glycoprotein binds to angiotensin converting enzyme (ACE2) on host cells facilitate viral entry. However, presence of in nearly all human organs - including those with little or no ACE2 expression suggests involvement alternative receptors. Recent studies have identified several cellular proteins and molecules influence entry through ACE2-dependent, ACE2-independent, inhibitory mechanisms. In this review, we explore how these receptors were identified, their patterns roles entry, impact infection. Additionally, discuss therapeutic strategies aimed at disrupting virus-receptor interactions mitigate COVID-19 pathogenesis.

Язык: Английский

Процитировано

2
Roles of Siglecs in neurodegenerative diseases DOI
Jian Jing Siew, Yijuang Chern, Kay‐Hooi Khoo

и другие.

Molecular Aspects of Medicine, Год журнала: 2022, Номер 90, С. 101141 - 101141

Опубликована: Сен. 9, 2022

Язык: Английский

Процитировано

16
Preclinical development of humanized monoclonal antibodies against CD169 as a broad antiviral therapeutic strategy DOI Open Access
Patricia Resa‐Infante, Itziar Erkizia, Xabier Muñiz-Trabudua

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116726 - 116726

Опубликована: Май 15, 2024

New therapies to treat or prevent viral infections are essential, as recently observed during the COVID-19 pandemic. Here, we propose a therapeutic strategy based on monoclonal antibodies that block specific interaction between host receptor Siglec-1/CD169 and gangliosides embedded in envelope. Antibodies an excellent option for treating infectious diseases their high specificity, strong targeting affinity, relatively low toxicity. Through process of humanization, optimized eliminate sequence liabilities performed biophysical characterization. We demonstrated they maintain ability entry into myeloid cells. These molecular improvements discovery stage key if maximize efforts develop new strategies. Humanized CD169 provide opportunities treatment caused by ganglioside-containing enveloped viruses, which pose constant threat human health. In contrast with current neutralizing bind antigens particle, our can several types viruses interacting cells because target protein, thus becoming potential pan-antiviral therapy.

Язык: Английский

Процитировано

3
Exploring CD169+ Macrophages as Key Targets for Vaccination and Therapeutic Interventions DOI Creative Commons
Rianne G. Bouma,

Aru Z. Wang,

Joke M. M. den Haan

и другие.

Vaccines, Год журнала: 2025, Номер 13(3), С. 330 - 330

Опубликована: Март 20, 2025

CD169 is a sialic acid-binding immunoglobulin-like lectin (Siglec-1, sialoadhesin) that expressed by subsets of tissue-resident macrophages and circulating monocytes. This receptor interacts with α2,3-linked Neu5Ac on glycoproteins as well glycolipids present the surface immune cells pathogens. CD169-expressing exert tissue-specific homeostatic functions, but they also have opposing effects response. CD169+ act pathogen filter, protect against infectious diseases, enhance adaptive immunity, at same time pathogens exploit them to enable further dissemination. In cancer, in tumor-draining lymph nodes are correlated better clinical outcomes. inflammatory expression upregulated monocytes monocyte-derived this correlates disease state. Given their role promoting currently investigated targets for vaccination strategies cancer. review, we describe studies investigating importance several settings under investigation.

Язык: Английский

Процитировано

0
Non-canonical roles of Siglecs: Beyond sialic acid-binding and immune cell modulation DOI
Shoib Sarwar Siddiqui

Molecular Aspects of Medicine, Год журнала: 2022, Номер 90, С. 101145 - 101145

Опубликована: Сен. 22, 2022

Язык: Английский

Процитировано

13
Roles for Siglec-glycan interactions in regulating immune cells DOI Creative Commons

S. C. Lin,

Edward N. Schmidt, Kei Takahashi

и другие.

Seminars in Immunology, Год журнала: 2024, Номер 77, С. 101925 - 101925

Опубликована: Дек. 19, 2024

Язык: Английский

Процитировано

2
Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination DOI Creative Commons
Clara Duran-Castells, Anna Prats, Bruna Oriol-Tordera

и другие.

EBioMedicine, Год журнала: 2023, Номер 95, С. 104732 - 104732

Опубликована: Июль 26, 2023

Язык: Английский

Процитировано

4
Siglec7 functions as an inhibitory receptor of non-specific cytotoxic cells and can regulate the innate immune responses in a primitive vertebrate (Oreochromis niloticus) DOI
Zhiqiang Zhang, Xing Li,

Meiling Huang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134851 - 134851

Опубликована: Авг. 22, 2024

Язык: Английский

Процитировано

1
“Glycans in Trained Immunity: educators of innate immune memory in homeostasis and disease” DOI Creative Commons
Pedro Milanez‐Almeida, Ângela Fernandes, Inês Alves

и другие.

Carbohydrate Research, Год журнала: 2024, Номер 544, С. 109245 - 109245

Опубликована: Авг. 22, 2024

Trained Immunity is defined as a biological process normally induced by exogenous or endogenous insults that triggers epigenetic and metabolic reprogramming events associated with long-term adaptation of innate immune cells. This trained phenotype confers enhanced responsiveness to subsequent triggers, resulting in an "memory" effect. Immunity, the past decade, has revealed important benefits for host defense homeostasis, but can also induce potentially harmful outcomes chronic inflammatory disorders autoimmune diseases. Interestingly, evidence suggest "trainers" prompting immunity are frequently glycans structures. In fact, exposure different types at surface pathogens key driver training phenotype, leading cells through recognition those glycan-triggers variety glycan-binding proteins (GBPs) expressed β-glucan mannose-enriched structures Candida albicans some examples highlight potential immunity, both homeostasis disease. this review, we will discuss relevance exposed establishing immunological hubs glycan-recognizing receptors cells, highlighting how glycan-GBP network impact immunity. Finally, power GBPs targets envisioning therapeutic applications.

Язык: Английский

Процитировано

1