The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 26, 2025

S100A4 is a Ca2+-binding protein involved in multiple chronic inflammatory and neoplastic conditions. This review focuses on recent advances the understanding of function immune cells, comparing contrasting regulation responses cancer diseases. We provide evidence that cell has profound role promoting pathogenesis pro-inflammatory Finally, we discuss relevant future directions to target therapeutically different disease states.

Язык: Английский

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Dan-shen Yin attenuates myocardial fibrosis after myocardial infarction in rats: molecular mechanism insights by integrated transcriptomics and network pharmacology analysis and experimental validation

Journal of Ethnopharmacology, Год журнала: 2024, Номер 338, С. 119070 - 119070

Опубликована: Ноя. 8, 2024

Язык: Английский

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Dexamethasone treatment influences tendon healing through altered resolution and a direct effect on tendon cells

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 3, 2024

Abstract Inflammation, corticosteroids, and loading all affect tendon healing, with an interaction between them. However, underlying mechanisms behind the effect of corticosteroids remain unclear. The aim this study was to investigate role dexamethasone during including specific effects on cells. Rats ( n = 36) were randomized heavy or mild loading, Achilles transected, animals treated saline. Gene protein analyses healing performed for extracellular matrix-, inflammation-, cell markers. We further tested cells in vitro. Dexamethasone increased mRNA levels S100A4 decreased ACTA2/α-SMA, irrespective load level. Heavy + reduced FN1 TenC p < 0.05), while resolution-related genes unaltered > 0.05). In contrast, ANXA1, MRC1, PDPN, PTGES 0.03). Altered confirmed tendons loading. treatment vitro prevented construct formation, SCX collagens. appears act through immunomodulation by promoting resolution, but also

Язык: Английский

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Molecular and Cellular Mediators of Renal Fibrosis in Lupus Nephritis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2621 - 2621

Опубликована: Март 14, 2025

Lupus nephritis (LN), a significant complication of systemic lupus erythematosus (SLE), represents challenging manifestation the disease. One prominent pathophysiologic mechanisms targeting renal parenchyma is fibrosis, terminal process resulting in irreversible tissue damage that eventually leads to decline function and/or end-stage kidney disease (ESKD). Both glomerulosclerosis and interstitial fibrosis emerge as reliable prognostic indicators outcomes. This article reviews hallmarks nephritis, including known putative drivers fibrogenesis. A better understanding cellular molecular processes driving LN may help inform development therapeutic strategies for this disease, well identification individuals at higher risk developing ESKD.

Язык: Английский

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Unique and shared transcriptomic signatures underlying localized scleroderma pathogenesis identified using interpretable machine learning

JCI Insight, Год журнала: 2025, Номер 10(7)

Опубликована: Апрель 7, 2025

Using transcriptomic profiling at single-cell resolution, we investigated cell-intrinsic and cell-extrinsic signatures associated with pathogenesis inflammation-driven fibrosis in both adult pediatric patients localized scleroderma (LS). We performed RNA-Seq on LS healthy controls. then analyzed the data using an interpretable factor analysis machine learning framework, significant latent interaction discovery exploration (SLIDE), which moves beyond predictive biomarkers to infer factors underlying pathophysiology. SLIDE is a recently developed regression-based framework that comes rigorous statistical guarantees regarding identifiability of factors, corresponding inference, FDR control. found distinct differences characteristics complexity molecular between LS. identified cell type-specific determinants age severity revealed insights into signaling mechanisms shared systemic sclerosis (SSc), as well onset disease compared population. Our analyses recapitulate known drivers pathology identify cellular modules stratify subtypes define axis SSc.

Язык: Английский

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Targeting a key pro-fibrotic factor S100A4 in cartilage to alleviate osteoarthritis progression and pain

Nano Today, Год журнала: 2025, Номер 63, С. 102755 - 102755

Опубликована: Апрель 15, 2025

Язык: Английский

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Ability of magnesium implants to remodel the osteoporotic immune microenvironment in a murine femoral fracture model

Rare Metals, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

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Damage-Associated Molecular Patterns (DAMPs) In Vascular Diseases

Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 110241 - 110241

Опубликована: Май 1, 2025

Research into the role of chronic sterile inflammation (i.e. a prolonged inflammatory state not caused by an infectious agent), in vascular disease progression has continued to grow over last few decades. DAMPs have critical this research due their ability link stress-causing cardiovascular risk factors phenotypes seen disease. In mini-review, we will briefly summarize and receptor signaling pathways that been extensively studied context disease, including TLRs, RAGE, cGAS-STING, NLRP3 inflammasome. particular, discuss how these can promote release pro-inflammatory cytokines chemokines as well remodeling. Next, results studies which linked various effects with diseases atherosclerosis, fibrosis, aneurysm, ischemia, hypertension. Finally, some pre-clinical clinical trials targeted DAMPs, receptors, or products pathways, outlook future directions for field at large.

Язык: Английский

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The RAGE Pathway in Skin Pathology Development: A Comprehensive Review of Its Role and Therapeutic Potential

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13570 - 13570

Опубликована: Дек. 18, 2024

The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, is expressed in various cell types and mediates cellular responses to wide range ligands. activation RAGE triggers complex signaling pathways that drive inflammatory, oxidative, proliferative responses, which are increasingly implicated pathogenesis skin diseases. Despite its well-established roles conditions such as diabetes, cancer, chronic inflammation, contribution pathologies remains underexplored. This review synthesizes current findings on RAGE’s involvement pathophysiology diseases, including psoriasis, atopic dermatitis, lichen planus, focusing inflammatory signaling, tissue remodeling, cancer progression. Additionally, it examines RAGE-modulating treatments investigated dermatological contexts, highlighting their potential therapeutic options. Given significance variety conditions, further research into mediated may uncover new opportunities targeted interventions skin-specific signaling.

Язык: Английский

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S100A4 makes two appearances in mechanisms leading to fibrosis

Journal of Biological Chemistry, Год журнала: 2024, Номер 300(6), С. 107385 - 107385

Опубликована: Май 15, 2024

Язык: Английский

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