Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 26, 2025

Язык: Английский

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Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Авг. 2, 2023

Introduction: Hydroxyapatite (HAP or HA) nanofibers are very attractive in the field of biomedical engineering. However, templates used for preparing HAP usually hydrophobic molecules, like fatty acids and/or surfactants, which difficult to remove and potentially toxic. Therefore, it is important develop a green approach prepare nanofibers. Methods: Imidazolium-based ionic liquids (ILs) were as control crystallization HAP. The obtained composited into polyvinyl alcohol-sodium alginate (PVA-Alg) hydrogel (HAP@H). rheological performance, stretching, compression properties tested. Scanning electron microscope (SEM), high resolution transmission (HRTEM), X-ray diffraction (XRD), Fourier-transform infrared (FT-IR), differential scanning calorimetry (DSC) adopted characterize morphology, size, crystallographic orientations, phase HAP@H. Results: with length ∼50 μm harvested. DSC results proved that water loss temperature increased from 98°C (for pure hydrogel) 107°C HAP@H). Also, HAP@H presented much better porous structure, tensile compressive performance than hydrogel. Discussion: growth direction could be modulated easily by altering alkyl chain ILs' cations. This possibly due face-specific adsorption imidazolium moieties on nanocrystals. enhancing probably highly oriented

Язык: Английский

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Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(7), С. 4195 - 4226

Опубликована: Май 16, 2024

Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, have become one of the most serious persistent complications diabetes mellitus because their high incidence difficulty in healing. Its malignancy results from a complex microenvironment that includes series unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, inflammation, ischemia hypoxia. However, current common clinical treatments, antibiotic therapy, insulin surgical debridement, conventional wound dressings all drawbacks, suboptimal outcomes exacerbate financial physical burdens patients. Therefore, development new, effective affordable treatments for DFU represents top priority improve quality life In recent years, nanozymes-based therapy systems been attracting extensive interest integrating unique advantages nanomaterials natural enzymes. Compared with enzymes, nanozymes possess more stable catalytic activity, lower production cost greater maneuverability. Remarkably, many multienzyme activities can cascade multiple enzyme-catalyzed reactions simultaneously throughout recovery process DFU. Additionally, favorable photothermal-acoustic properties be exploited further enhancement therapeutic effects. this review we first describe characteristic pathological DFU, then discuss mechanisms applications healing, finally, highlight challenges perspectives nanozyme treatment.

Язык: Английский

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Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots

Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 671 - 671

Опубликована: Май 16, 2024

The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates mechanisms synergistic healing potential NIR and silver metal–organic frameworks combined with nitrogen- sulfur-doped carbon dots (AgMOFsN-CDs AgMOFsS-CDs, respectively), which was conducted by testing fibroblasts viability, scratch assays, biochemical analysis, synchrotron-based Fourier transform infrared (SR-FTIR) cell spectroscopy imaging. Our findings reveal treatment AgMOFsN-CDs significantly increases viability to nearly 150% promotes proliferation, reduced interleukin-1 levels, suggesting an anti-inflammatory response. SR-FTIR shows this results in unique protein alterations, including increased α-helix structures cross-β. Additionally, synthesis enhanced upon treatment. likely mechanism behind observed changes is charge-specific interaction N-CDs from proteins, due nanocomposite’s optical characteristics. Remarkably, complete closure vitro assay achieved exclusively treatment, demonstrating promising application photodynamic therapy regenerative nanomedicine tissue engineering.

Язык: Английский

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Classification of nanozymes

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 19 - 44

Опубликована: Янв. 1, 2024

Язык: Английский

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