A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era DOI Open Access

Anca-Narcisa Neagu,

Taniya Jayaweera,

Krishan Weraduwage

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4981 - 4981

Опубликована: Май 2, 2024

We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating nanorobots, have demonstrated ingenious applications biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies real-time monitoring tumors, nanorobots designed perform multiple tasks at a small scale, even organelles molecular level. Over last few years, most been bioengineered as biomimetic biocompatible nano(bio)structures, resembling different organisms cells, such urchin, spider, octopus, fish, spermatozoon, flagellar bacterium helicoidal cyanobacterium. In this review, readers will be able deepen their knowledge structure, behavior role several types among other theranostics. summarized here characteristics many functionalized nanodevices counteract main neoplastic hallmark features BC, from sustaining proliferation evading anti-growth signaling resisting programmed cell death inducing angiogenesis, activating invasion metastasis, preventing genomic instability, avoiding immune destruction deregulating autophagy. Most these function targeted self-propelled smart nano-carriers nano-drug delivery systems (nano-DDSs), enhancing efficiency safety chemo-, radio- photodynamic therapy, current imagistic techniques used diagnosis. tested vitro, using various lines, well vivo, mainly based on mice models. still waiting for that low-cost, wider transition favorable effects laboratory clinical practice.

Язык: Английский

Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. DOI Creative Commons
Ana Paula Abreu, Rodrigo Martins, João Nunes

и другие.

Bioengineering, Год журнала: 2023, Номер 10(8), С. 955 - 955

Опубликована: Авг. 11, 2023

Chlorella sp. and Spirulina (Arthrospira) account for over 90% of the global microalgal biomass production represent one most promising aquiculture bioeconomy systems. These microorganisms have been widely recognized their nutritional therapeutic properties; therefore, a significant growth market is expected, especially in nutraceutical, food, beverage segments. However, recent advancements biotechnology environmental science led to emergence new applications these microorganisms. This paper aims explore innovative applications, while shedding light on roles sustainable development, health, industry. From this state-of-the art review, it was possible give an in-depth outlook sustainability For instance, there variety studies reported use two wastewater treatment biofuel production, contributing climate change mitigation efforts. Moreover, health sector, richness microalgae photosynthetic pigments bioactive compounds, along with oxygen-releasing capacity, are being harnessed development drugs, wound-healing dressings, photosensitizers photodynamic therapy, tissue engineering, anticancer treatments. Furthermore, industrial used biopolymers, fuel cells, photovoltaic technologies. might bring different outlets valorization, enhancing potential, since sector presents issues such as high costs. Thus, further research highly needed fully benefits potential various sectors.

Язык: Английский

Процитировано

49
A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery DOI Creative Commons
Fariba Mehvari, Vahid Ramezanzade, Parvin Asadi

и другие.

Aggregate, Год журнала: 2024, Номер 5(2)

Опубликована: Янв. 4, 2024

Abstract The development of efficient drug delivery systems is essential for improving the efficacy and safety cancer drugs, particularly aggressive difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in (DDS), due to their unique properties, including metal‐free skeleton, predetermined structures pore geometries, high porosity, large surface area, facile modification potential, good biocompatibility. These characteristics make COFs excellent candidates by enhancing loading capacity enabling precise encapsulation. This review emphasizes importance donor‐acceptor‐based COFs, which provide channels charge transportation, we also explore how π‐conjugated skeleton enhances its long‐acting fluorescent properties facilitates uptake via cell endocytosis. While this primarily focuses on recent advancements COF‐based targeted DDS, it acknowledges challenges posed diverse geometries materials discusses potential solutions. Further, underlines developing future carriers that can successfully specifically target cells, treatment efficiency while reducing adverse side effects.

Язык: Английский

Процитировано

16
Recent Advances in Electrospinning Techniques for Precise Medicine DOI Creative Commons
Wei Li, Yue Yin, Huaijuan Zhou

и другие.

Cyborg and Bionic Systems, Год журнала: 2024, Номер 5

Опубликована: Янв. 1, 2024

In the realm of precise medicine, advancement manufacturing technologies is vital for enhancing capabilities medical devices such as nano/microrobots, wearable/implantable biosensors, and organ-on-chip systems, which serve to accurately acquire analyze patients’ physiopathological information perform patient-specific therapy. Electrospinning holds great promise in engineering materials components advanced devices, due demonstrated ability advance development nanomaterial science. Nevertheless, challenges limited composition variety, uncontrollable fiber orientation, difficulties incorporating fragile molecules cells, low production effectiveness hindered its further application. To overcome these challenges, electrospinning techniques have been explored manufacture functional composites, orchestrated structures, living constructs, scale-up fabrication. This review delves into recent advances underscores their potential revolutionizing field upon introducing fundamental conventional techniques, well discussing current future perspectives.

Язык: Английский

Процитировано

13
Medical Defense Nanorobots (MDNRs): a new evaluation and selection of controller criteria for improved disease diagnosis and patient safety using NARMA(L2)-FOP + D(ANFIS)µ – Iλ-based Archimedes Optimization Algorithm DOI
Hamzah M. Marhoon, Noorulden Basil,

Abdullah Fadhil Mohammed

и другие.

