Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 8, 2025
In
previous
studies,
several
inflammatory
biomarkers
derived
from
complete
blood
cell
counts
(CBC),
such
as
systemic
immune
inflammation
index
(SII),
neutrophil-to-lymphocyte
ratio
(NLR),
and
non‑high‑density
lipoprotein
cholesterol
to
high‑density
(NHHR)
have
been
identified
predictors
of
sarcopenia.
However,
whether
Monocyte
High-Density
Lipoprotein
Cholesterol
Ratio
(MHR)
can
predict
the
development
sarcopenia
has
not
yet
established.
The
research
first
attempts
investigate
association
between
MHR
low
muscle
mass
compare
predictive
abilities
MHR,
SII,
NLR,
NHHR
for
risk.
study
comprised
10,321
participants
aged
20
years
above
United
States.
Multiple
logistic
regression
was
performed
explore
ln-transformed
mass.
Additionally,
AUC
values
ROC
curves
were
used
assess
effectiveness
ln
other
markers
(ln
NHHR,
+
NLR).
bootstrap
estimated
95%
Cl
shown
with
AUC.
fully
adjusted
model,
NLR
positively
associated
SII:
OR
=
1.59
[1.37-1.84];
NLR:
1.35
[1.13-1.60];
NHHR:
1.49[1.27-1.75];
MHR:
1.98
[1.68-2.33];
1.61
[1.46-1.79];
1.42
[1.29-1.56];
1.58
[1.41-1.78]).
Compared
lowest
quartile
higher
quartiles
significantly
increased
odds
(P
trend
<
0.0001).
analysis,
SII
had
a
value
than
indicators
(AUC
0.608).
Ln-transformed
outperforms
in
predicting
Язык: Английский
The Characteristic of Muscle Function for Sarcopenia in Patients with Rheumatoid Arthritis: A Large-Scale Real-World Cross-Sectional Study
Medicina,
Год журнала:
2025,
Номер
61(4), С. 551 - 551
Опубликована: Март 21, 2025
Background
and
Objectives:
Sarcopenia
is
a
notable
comorbidity
of
rheumatoid
arthritis
(RA),
affecting
about
one
third
patients.
However,
the
characteristic
muscle
function
its
association
with
RA
disease
remains
unknown.
Materials
Methods:
This
cross-sectional
study
collected
clinical
data
from
real-world
Chinese
cohort.
was
defined
as
both
myopenia
low
(LMF).
Myopenia
appendicular
skeletal
mass
index
(ASMI)
<
7.0
kg/m2
in
men
<5.7
women.
LMF
strength
(LMS,
hand
grip
28
kg
<18
women)
or
physical
performance
(LPP,
6
m
gait
speed
1.0
m/s).
Results:
Among
1125
patients
recruited
this
study,
928
were
eligible
for
analysis.
The
prevalence
sarcopenia,
myopenia,
LMF,
LMS,
LPP
all
36.5%,
46.1%,
69.0%,
57.8%,
37.1%,
respectively.
According
to
their
trends
age
activity,
there
111
(11.9%)
young
(age
50
years)
remission
(CDAI
≤
2.8)
subgroup,
199
(21.4%)
active
>
198
(21.3%)
old
≥
420
(45.2%)
subgroup.
Compared
two
subgroups,
respectively,
subgroup
had
significantly
lower
strength,
higher
worse
activity
function.
After
adjustment
potential
confounders,
multivariate
multinominal
logistic
regression
analysis
showed
that
positively
associated
sarcopenia
(OR
=
3.193,
95%CI:
1.477–6.899),
2.390,
1.207–4.731),
LMS
3.520,
1.743–7.110).
Conclusions:
Worse
rather
than
reduced
performance,
more
common
at
age.
It
underscores
critical
need
early
identification
intervention
dysfunction
improve
quality
life.
Язык: Английский