The AI Revolution in Glaucoma: Bridging Challenges with Opportunities

Progress in Retinal and Eye Research, Год журнала: 2024, Номер 103, С. 101291 - 101291

Опубликована: Авг. 25, 2024

Язык: Английский

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Utilizing systems genetics to enhance understanding into molecular targets of skin cancer

Experimental Dermatology, Год журнала: 2024, Номер 33(3)

Опубликована: Март 1, 2024

Despite progress made with immune checkpoint inhibitors and targeted therapies, skin cancer remains a significant public health concern in the United States. The intricacies of disease, encompassing genetics, responses, external factors, call for comprehensive approach. Techniques systems including transcriptional correlation analysis, functional pathway enrichment protein-protein interaction network prove valuable deciphering intricate molecular mechanisms identifying potential diagnostic therapeutic targets cancer. Recent studies demonstrate efficacy these techniques uncovering processes pinpointing markers various types, highlighting genetics advancing innovative therapies. While certain limitations exist, such as generalizability contextualization ongoing AI technologies provides hope overcoming challenges. By providing protocols practical example involving Braf, we aim to inspire early-career experimental dermatologists adopt tools seamlessly integrate into their research, positioning them at forefront approaches combating this devastating disease.

Язык: Английский

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Quantum machine learning in ophthalmology

Eye, Год журнала: 2024, Номер 38(15), С. 2857 - 2858

Опубликована: Июнь 29, 2024

Язык: Английский

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Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, and in vivo perspectives

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Июль 26, 2024

Parasympathetic activation in the anterior eye segment regulates various physiological functions. This process, mediated by muscarinic acetylcholine receptors, also impacts intraocular pressure (IOP) through trabecular meshwork. While FDA-approved M3 receptor (M3R) agonists exist for IOP reduction, their systemic cholinergic adverse effects pose limitations clinical use. Therefore, advancing our understanding of system is crucial developing additional IOP-reducing agents with improved safety profiles. Systems genetics analyses were utilized to explore correlations between and five major subtypes. Molecular docking dynamics simulations applied human M3R homology model using a comprehensive set ligands 1,667 or investigational drugs. Lead compounds from modeling studies then tested IOP-lowering abilities mice. unveiled positive mRNA expressions among subtypes, negative correlation observed only IOP. Through studies, rivastigmine edrophonium emerged as most optimally suited drugs reducing via potentially distinct mechanism pilocarpine physostigmine. Subsequent animal confirmed comparable reductions rivastigmine, edrophonium, pilocarpine, longer durations action edrophonium. Mild but absent These findings advance ocular therapeutics, suggesting more nuanced role parasympathetic than previously thought.

Язык: Английский

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Evaluation of Pregabalin bioadhesive multilayered microemulsion IOP-lowering eye drops

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 667 - 687

Опубликована: Авг. 1, 2024

Язык: Английский

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In silico exploration of phytochemicals as inhibitors for acute myeloid leukemia by targeting LIN28A gene: A cheminformatics study

Computers in Biology and Medicine, Год журнала: 2024, Номер 183, С. 109286 - 109286

Опубликована: Ноя. 5, 2024

Язык: Английский

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