International Journal of Information Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 20, 2024

Язык: Английский

Процитировано

9
Active Microrobots for Dual Removal of Biofilms via Chemical and Physical Mechanisms DOI Creative Commons
Peng Xia, Çağatay M. Oral,

Mario Urso

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(2), С. 3608 - 3619

Опубликована: Янв. 2, 2025

Bacterial biofilms are complex multicellular communities that adhere firmly to solid surfaces. They widely recognized as major threats human health, contributing issues such persistent infections on medical implants and severe contamination in drinking water systems. As a potential treatment for biofilms, this work proposes two strategies: (i) light-driven ZnFe2O4 (ZFO)/Pt microrobots photodegradation of (ii) magnetically driven ZFO mechanical removal from Magnetically were realized by synthesizing microspheres through low-cost large-scale hydrothermal synthesis, followed calcination process. Then, Pt layer was deposited the surface break their symmetry, resulting self-propelled Janus ZFO/Pt microrobots. Light-driven exhibited active locomotion under UV light irradiation controllable motion terms "stop go" features. capable maneuvering precisely when subjected an external rotating magnetic field. These could eliminate Gram-negative Escherichia coli (E. coli) photogenerated reactive oxygen species (ROS)-related antibacterial properties combination with light-powered locomotion, accelerating mass transfer remove more effectively water. Moreover, actuation allowed physical disruption which represents reliable alternative photocatalysis strongly anchored confined spaces. With versatile characteristics, envisioned highlight significant biofilm high efficacy both open spaces, pipelines industrial plants.

Язык: Английский

Процитировано

1
Application of photosensitive microalgae in targeted tumor therapy DOI
Ruoxi Wang,

Zhouyue Wang,

Min Zhang

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер unknown, С. 115519 - 115519

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Metareview: a survey of active matter reviews DOI Creative Commons
Michael te Vrugt, Raphael Wittkowski

The European Physical Journal E, Год журнала: 2025, Номер 48(2)

Опубликована: Фев. 1, 2025

In the past years, amount of research on active matter has grown extremely rapidly, a fact that is reflected in particular by existence more than 1000 reviews this topic. Moreover, field become very diverse, ranging from theoretical studies statistical mechanics particles to applied work medical applications microrobots and biological systems artificial swimmers. This makes it difficult get an overview over as whole. Here, we provide such form metareview article surveys existing review articles books matter. Thereby, provides useful starting point for finding literature about specific

Язык: Английский

Процитировано

1
Continuum Robots and Magnetic Soft Robots: From Models to Interdisciplinary Challenges for Medical Applications DOI Creative Commons
Honghong Wang, Yi Mao, Jingli Du

и другие.

Micromachines, Год журнала: 2024, Номер 15(3), С. 313 - 313

Опубликована: Фев. 24, 2024

This article explores the challenges of continuum and magnetic soft robotics for medical applications, extending from model development to an interdisciplinary perspective. First, we established a unified framework based on algebra geometry. The research progress in principle models, data-driven, hybrid modeling were then analyzed depth. Simultaneously, numerical analysis was constructed. Furthermore, expanded encompass conducted comprehensive analysis, including in-depth case study. Current need address meta-problems identified through discussion. Overall, this review provides novel perspective understanding complexities paving way researchers assimilate knowledge domain rapidly.

Язык: Английский

Процитировано

7
Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery DOI
Shishuai Qiao,

Hangkong Ouyang,

Xiaoguang Zheng

и другие.

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(26), С. 6095 - 6105

Опубликована: Янв. 1, 2023

A triaxial microfluidic chip and a magnetic drive system developed in this paper greatly reduce the complexity cost of system. The prepared capsule microrobots have excellent potential for drug delivery similar vascular microchannels.

Язык: Английский

Процитировано

15
Micro robot as the feature of robotic in healthcare approach from design to application: the State of art and challenges DOI Creative Commons
Ata Jahangir Moshayedi, Amir Sohail Khan,

Mehdi Davari

и другие.

EAI Endorsed Transactions on AI and Robotics, Год журнала: 2024, Номер 3

Опубликована: Апрель 12, 2024

Micro robots, miniature robotic devices typically ranging from micrometers to a few millimeters in size, hold immense potential various fields, particularly healthcare. Their diminutive stature enables access intricate anatomical regions previously unreachable, facilitating targeted drug delivery, localized treatment, and precise monitoring. These robots offer numerous advantages, including enhanced maneuverability, reduced invasiveness, minimized tissue damage. By navigating through complex biological environments, micro can deliver therapies with unprecedented precision, improving treatment efficacy patient outcomes. Additionally, their small size allows for minimally invasive procedures, reducing recovery times enhancing comfort. Overall, represent groundbreaking technological advancement the revolutionize healthcare delivery significantly benefit human well-being.Their Despite challenges like constraints navigation complexities, innovative solutions interdisciplinary collaboration are driving

Язык: Английский

Процитировано

5