A Multi‐Modal Approach for Exploring Sarcoma and Carcinoma Using FTIR and Polarimetric Analysis DOI Open Access

Muhammad Abubakar Siddique,

Munir Akhtar,

Muhammad Abdul Majid

и другие.

Microscopy Research and Technique, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

ABSTRACT Ex vivo characterization of sarcoma and carcinoma tissue samples was evaluated using microscopy, optical polarimetry, Fourier transform infrared (FTIR) spectroscopy, support vector machines (SVM). Recent evidence suggests that it is crucial to explore new diagnostic methods for detecting the smallest features cancer. In this paper, we discuss FTIR, which characterizes chemical composition tissues at different wavenumbers. The FTIR spectra exhibited significant differences in (OH, CH, NH) compared (NH, CO CH), particularly spectral range from 400 4000 cm −1 . Mueller matrix polarimetry (MMP) combined with polar decomposition used compare 13 polarimetric parameters ex across visible spectrum (400–800 nm), revealing significantly higher values all metrics samples. Microscopic analysis revealed distinctive morphological changes associated carcinoma, contributing these variations. All explored SVM demonstrated promise computer‐assisted classification two types. successfully achieved an overall 90% accuracy, sensitivity, specificity. These results suggest combination along SVM, holds potential automated pathology carcinoma.

Язык: Английский

Advanced delivery systems for oxygen therapeutics: center around red blood cells DOI
Wujie Zhang, Michael Navin

Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Март 9, 2025

Oxygen therapeutics hold great potential as alternatives to red blood cell/whole transfusions. The development of hemoglobin-based oxygen carriers began in the 1930s, but, regrettably, none have received FDA approval. This review starts with an overview cell physiology and then focuses on (including modified encapsulated hemoglobin) well mimetics, particularly regarding their size shape. also addresses different approaches carriers.

Язык: Английский

Процитировано

0
A Multi‐Modal Approach for Exploring Sarcoma and Carcinoma Using FTIR and Polarimetric Analysis DOI Open Access

Muhammad Abubakar Siddique,

Munir Akhtar,

Muhammad Abdul Majid

и другие.

Microscopy Research and Technique, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

ABSTRACT Ex vivo characterization of sarcoma and carcinoma tissue samples was evaluated using microscopy, optical polarimetry, Fourier transform infrared (FTIR) spectroscopy, support vector machines (SVM). Recent evidence suggests that it is crucial to explore new diagnostic methods for detecting the smallest features cancer. In this paper, we discuss FTIR, which characterizes chemical composition tissues at different wavenumbers. The FTIR spectra exhibited significant differences in (OH, CH, NH) compared (NH, CO CH), particularly spectral range from 400 4000 cm −1 . Mueller matrix polarimetry (MMP) combined with polar decomposition used compare 13 polarimetric parameters ex across visible spectrum (400–800 nm), revealing significantly higher values all metrics samples. Microscopic analysis revealed distinctive morphological changes associated carcinoma, contributing these variations. All explored SVM demonstrated promise computer‐assisted classification two types. successfully achieved an overall 90% accuracy, sensitivity, specificity. These results suggest combination along SVM, holds potential automated pathology carcinoma.

Язык: Английский

Процитировано

0