Biomaterials for extrusion-based bioprinting and biomedical applications

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Июнь 21, 2024

Amongst the range of bioprinting technologies currently available, by material extrusion is gaining increasing popularity due to accessibility, low cost, and absence energy sources, such as lasers, which may significantly damage cells. New applications extrusion-based are systematically emerging in biomedical field relation tissue organ fabrication. Extrusion-based presents a series specific challenges achievable resolutions, accuracy speed. Resolution particular paramount importance for realization microstructures (for example, vascularization) within tissues organs. Another major theme research cell survival functional preservation, extruded bioinks have cells subjected considerable shear stresses they travel through apparatus. Here, an overview main available printing related families materials (bioinks) provided. The achieving resolution whilst assuring viability function discussed application contexts

Язык: Английский

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An additive manufacturing approach for fabrication of agarose hydrogel structures for protein sorption application

Materials & Design, Год журнала: 2025, Номер unknown, С. 113581 - 113581

Опубликована: Янв. 1, 2025

Язык: Английский

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A review of biomacromolecule-based 3D bioprinting strategies for structure-function integrated repair of skin tissues

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131623 - 131623

Опубликована: Апрель 19, 2024

Язык: Английский

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Three-Dimensional Printing/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 28 - 28

Опубликована: Янв. 16, 2025

The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field regenerative medicine. This paper aims provide a comprehensive overview 3D technology therapies, highlighting results diverse medical applications, while also discussing capabilities limitations combined use. synergistic combination printing cellular been recognised as promising innovative approach, it is expected that these will progressively assume crucial role treatment various diseases conditions foreseeable future. review concludes with forward-looking perspective on future impact technologies, revolutionize medicine through enhanced tissue repair organ replacement strategies.

Язык: Английский

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A review of polysaccharide-based hydrogels: from structural modification to biomedical applications

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143519 - 143519

Опубликована: Апрель 25, 2025

Язык: Английский

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Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices

Materials & Design, Год журнала: 2024, Номер 237, С. 112616 - 112616

Опубликована: Янв. 1, 2024

Additive manufacturing (AM) is a versatile technology with potential applications in healthcare and medical instruments, where surface disinfection or sterilization essential. This study comprehensively the effect of commonly used cost-effective disinfectants, ethanol (70 V/V%) chlorine solution on mechanical thermal properties flexible 3D printed materials. The following materials were tested before after 5-cycle disinfection: Flexfill TPE 90A, Phyton Flex (TPU) for material extrusion, Flexible (resin), Elastic 50A (resin) vat photopolymerization Flexa Black powder bed fusion technology. Mechanical tests included tensile, compression, Charpy impact, flex resistance stress relaxation tests, as well Shore A hardness volume measurements. structure was analyzed using scanning electron microscopy (SEM)and Raman spectroscopy. cytotoxicity assessed A549 cell viability assay. results show that disinfection, significant changes occurred mainly tensile properties, such strength disinfected 3.44 MPa ± 0.51 (ethanol) 2.62 0.31 compared to native 2.02 0.24 MPa. Interestingly, applied disinfectants can negatively affect biocompatibility. Medical devices have been designed fabricated based findings. Our findings serve guide biomedical field.

Язык: Английский

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Tissue‐engineered vascular grafts for cardiovascular disease management: Current strategies, challenges, and future perspectives

MedComm – Biomaterials and Applications, Год журнала: 2024, Номер 3(3)

Опубликована: Июль 9, 2024

Abstract Cardiovascular diseases are the leading cause of mortality which primarily occurs due to blood vessel obstruction or narrowing. Surgical procedures such as, coronary artery and peripheral bypass grafting frequently require vascular grafts for long‐term revascularization. However, using autogenous vessels, as internal thoracic saphenous vein, especially vessels with diameters less than 6 mm, associated number concerns limited availability, invasive retrieval procedures, aptness. To overcome these limitations, development tissue‐engineered (TEVGs) is in continuous thrust. This review comprehensively provides potentiality a range artificial naturally occurring biopolymers their fabrication techniques, cell sources seeding techniques realize state‐of‐the‐art TEVGs. Moreover, this article presents synopsis insights obtained from variety vitro vivo studies, including human clinical trials. It underscores need further exploration into key areas optimal sources, mechanical properties, hemodynamics, graft integration, impact patient conditions, optimum burst pressure, sufficient suture strength, hydrophilicity, biodegradability, related factors. In summary, offers current strategies, challenges, future perspectives TEVG.

Язык: Английский

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Recent advances in 3D bioprinting of tissues and organs for transplantation and drug screening

Virtual and Physical Prototyping, Год журнала: 2024, Номер 19(1)

Опубликована: Авг. 5, 2024

Organ transplantation is the optimal treatment for patients with end-stage organ failure, but which faces challenge of donor shortage. Two-dimensional cell culture and animal experiments are difficult to completely simulate complex cellular microenvironment drug testing. Three-dimensional (3D) bioprinting an emerging manufacturing technology fabricate artificial tissues organs screening. This review first describes technologies used constructs, including jetting-based, extrusion-based, vat photopolymerization-based methods other 3D approaches. The various kinds bioinks, sources, most recent applications in testing subsequently summarized. Finally, we discuss challenges prospects organs. aims facilitate overcoming obstacles identified on challenging journey towards adoption tissue

Язык: Английский

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Advancement in Cancer Vasculogenesis Modeling through 3D Bioprinting Technology

Biomimetics, Год журнала: 2024, Номер 9(5), С. 306 - 306

Опубликована: Май 20, 2024

Cancer vasculogenesis is a pivotal focus of cancer research and treatment given its critical role in tumor development, metastasis, the formation vasculogenic microenvironments. Traditional approaches to investigating face significant challenges accurately modeling intricate Recent advancements three-dimensional (3D) bioprinting technology present promising solutions these challenges. This review provides an overview underscores importance precise modeling. It juxtaposes traditional techniques with 3D technologies, elucidating advantages latter developing models. Furthermore, it explores applications pathological investigations, preclinical medication screening for personalized diagnostics, envisages future prospects bioprinted Despite notable advancements, current have several limitations. Nonetheless, by overcoming technological advances, exhibits immense potential revolutionizing understanding augmenting modalities.

Язык: Английский

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Advances and Challenges in 3D Bioprinted Cancer Models: Opportunities for Personalized Medicine and Tissue Engineering

Polymers, Год журнала: 2025, Номер 17(7), С. 948 - 948

Опубликована: Март 31, 2025

Cancer is the second leading cause of death worldwide, after cardiovascular disease, claiming not only a staggering number lives but also causing considerable health and economic devastation, particularly in less-developed countries. Therapeutic interventions are impeded by differences patient-to-patient responses to anti-cancer drugs. A personalized medicine approach crucial for treating specific patient groups includes using molecular genetic screens find appropriate stratifications patients who will respond (and those not) treatment regimens. However, information on which risk stratification method can be used hone cancer types likely responders agent remains elusive most cancers. Novel developments 3D bioprinting technology have been widely applied recreate relevant bioengineered tumor organotypic structures capable mimicking human tissue microenvironment or adequate drug high-throughput screening settings. Parts autogenously printed form tissues computer-aided design concept where multiple layers include different cell compatible biomaterials build configurations. Patient-derived stromal cells, together with material, extracellular matrix proteins, growth factors, create bioprinted models that provide possible platform new therapies advance. Both natural synthetic biopolymers encourage cells biological materials models/implants. These may facilitate physiologically cell-cell cell-matrix interactions heterogeneity resembling real tumors.

Язык: Английский

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