International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1605 - 1605

Опубликована: Фев. 13, 2025

Alexandrium pacificum, a dinoflagellate known for causing harmful algal blooms (HABs), has garnered significant attention due to its potential toxicity marine ecosystems, fisheries, and human health. However, the effects of this toxin-producing alga on shrimp are not yet comprehensively understood. This study aimed assess hepatopancreas damage induced by A. pacificum in economically important species E. carinicauda elucidate underlying molecular mechanisms through histology, antioxidant enzyme activity, transcriptome analysis. The were assigned either control group or an exposed group, with latter involving exposure at concentration 1.0 × 104 cells/mL 7 days. A histological analysis subsequently revealed pathological changes tissue including lumen expansion separation basement membrane from epithelial cells, while activity assays demonstrated that weakened defense system, as evidenced reduced activities catalase, superoxide dismutase, glutathione, along increased malondialdehyde levels. Transcriptome further identified 663 significantly upregulated genes 1735 downregulated ones these differentially expressed being primarily associated pathways such protein processing endoplasmic reticulum, mitophagy, glycolysis/gluconeogenesis, sphingolipid metabolism, glycerophospholipid metabolism. provides novel insights into toxicological aquatic organisms enhances current understanding ecotoxicological risks posed HABs.

Язык: Английский