Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment

Regenerative Biomaterials, Год журнала: 2024, Номер 11

Опубликована: Янв. 1, 2024

Abstract The skin stratum corneum (SC) barrier function will interfere with the absorption of topical treatment and reduce drug's therapeutic effect on alopecia. Microneedles (MNs) can penetrate deliver drugs to dermis. Furthermore, MNs mechanically stimulate skin, which promotes hair growth. Thus, we designed a green dissolvable composite microneedle made hyaluronic acid (HA) Bletilla striata polysaccharide (BSP) encapsulate cholesterol-free ginsenoside Rg3 liposomes (Rg3-LPs) avoid cholesterol metabolism-producing testosterone inhibit regeneration minimize SC absorption. HA BSP enhance mechanical strength Rg3-MNs ensure transport follicle (HF) region while causing minimal irritation guaranteeing cell compatibility. In addition, increased density was more conducive regeneration. telogen effluvium (TE) testosterone-induced androgenetic alopecia (AGA) animals, achieved comparable efficacy minoxidil low-frequency quality regenerated higher. quantitative characterization transcriptome sequencing results showed that promoted by promoting expression Wnt3a Wnt10b genes, activating Wnt/β-catenin pathway. Therefore, present broad prospects in

Язык: Английский

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Multiple strategies approach: A novel crosslinked hydrogel forming chitosan-based microneedles chemowrap patch loaded with 5-fluorouracil liposomes for chronic wound cancer treatment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 134973 - 134973

Опубликована: Авг. 24, 2024

Язык: Английский

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Liposome-loaded dissolvable microneedle patches for more efficient intradermal antigen delivery of Hepatitis B vaccine

International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 125023 - 125023

Опубликована: Дек. 1, 2024

Язык: Английский

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Nano-Revolution in Transdermal Drug Delivery: A Bibliographic Compilation of Vesicular System

International Journal of Pharmaceutical Investigation, Год журнала: 2024, Номер 14(2), С. 317 - 326

Опубликована: Апрель 2, 2024

Background The growing popularity of transdermal patches is attributed to their advantageous characteristics, including the absence gastric-related problems, prolonged drug release, enhanced safety and stability, elimination need for punctures during systemic delivery. These features have prompted exploration novel techniques innovations in delivery systems optimize administration. Materials Methods To address aforementioned advantages, researchers focused on incorporating innovative approaches, with a particular emphasis utilization nano-vesicular systems. system has gained favour due its potential significantly increase accumulation at site administration, capacity easily incorporate wide range medications, ability minimize absorption. This study undertook an examination attempts made development implementation Results revealed successful adoption application results highlight efficacy this approach enhancing administration versatility accommodating various medications. Additionally, observed low absorption further underscores benefits Conclusion In conclusion, demonstrates increasing significance promising role played by addressing key challenges associated authors emphasizes advancements field encourages applications pharmaceutical

Язык: Английский

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A review of saponin-based nanocarriers for drug delivery

Next Nanotechnology, Год журнала: 2024, Номер 7, С. 100109 - 100109

Опубликована: Окт. 2, 2024

Язык: Английский

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