Evaluating the Efficacy of Repurposed Antiretrovirals in Hepatitis B Virus Treatment: A Narrative Review of the Pros and Cons
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 925 - 925
Опубликована: Янв. 23, 2025
Human
immunodeficiency
virus
(HIV)
and
hepatitis
B
(HBV)
continue
to
be
global
public
health
issues.
Globally,
about
39.9
million
persons
live
with
HIV
in
2023,
according
the
Joint
United
Nations
Programme
on
HIV/AIDS
(UNAIDS)
2024
Fact
Sheet.
Consequently,
World
Health
Organisation
(WHO)
reported
that
1.5
new
cases
of
HBV
occur,
approximately
820
thousand
mortalities
yearly.
Conversely,
lower
percentage
(30%)
receive
a
diagnosis
is
setback
achieving
WHO
2030
target
for
zero
globally.
This
has
necessitated
concern
repurpose
antiretroviral
(ARV)
drugs
treatment
diseases.
review
provides
an
introductory
background,
including
pros
cons
repurposing
antiretrovirals
(ARVs)
treatment.
We
examine
similarities
replication
mechanisms
between
HBV.
further
investigate
some
clinical
studies
trials
co-infected
mono-infected
patients
HIV–HBV.
The
topical
keywords
ARV
drugs,
therapy,
Hepatitis
title,
abstracts
are
searched
PubMed,
Web
Science,
Google
Scholar.
advanced
search
includes
period
2014–2024,
full
text,
trials,
randomized
control
review.
results
filtered
from
361
51
relevant
articles.
investigations
revealed
replicate
via
common
route
known
as
‘reverse
transcription’.
Clinical
trial
indicate
early
initiation
ARVs,
particularly
tenofovir
disoproxil
fumarate
(TDF)
part
regimen,
significantly
reduced
viral
load
patients.
In
HBV,
timely
correct
precise
medication
essential
reduction.
Therefore,
genetic
profiling
pivotal
successful
drug
Pharmacogenetics
enables
prediction
right
dosages,
specific
individual
responses,
reactions.
study
uniquely
explores
intersection
pharmacogenetics
optimized
therapy.
Additional
vivo,
silico
research
important
validation
potency,
optimum
dosage,
safety
repurposed
Furthermore,
prioritization
collaborations
comprising
regulators
funders
foster
clinically
adopting
incorporating
ARVs
therapy
recommended.
Язык: Английский
Therapeutic potential of Baicalin against experimental obsessive compulsive disorder: Evidence from CSF, blood plasma, and brain analysis
Journal of Neuroimmunology,
Год журнала:
2025,
Номер
unknown, С. 578598 - 578598
Опубликована: Март 1, 2025
Язык: Английский
Oxidative Stress Enhances Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1041 - 1041
Опубликована: Янв. 25, 2025
Rubella
infection
(RuV)
during
early
pregnancy
is
a
known
cause
of
congenital
rubella
syndrome
(CRS).
However,
the
mechanisms
by
which
virus
crosses
placenta
and
infects
fetus
are
not
fully
understood.
It
has
been
that
various
kinds
cell
stresses
can
occur
formation.
Previously,
we
demonstrated
low-glucose-induced
endoplasmic
reticulum
stress
could
drastically
enhance
RuV
in
immortalized
human
first-trimester
trophoblast
cells.
In
this
study,
investigated
roles
oxidative
these
Oxidative
was
induced
Swan.71
cells
culturing
them
medium
containing
hydrogen
peroxide
(H2O2)
concentrations
durations
(50
µM
or
100
for
24
h,
150
1
h).
with
clinical
strain
performed
h
post-treatment,
capsid
proteins
were
visualized
at
48
post-infection
(hpi)
using
flow
cytometry
(FCM)
fluorescence
microscopy
(IF),
respectively.
The
findings
significantly
enhanced
infection,
as
evidenced
FCM
analysis,
showing
twofold
increase
rate,
confirmed
IF
assay.
Additionally,
increased
intracellular
viral
replication
observed
3
dpi.
