Pakistan Journal of Health Sciences,
Год журнала:
2024,
Номер
unknown, С. 240 - 247
Опубликована: Окт. 31, 2024
Glaucoma,
a
leading
cause
of
irreversible
blindness,
is
increasingly
recognized
as
neurodegenerative
disease
affecting
broader
neuro-ophthalmic
pathways.
Brain-derived
neurotrophic
Factor
crucial
neurotrophin,
that
supports
the
growth,
maintenance,
and
survival
neurons
has
been
implicated
in
glaucomatous
damage
where
its
levels
are
diminished.
Objectives:
To
focus
on
role
Brain-Derived
Neurotrophic
pathophysiology
glaucoma
therapeutic
potential
by
enhancing
retinal
ganglion
cells.
Methods:
The
studies
this
review
taken
from
well-known
public
libraries
for
scientific
research
such
PubMed
(60%),
Science
Direct
(25%)
Springer
Link
(15%),
line
with
PRISMA
guidelines.
Various
works
conducted
over
past
decade
different
parts
world,
including
North
America,
Europe,
Asia,
have
provided
evidence
augmentation
signalling
may
be
very
effective
approach
to
managing
or
halting
progression
optic
neuropathy
through
neuroprotection
improving
cells
survival.
Results:
Studies
both
animals
humans
indicate
downstream
signals
promote
decrease
extent
apoptotic
cell
death,
oxidative
stress,
inflammation
glaucoma.
Moreover,
enhancements
neuroprotective
effects
supported
factors
Nerve
growth
factor
Factor.
Conclusion:
It
was
concluded
used
diagnostic
marker
Glaucoma
well
it
could
evaluated
against
disease.
Neural Regeneration Research,
Год журнала:
2024,
Номер
20(12), С. 3501 - 3516
Опубликована: Дек. 16, 2024
Vision
restoration
presents
a
considerable
challenge
in
the
realm
of
regenerative
medicine,
while
recent
progress
ultrasound
stimulation
has
displayed
potential
as
non-invasive
therapeutic
approach.
This
narrative
review
offers
comprehensive
overview
current
research
on
ultrasound-stimulated
neuromodulation,
emphasizing
its
treatment
modality
for
various
nerve
injuries.
By
examining
efficacy
different
types
modulating
peripheral
and
optic
nerves,
we
can
delve
into
their
underlying
molecular
mechanisms.
Furthermore,
underscores
sonogenetics
vision
restoration,
which
involves
leveraging
pharmacological
genetic
manipulations
to
inhibit
or
enhance
expression
related
mechanosensitive
channels,
thereby
strength
response.
We
also
address
how
methods
such
viral
transcription
be
utilized
render
specific
neurons
organs
highly
responsive
ultrasound,
leading
significantly
improved
outcomes.
Pakistan Journal of Health Sciences,
Год журнала:
2024,
Номер
unknown, С. 240 - 247
Опубликована: Окт. 31, 2024
Glaucoma,
a
leading
cause
of
irreversible
blindness,
is
increasingly
recognized
as
neurodegenerative
disease
affecting
broader
neuro-ophthalmic
pathways.
Brain-derived
neurotrophic
Factor
crucial
neurotrophin,
that
supports
the
growth,
maintenance,
and
survival
neurons
has
been
implicated
in
glaucomatous
damage
where
its
levels
are
diminished.
Objectives:
To
focus
on
role
Brain-Derived
Neurotrophic
pathophysiology
glaucoma
therapeutic
potential
by
enhancing
retinal
ganglion
cells.
Methods:
The
studies
this
review
taken
from
well-known
public
libraries
for
scientific
research
such
PubMed
(60%),
Science
Direct
(25%)
Springer
Link
(15%),
line
with
PRISMA
guidelines.
Various
works
conducted
over
past
decade
different
parts
world,
including
North
America,
Europe,
Asia,
have
provided
evidence
augmentation
signalling
may
be
very
effective
approach
to
managing
or
halting
progression
optic
neuropathy
through
neuroprotection
improving
cells
survival.
Results:
Studies
both
animals
humans
indicate
downstream
signals
promote
decrease
extent
apoptotic
cell
death,
oxidative
stress,
inflammation
glaucoma.
Moreover,
enhancements
neuroprotective
effects
supported
factors
Nerve
growth
factor
Factor.
Conclusion:
It
was
concluded
used
diagnostic
marker
Glaucoma
well
it
could
evaluated
against
disease.