These
suggest
may
promote
maternal-to-fetal
transmission
rubella,
contributing
to
development
CRS.
Язык: Английский
The role of cellular lipid metabolism and lipid-lowering drugs in periodontitis
International Immunopharmacology,
Год журнала:
2025,
Номер
152, С. 114434 - 114434
Опубликована: Март 13, 2025
Язык: Английский
Preeclampsia: A comprehensive review
Clinica Chimica Acta,
Год журнала:
2024,
Номер
563, С. 119922 - 119922
Опубликована: Авг. 13, 2024
Язык: Английский
A global lipid map of severe fever with thrombocytopenia syndrome virus infection reveals glycerophospholipids as novel prognosis biomarkers
mBio,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
Severe
fever
with
thrombocytopenia
syndrome
(SFTS)
is
a
rapidly
progressing
infectious
disease
caused
by
novel
bunyavirus
characterized
high
fever,
thrombocytopenia,
and
multiple
organ
damage.
While
lipids
play
an
important
role
in
viral
infections,
the
specific
alterations
lipid
metabolism
during
SFTSV
infection
remain
unclear.
This
study
aimed
to
elucidate
global
metabolic
profiles
of
SFTS
patients
mild,
severe,
fatal
outcomes.
A
total
60
patients,
consisting
30
15
severe
healthy
controls,
were
enrolled
for
investigation
lipidomics
serum
using
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS).
Our
findings
revealed
signature
induced
further
confirmed
that
glycerophospholipid
pathway
was
profoundly
affected
progression
outcomes
patients.
Importantly,
LysoPC
(20:0)
(P-16:0)
are
strongly
correlated
clinical
parameters
infection.
Furthermore,
we
demonstrated
substantial
prognostic
value
receiver
operating
characteristic
(ROC)
curve
analysis,
providing
evidence
their
remarkable
as
biomarkers
predicting
In
particular,
(P-16:0),
along
APTT,
yielded
superior
performance
[area
under
(AUC)
=
98.4%],
outperforming
routine
parameters.
Collectively,
our
lipidomic
landscape
after
infection,
which
offers
new
insights
into
mechanisms
suggests
targeting
may
serve
potential
therapeutic
strategy.
Язык: Английский
The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection
Virology Journal,
Год журнала:
2024,
Номер
21(1)
Опубликована: Дек. 19, 2024
The
Flaviviridae
family
includes
the
dengue
virus
(DENV).
About
half
of
world's
population
is
in
danger
because
estimated
390
million
infections
and
96
symptomatic
cases
that
occur
each
year.
An
effective
treatment
for
fever
(DF)
does
not
yet
exist.
Therefore,
a
better
knowledge
how
viral
proteins
virus-targeted
medicines
may
exert
distinct
functions
depending
on
exact
cellular
region
addressed
aid
creating
much-needed
antiviral
medications.
Lipids
facilitate
coordination
many
replication
phases,
from
entrance
to
dissemination.
In
addition,
flaviviruses
masterfully
plan
significant
rearrangement
host
cell's
lipid
metabolism
foster
growth
new
viruses.
Recent
research
has
consistently
shown
significance
certain
classes
flavivirus
infections.
For
instance,
DENV-infected
cells,
overall
cholesterol
(CHO)
levels
are
only
little
altered,
DENV
significantly
reduced
when
CHO
inhibited.
Moreover,
statins
decrease
serotype
2
(DENV-2)
titers,
indicating
prerequisite
cycle.
Furthermore,
Proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
inhibitors
now
being
evaluated
human
research.
A
pharmacological
target
management
high
PCSK9.
suppression
PCSK9
been
proposed
as
possible
defense
against
DENV.
Numerous
studies
have
generally
recommended
use
lipid-lowering
medications
suppress
As
result,
we
investigated
popular
techniques
this
We
also
examined
metabolism,
lipids,
receptors
affect
regulation.
Lastly,
looked
at
different
This
article
discusses
method's
future
based
its
benefits
drawbacks.
Язык: Английский